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Paper-scoped peptide mentionSequence reported

P9

PMC10126514::PEP000001

Source publication

The interaction of peptide inhibitors and Aβ protein: Binding mode analysis, inhibition of the formation of Aβ aggregates, and then exert neuroprotective effects.

Frontiers in Aging Neuroscience · 2023

DOI 10.3389/fnagi.2023.1139418PMC10126514PMID 37113572
Sequence status
reported
Standardization
Sequence ready
Source location
text
Activity records
3

Sequence evidence

Reported molecular identity

YVRHHHYVRHHH

P9(Ac-YVRHHHYVRHHH-NH2) was purchased from GL Biochem Ltd. (Shanghai).

Resolved peptide links

PEPDIA-PLP-003360

Experimental observations

Records linked to this mention

ToxicityCytotoxicNegative / threshold
Record detail

Figure 3A: cell viability of P9 at a lower concentration (6.25 uM) began to decrease significantly (p < 0.05), and the cell viability of 25, 50, 100, and 200 uM also decreased significantly, with extremely significant differences (p < 0.01).

Mention PMC10126514::PEP000001PMC10126514text
Measure
cell_viability
Value
cell viability decreased significantly at 6.25 uM (p<0.05), and at 25, 50, 100, 200 uM (p<0.01)
Target
Rattus norvegicus
Assay
Not reported by source
Source publication
OtherAnti-AggregationPositive observation
Record detail

Figure 4: compared with the Aβ positive control group, the fluorescence intensity of P9 and P12 polypeptides has increased, but the difference is not statistically significant (p > 0.05), indicating that P9 and P12 have no inhibitory effect on Aβ aggregation.

Mention PMC10126514::PEP000001PMC10126514text
Measure
percent_inhibition
Value
fluorescence intensity increased, no inhibitory effect (p>0.05)
Target
Aβ1-42
Assay
Not reported by source
Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.