Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_758 | E3 | Cell | Prostate cancer cells | 146 nM | DPBS with Ca2+ and Mg2+ | 29666232 |
Structure information of aptamer
| Aptamer Sequence: | GGCUUUCGGGCUUUCGGCAACAUCAGCCCCUCAGCC |
| The optimal secondary structure in dot-bracket notation: | ((((...(((((............)))))...)))) |
| The centroid secondary structure in dot-bracket notation: | ((((...(((((............)))))...)))) |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_758 | Description | E3 |
| Aptamer chemistry | RNA | Length | 36 nt |
| GC content | 63.9% | Molecular weight | 11,412.78 Da |
| Molarity of 1 μg/μl solution | 87.62 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted therapy |
| Sequence | GGCUUUCGGGCUUUCGGCAACAUCAGCCCCUCAGCC | ||
| Applications | Efficiently kills prostate cancer cells in vitro but does not affect normal prostate epithelial cells | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| ATCC ID | HTB-81 | Cell name | Prostate cancer cells |
| Category | Human cells | Organism | Homo sapiens, human |
| Product type | N/A | Cell type | N/A |
| Morphology | epithelial | Tissue | Prostate |
| Disease | Carcinoma | Product format | Frozen |
| Antigen expression | Blood Type O; Rh+ | Genes expressed | N/A |
| Cell description | DU 145 is a cell line with epithelial morphology that was isolated from the brain of a 69-year-old, White, male with prostate cancer. This cell line is suitable as a transfection host. |
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|
| Application(s) | 3D cell culture; Cancer research; Neuroscience | ||
Activity data
 |
Interaction ID | 841 |
| Target type | Cell | |
| Target unique ID | HTB-81 | |
| Activity | 146 nM | |
| Binding Conditions/Buffer | DPBS with Ca2+ and Mg2+ |
|
| Assay | E3 targets prostate cancer cells with nanomolar apparent affinity |
|
| PubMed ID | 29666232 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_1288 | RNA | GGCGCACUGGCGCUGCGCCUUCGGGCGCCAAUCGUAGCGUGUCGGCGCC | |
| Apta_634 | RNA | GGUCUUACGUCGUUCGCGACUAUUGGGAGACC | |
| Apta_366 | RNA | GGUUAGAGGCGACGUCCCGGAAUCCGCGCCCAUUGCCCCC | |
| Apta_521 | RNA | GGGUUGGGAAGAAACUGUGGCACUUCGGUGCCAGCAACCC | |
| Apta_271 | RNA | CUGUCGAGCAUGCUCAGGGUAACGUAUAGUCAAGACACCUCAAGUGUAACU | |
| Apta_424 | RNA | UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG | |
| Apta_426 | RNA | UGCCGCUAUAAUGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG | |
| Apta_1143 | RNA | ACGAGUUGUCGCAUGUGCGGUUCAGUCUGGUCCUUCAGCACCGUACAACAA | |
| Apta_856 | RNA | UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA | |
| Apta_270 | RNA | CUGUCGAACAUGCUGAGGGUAACGUACUGGCAAGCUCACCUCAGCGUAGCUAa | |
| Apta_132 | RNA | GGGAGGACGAUGCGGCGUUUCCUCUGGUUCGUCCCCAGACGACUCGCCCGA | |
| Apta_134 | RNA | GGGAGGACGAUGCGGGCCGUUGUUGUGUGCCGCCCCAGACGACUCGCCCGA | |
| Apta_135 | RNA | GGGAGGACGAUGCGGAUUCUGGUUACUGGCCGCCCCAGACGACUCGCCCGA | |
| Apta_315 | RNA | GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA | |
| Apta_425 | RNA | UGCCGCCAUAUCACACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG | |
| Apta_859 | RNA | GGGAGUCUGAAGUCGGACUUGUUAUCAAUUCACUUCAGACU | |
| Apta_51 | RNA | GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC | |
| Apta_599 | RNA | GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC | |
| Apta_599 | RNA | GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC | |
| Apta_269 | RNA | AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC |
DEV TOOL
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