Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 424
Aptamer sequence: TGGCAGGAAGACAAACACATCGTCGCGGCCTTAGGAGGGGCGGACGGGGGGGGGCGTGGTCTGTGGTGCTGT
Target unique ID: P69905
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_418 | Glycated Hemoglobin Aptamer | Protein | HBA_HUMAN | 7.3 nM | 10 mM Tris, 100mM NaCl, 2mM CaCl2, 1% BSA | 26797251 |
Structure information of aptamer
| Aptamer Sequence: | TGGCAGGAAGACAAACACATCGTCGCGGCCTTAGGAGGGGCGGACGGGGGGGGGCGTGGTCTGTGGTGCTGT |
| The optimal secondary structure in dot-bracket notation: | .((((...((((..((...((.((.(((((((....)))))...)).)).))...)).))))....)))).. |
| The centroid secondary structure in dot-bracket notation: | .((((...((((........((((.((.............))))))............))))....)))).. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_418 | Description | Glycated Hemoglobin Aptamer |
| Aptamer chemistry | DNA | Length | 72 nt |
| GC content | 66.7% | Molecular weight | 22,588.38 Da |
| Molarity of 1 μg/μl solution | 44.27 μM | Number of G-quadruplexes | 2 |
| G-Score | 21 | Function | Aptasensor |
| Sequence | TGGCAGGAAGACAAACACATCGTCGCGGCCTTAGGAGGGGCGGACGGGGGGGGGCGTGGTCTGTGGTGCTGT | ||
| Applications | The detection process of human whole blood | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | P69905 | Protein name | Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin] |
| Gene name(s) | HBA1; HBA2 | Organism | Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin] |
| Status | reviewed in uniprot database | Length | 142 |
| Mass | 15,258 | Activity regulation | N/A |
| Involvement in disease | Heinz body anemias (HEIBAN) | Catalytic activity | N/A |
| PDB ID(s) | 1A00;1A01;1A0U;1A0Z;1A3N;1A3O;1A9W;1ABW;1ABY;1AJ9;1B86;1BAB;1BBB;1BIJ;1BUW;1BZ0;1BZ1;1BZZ;1C7B;1C7C;1C7D;1CLS;1CMY;1COH;1DKE;1DXT;1DXU;1DXV;1FDH;1FN3;1G9V;1GBU;1GBV;1GLI;1GZX;1HAB;1HAC;1HBA;1HBB;1HBS;1HCO;1HDB;1HGA;1HGB;1HGC;1HHO;1IRD;1J3Y;1J3Z;1J40;1J41;1J7S;1J7W;1J7Y;1JY7;1K0Y;1K1K;1KD2;1LFL;1LFQ;1LFT;1LFV;1LFY;1LFZ;1LJW;1M9P;1MKO;1NEJ;1NIH;1NQP;1O1I;1O1J;1O1K;1O1L;1O1M;1O1N;1O1O;1O1P;1QI8;1QSH;1QSI;1QXD;1QXE;1R1X;1R1Y;1RPS;1RQ3;1RQ4;1RQA;1RVW;1SDK;1SDL;1SHR;1SI4;1THB;1UIW;1VWT;1XXT;1XY0;1XYE;1XZ2;1XZ4;1XZ5;1XZ7;1XZU;1XZV;1Y01;1Y09;1Y0A;1Y0C;1Y0D;1Y0T;1Y0W;1Y22;1Y2Z;1Y31;1Y35;1Y45;1Y46;1Y4B;1Y4F;1Y4G;1Y4P;1Y4Q;1Y4R;1Y4V;1Y5F;1Y5J;1Y5K;1Y7C;1Y7D;1Y7G;1Y7Z;1Y83;1Y85;1Y8W;1YDZ;1YE0;1YE1;1YE2;1YEN;1YEO;1YEQ;1YEU;1YEV;1YFF;1YG5;1YGD;1YGF;1YH9;1YHE;1YHR;1YIE;1YIH;1YVQ;1YVT;1YZI;1Z8U;2D5Z;2D60;2DN1;2DN2;2DN3;2DXM;2H35;2HBC;2HBD;2HBE;2HBF;2HBS;2HCO;2HHB;2HHD;2HHE;2M6Z;2W6V;2W72;2YRS;3B75;3D17;3D7O;3DUT;3HHB;3HXN;3IA3;3IC0;3IC2;3KMF;3NL7;3NMM;3ODQ;3ONZ;3OO4;3OO5;3OVU;3P5Q;3QJB;3QJC;3QJD;3QJE;3R5I;3S48;3S65;3S66;3SZK;3WCP;3WHM;4FC3;4HHB;4IJ2;4L7Y;4M4A;4M4B;4MQC;4MQG;4MQH;4MQI;4MQJ;4MQK;4N7N;4N7O;4N7P;4N8T;4NI0;4NI1;4ROL;4ROM;4WJG;4X0L;4XS0;5E29;5E6E;5E83;5EE4;5HU6;5HY8;5JDO;5KDQ;5KSI;5KSJ;5NI1;5SW7;5U3I;5UCU;5UFJ;5URC;5VMM;5WOG;5WOH;5X2R;5X2S;5X2T;5X2U;6BB5;6BNR;6BWP;6BWU;6DI4;6HAL;6HBW;6HK2;6KA9;6KAE;6KAH;6KAI;6KAO;6KAP;6KAQ;6KAR;6KAS;6KAT;6KAU;6KAV;6KYE;6L5V;6L5W;6L5X;6L5Y;6LCW;6LCX;6NBC;6NBD;6NQ5;6TB2;6XD9;6XDT;6XE7;7AET;7AEU;7AEV;7CUE;7DY3;7DY4;7JJQ;7JXZ;7JY0;7JY1;7JY3;7K4M;7PCF;7PCH;7PCQ;7UD7;7UD8;7UF6;7UF7;7VDE; |
 |
Function | Involved in oxygen transport from the lung to the various peripheral tissues. |
Activity data
|
No relevant experimental diagram |
Interaction ID | 424 |
| Target type | Protein | |
| Target unique ID | P69905 | |
| Activity | 7.3 nM | |
| Binding Conditions/Buffer | 10 mM Tris, 100mM NaCl, 2mM CaCl2, 1% BSA |
|
| Assay | N/A |
|
| PubMed ID | 26797251 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_140 | DNA | GGCAGGAAGACAAACACGATGGGGGGGTATGATTTGATGTGGTTGTTGCATGATCGTGGTCTGTGGTGCTGT | |
| Apta_417 | DNA | GGCAGGAAGACAAACACCAGGTGAGGGAGACGACGCGAGTGTTAGATGGTAGCTGTTGGTCTGTGGTGCTGT | |
| Apta_1267 | DNA | GGCACGGCAAAGGGGTACAGCCTACCGAACCGTGGCTGTAAGGGTGGTTGTGGTGTG | |
| Apta_288 | DNA | ATCCAGAGTGACGCAGCATTTCATCGGGTCCAAAAGGGGCTGCTCGGGATTGCGGATATGGACACGT | |
| Apta_1220 | DNA | TGGCGACAAGAAGACGTACAAACACGCACCAGGCCGGAGTGGAGTATTCTGAGGTCGG | |
| Apta_1230 | DNA | GGCGATAGGCAGTGTTGCGGGGTCGGAGAGCGAGGTAATAGCGTGTATGGGTGCTGTGTG | |
| Apta_657 | DNA | CCTGCACCTCGTCCAGCATGCACACCGATGGCGGTCCTGTTTTACGGTAGCTTATATGCAGGGGGTGTGCGTGGGGAGGTGCGGTTGC | |
| Apta_951 | DNA | CACCTAATACGACTCACTATAGCGGATCCGAGGGGGTAGCGGGTGGGCCGGTGGATGCGGGGCGCCGGCGCCTGGCTCGAACAAGCTTGC | |
| Apta_109 | DNA | AGCAGCACAGAGGTCAGATGTGCGACCACCTGGATAGACGAGGGTAGTAAGGAGTGTGTTCCTATGCGTGCTACCGTGA | |
| Apta_109 | DNA | AGCAGCACAGAGGTCAGATGTGCGACCACCTGGATAGACGAGGGTAGTAAGGAGTGTGTTCCTATGCGTGCTACCGTGA | |
| Apta_800 | DNA | AAGGAGCAGCGTGGAGGATATACACCGTCATCAGAGGGAGCATCTCTAGTCAGGACTGTGATGAATTAGGGTGTGTCGTCGTGGT | |
| Apta_223 | DNA | CATTGAGATAGCTAGTTGTAGCTGCGTCATAGGCTGGGTTGGGTCTAGTGGTTGGGTGTG | |
| Apta_1071 | DNA | TTGAAGTGACTCCGCACTGGGTGGGTGGGAGGGTCGTGCGGCTGGTCATAGCAGGGT | |
| Apta_1227 | DNA | CACACCAAACACACAAGTGGACCCTGACGCATGGATAGGGTGACGGTATACGCGGGCATG | |
| Apta_1228 | DNA | GGCCACCAAACCACACCGTCGCAACCGCGAGAACCGAAGTAGTGATCATGTCCCTGCGTG | |
| Apta_1090 | DNA | ATCCAGAGTGACGCAGCAGGGCTTGGGTTGGGAATAAGGATGTGGGAGGCGGCGAACATGGACACGGTGGCTTAGT | |
| Apta_832 | DNA | CCGGAGGTGGGTGAGGTCTGCGGCAGGCTGTGTGGGTGGACCGGAGGGGGGTGAGGTCTGCGGCAGGCTGTGTGGGTGGA | |
| Apta_953 | DNA | TCACCTCATACGACTCACTATAGCGGATCCGAGCCGGGGTGTTCTGTTGGCGGGGGCGGTGGGCGGGCTGGCTCGAACAAGCTTGC | |
| Apta_731 | DNA | AAGGAGCAGCGTGGAGGATACTCTAATTGCCGTATAAGGTCAGGGGGTTGGTTGGTTCCTAGTGCTTAGGGTGTGTCGTCGTGGT | |
| Apta_464 | DNA | GTCAGATTCCACTATAGTAGGTTGGGTAGGGTGGTCGCAGTGGATGATATGTCGTAGGGG |
DEV TOOL
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