Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_1139 | A04T.2 | Molecule | Ochratoxin B | 71 μM | 20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl | 30085205 |
Structure information of aptamer
| Aptamer Sequence: | AATAGGGTAAAAAAAAAAAGTTGGTCCTATG |
| The optimal secondary structure in dot-bracket notation: | .((((((.................)))))). |
| The centroid secondary structure in dot-bracket notation: | .((((((.................)))))). |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_1139 | Description | A04T.2 |
| Aptamer chemistry | DNA | Length | 31 nt |
| GC content | 29.0% | Molecular weight | 9,648.29 Da |
| Molarity of 1 μg/μl solution | 103.65 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted binding |
| Sequence | AATAGGGTAAAAAAAAAAAGTTGGTCCTATG | ||
| Applications | Binding to targets | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 20966 | Molecular name | Ochratoxin B |
| Molecular formula | C20H19NO6 | Molecular weight | 369.4 |
| IUPAC name | (2S)-2-[[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromene-7-carbonyl]amino]-3-phenylpropanoic acid | InChIKey | DAEYIVCTQUFNTM-ABAIWWIYSA-N |
| LogP | 1.919 | Topological polar surface area | 112.93 |
| Hydrogen bond acceptor | 5 | Hydrogen bond donor | 3 |
Synonym(s): OCHRATOXIN B; 4825-86-9; UNII-ECJ5WS94N2; ECJ5WS94N2; L-Phenylalanine,N-[[(3R)-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-; Alanine, N-((8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl-, (-)-; L-Phenylalanine, N-((3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)-, (R)-; Alanine, N-[(8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-; L-Phenylalanine, N-[(3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-, (R)-; CCRIS 5094; HSDB 3438; BRN 1300160; Ochratoxin B(OTB); SCHEMBL455061; DTXSID1075301; CHEBI:141524; N-[(8-Hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromen-7-yl)carbonyl]phenylalanine #; ZINC5260598; AKOS030242138; 2-[((3R)-8-HYDROXY-3-METHYL-1-OXOISOCHROMAN-7-YL)CARBONYLAMINO](2S)-3-PHENYLPR OPANOIC ACID; Q3880769; Ochratoxin B solution, 10 mug/mL in acetonitrile, analytical standard; (S)-2-((R)-8-hydroxy-3-methyl-1-oxoisochroman-7-carboxamido)-3-phenylpropanoic acid; N-[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carbonyl]-L-phenylalanine; (2S)-2-{[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carbonyl]amino}-3-phenylpropanoic acid; L-Phenylalanine, N-(((3R)-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)-; N-{[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromen-7-yl]carbonyl}-L-phenylalanine; OTB
Activity data
 |
Interaction ID | 1195 |
| Target type | Molecule | |
| Target unique ID | 442530 | |
| Activity | 71 nM | |
| Binding Conditions/Buffer | 20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl |
|
| Assay | Binding isotherms for aptamer |
|
| PubMed ID | 30085205 | |
 |
Interaction ID | 1196 |
| Target type | Molecule | |
| Target unique ID | 20966 | |
| Activity | 71 μM | |
| Binding Conditions/Buffer | 20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl |
|
| Assay | Binding isotherms for aptamer |
|
| PubMed ID | 30085205 | |
 |
Interaction ID | 1197 |
| Target type | Molecule | |
| Target unique ID | 54678486 | |
| Activity | 1492 nM | |
| Binding Conditions/Buffer | 20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl |
|
| Assay | Binding isotherms for aptamer |
|
| PubMed ID | 30085205 | |
 |
Interaction ID | 1198 |
| Target type | Molecule | |
| Target unique ID | 54680783 | |
| Activity | 3918 nM | |
| Binding Conditions/Buffer | 20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl |
|
| Assay | Binding isotherms for aptamer |
|
| PubMed ID | 30085205 | |
 |
Interaction ID | 1199 |
| Target type | Molecule | |
| Target unique ID | 186907 | |
| Activity | 33 μM | |
| Binding Conditions/Buffer | 20 mM Tris-HCl, 10 mM (NH4)2SO4, 10 mM KCl |
|
| Assay | Binding isotherms for aptamer |
|
| PubMed ID | 30085205 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_419 | DNA | ATCAGGGCTAAAGAGTGCAGAGTTACTTAG | |
| Apta_1152 | DNA | GACAAGGATAAATCCTTCAATGAAGTGGGTCACTCATCTGTGA | |
| Apta_929 | DNA | GAGTGGGATGGATAGAGAATAAGTGTGGAGTGGAAGGTGA | |
| Apta_343 | DNA | AACAGAGGGACAAACGGGGGAAGATTTGACGTCGACGAC | |
| Apta_847 | DNA | CACTAGGATCTAGGGAAAAATCTCGTAAATACTATACTCCTGAGC | |
| Apta_261 | DNA | TAAACCCCAAAACAGTGCAACTAGGTGTAGGTCCCGTGGT | |
| Apta_512 | DNA | ATAGGACGATTATCGAAAATCACCAGATTGGACCCTGGTTAACGAT | |
| Apta_580 | DNA | ATGCGGGTATATGGTGCGAGAAAACAAGGGGCATACTGGA | |
| Apta_783 | DNA | AAGGGGTTGGGTGGGTTTATACAAATTAATTAATATTGTATGGTATATTT | |
| Apta_876 | DNA | GTTGCGAAAGACAACGAATGCTTTGCCTGCCATAATTTGC | |
| Apta_946 | DNA | TACCGGGTAATATGCACACATGCTGATAGCAAGCAATGCA | |
| Apta_977 | DNA | CAATCTGCTAAAACTTAAAGCCTATTAATGAAATTGTTAAGGTGGTATCC | |
| Apta_1286 | DNA | CTATACGTATTCTAACTTGTTACGTATTGGTCTCTTATTG | |
| Apta_639 | DNA | CTAAGCACAGGGAAACCAGCTAATGAGTTAGGCCTGTCCCCCACG | |
| Apta_640 | DNA | CAATGGACCTATTCGAGTACTGAATAGAACAGTCGGCGCTCTGGG | |
| Apta_158 | DNA | CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTG | |
| Apta_347 | DNA | AAAAAAAAAAAAGTACGTTCAGGAGCAGTGCGA | |
| Apta_213 | DNA | AGGAAGGCAAAAGGAAAAAAAAAAAGGAAA | |
| Apta_330 | DNA | GCTGGGTAAATAGATGATTCCCGGC | |
| Apta_514 | DNA | ACTCAGCACGCGTGTAGGGAAAACCAACCGCCCACAAGCTGCATGCAACG |
DEV TOOL
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