ProForma 2.0
validated simple linear
YVRHHHYVRHHH
Back to Primary literature
Primary-literature peptidemedium evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003360
P9
Aliases: P9
Normalized sequence
YVRHHHYVRHHH
12 amino acids
Release PepDiana-V1-20260620
3
Activity records
1
Source papers
2
Positive
1
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
1677.8309 Da
Molecular formula
C76H104N30O15
Theoretical pI
9.9866
Net charge at pH 7
2.2811
GRAVY
-1.8667
Instability index
77.8833
Aromaticity
0.1667
Topological polar surface area
719.76 Ų
cLogP
-4.739
Hydrogen-bond donors
27
Hydrogen-bond acceptors
23
Rotatable bonds
49
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{Y.V.R.H.H.H.Y.V.R.H.H.H}$$$$V2.0
Canonical SMILES
validated
CC(C)C(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1c[nH]cn1)C(=O)O)C(C)C
Isomeric SMILES
validated
CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Other 2 records
PMC10126514
2 observationsOtherAnti-AggregationPositive observation
Record detail Figure 4: compared with the Aβ positive control group, the fluorescence intensity of P9 and P12 polypeptides has increased, but the difference is not statistically significant (p > 0.05), indicating that P9 and P12 have no inhibitory effect on Aβ aggregation.
- Measure
- percent_inhibition
- Value
- fluorescence intensity increased, no inhibitory effect (p>0.05)
- Target
- Aβ1-42
- Assay
- Not reported by source
OtherBinding AffinityPositive observation
Record detail Table 3: KD (M) for P9 is 1.401 × 10−5.
- Measure
- Kd
- Value
- 1.401 × 10−5 M
- Target
- Aβ1-42
- Assay
- Not reported by source
Toxicity 1 records
PMC10126514
1 observationsToxicityCytotoxicNegative / threshold
Record detail Figure 3A: cell viability of P9 at a lower concentration (6.25 uM) began to decrease significantly (p < 0.05), and the cell viability of 25, 50, 100, and 200 uM also decreased significantly, with extremely significant differences (p < 0.01).
- Measure
- cell_viability
- Value
- cell viability decreased significantly at 6.25 uM (p<0.05), and at 25, 50, 100, 200 uM (p<0.01)
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003360, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00