Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 625
Aptamer sequence: CTCTCGGGACGACGGCTGGCACGTTTGGTTCAAGAATGTGGGTGTCGTCCC
Target unique ID: 2723872
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_591 | Fructose-bisboronic acid aptamer-sensor | Molecule | D-Fructose | 4 nM | Shinkai's receptor 50 uM with 2% methanol | 25343606 |
Structure information of aptamer
| Aptamer Sequence: | CTCTCGGGACGACGGCTGGCACGTTTGGTTCAAGAATGTGGGTGTCGTCCC |
| The optimal secondary structure in dot-bracket notation: | .....(((((((((.((.(((..((((...))))..))).))))))))))) |
| The centroid secondary structure in dot-bracket notation: | .....(((((((((.((..(((((((.......)))))))))))))))))) |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_591 | Description | Fructose-bisboronic acid aptamer-sensor |
| Aptamer chemistry | DNA | Length | 51 nt |
| GC content | 60.8% | Molecular weight | 15,770.07 Da |
| Molarity of 1 μg/μl solution | 63.41 μM | Number of G-quadruplexes | 2 |
| G-Score | 17 | Function | Aptasensor |
| Sequence | CTCTCGGGACGACGGCTGGCACGTTTGGTTCAAGAATGTGGGTGTCGTCCC | ||
| Applications | Recognition of D-Fructose | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 2723872 | Molecular name | D-Fructose |
| Molecular formula | C6H12O6 | Molecular weight | 180.16 |
| IUPAC name | (3S,4R,5R)-2-(hydroxymethyl)oxane-2,3,4,5-tetrol | InChIKey | LKDRXBCSQODPBY-VRPWFDPXSA-N |
| LogP | -3.22 | Topological polar surface area | 110.38 |
| Hydrogen bond acceptor | 6 | Hydrogen bond donor | 5 |
Synonym(s): D-Arabino-Hex-2-ulo-Pyranose; D-Fru; D-Fructopyranose; D-Fructopyranoside; D-Fructose; Fru; Fructopyranose; Fructopyranoside; Fructose; CHEBI:37714; C6H12O6; [14C]-Fructose; D-arabino-Hex-2-ulopyranose; SCHEMBL239448; CHEMBL2325229; AKOS004910390; F0317; C05003; Q27117234; WURCS=2.0/1,1,0/[ha122h-2x_2-6]/1/; EB37038E-44A6-4AF7-B0D8-47A315AD2F74; (3S,4R,5R)-2-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
Activity data
 |
Interaction ID | 625 |
| Target type | Molecule | |
| Target unique ID | 2723872 | |
| Activity | 4 nM | |
| Binding Conditions/Buffer | Shinkai's receptor 50 uM with 2% methanol |
|
| Assay | The response of sensors |
|
| PubMed ID | 25343606 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_593 | DNA | CTCTCGGGACGACAGCCGAGTTGATTCAACAGCCGAGTCGTCCC | |
| Apta_556 | DNA | GGCTCTCGGGACGACATGGATTTTCCATCAACGAAGTGCGTCCGTCCC | |
| Apta_721 | DNA | CTCTCGGGACGACCGCGGTAGTCTTAACCTAAAGCGGTGTCAGGTCGTCCC | |
| Apta_722 | DNA | CTCTCGGGACGACGGCCCGATCTCAGAGTAGTCGTCCC | |
| Apta_592 | DNA | CTCTCGGGACGACCACTACGCATAGTTTCTATCGCCAGGAAGGGTCGTCCC | |
| Apta_697 | DNA | CTCTCGGGACGACGGACGCTAATCTTACAAGGGCGTAGTGTATGTCGTCCC | |
| Apta_1022 | DNA | CTCCTTCAACGAAGTGGGTTCCTTCAACGAAGTGGGTCTC | |
| Apta_1023 | DNA | CTCCTTCAACGAAGTGGGTCTCCTTCAACGAAGTGGGTCTC | |
| Apta_258 | DNA | CACTGCGGGGGTCTATACGTGAGGAAGAAGTGGGCAGGTC | |
| Apta_340 | DNA | TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA | |
| Apta_960 | DNA | CCCGAGGCACGAGGGGGAACGTATCGTCATGTGCCGGCCA | |
| Apta_1081 | DNA | CTTACGACTGTGGTCGGGTGGTGGGCCTCTAGAGGGGTGTCGTAAG | |
| Apta_150 | DNA | CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG | |
| Apta_835 | DNA | TATGGCGTGGCAAGCTTGGCCCGCTTCTCAAGCATGGTTATCTAC | |
| Apta_1087 | DNA | CTTACGACTCAGGCATTTTGCCGGGTAACGAAGTTACTGTCGTAAG | |
| Apta_1115 | DNA | CGTACGGAATTCGCTAGCGGTGACGGACGTGGGGTGCACGAAGGGAGGGGATCCGAGCTCCACGTG | |
| Apta_1274 | DNA | GACTTCGTCGTCTTTAGACTAGCAGTTAGGGTTTACGATTGTGGAGTTAGCCCCCAGGG | |
| Apta_981 | DNA | TATGGAGAGTCAATGAGTACAGTCTCGTCTCAATAACGGAGCCTCGTCCGTGCCCCCG | |
| Apta_530 | DNA | ATCCGTCACACCTGCTCTGTGTACGCCCGTATTTACGTTCCTAGCAATTGCTATGTGGTGTTGGCTCCCGTAT | |
| Apta_616 | DNA | GGTGCGGGTAGGGATGAGGGCGGGTCGGGTTGAGTGTGAGCTTAGGGGtGGCGGATCTAC |
DEV TOOL
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