Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 530
Aptamer sequence: GGCGGGGCTACGAAGTAGTGATTTTTTCCGATGGCCCGTG
Target unique ID: 36187
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_507 VⅢ Molecule 3,3',4,4'-Tetrachlorobiphenyl 4.02 μM 100 mM NaCl, 20 mM Tris-HCl [pH 7.6], 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, and 0.02% Tween 20 22369896
Structure information of aptamer
Aptamer Sequence: GGCGGGGCTACGAAGTAGTGATTTTTTCCGATGGCCCGTG
The optimal secondary structure in dot-bracket notation: ....(((((((((((.........))).)).))))))...
The centroid secondary structure in dot-bracket notation: .(((.((((((((((.........))).)).)))))))).
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_507 Description VⅢ
Aptamer chemistry DNA Length 40 nt
GC content 57.5% Molecular weight 12,414.95 Da
Molarity of 1 μg/μl solution 80.55 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence GGCGGGGCTACGAAGTAGTGATTTTTTCCGATGGCCCGTG
Applications Biorecognition elements for easy and fast environmental monitoring
Target information
Type Detail Type Detail
PubChem ID 36187 Molecular name 3,3,4,4-Tetrachlorobiphenyl
Molecular formula C12H6Cl4 Molecular weight 292
IUPAC name 1,2-dichloro-4-(3,4-dichlorophenyl)benzene InChIKey UQMGJOKDKOLIDP-UHFFFAOYSA-N
LogP 5.967 Topological polar surface area 0
Hydrogen bond acceptor 0 Hydrogen bond donor 0

Synonym(s):
3,3',4,4'-Tetrachlorobiphenyl; 32598-13-3; PCB 77; 3,4,3',4'-TETRACHLOROBIPHENYL; 3,3',4,4'-Tetrachloro-1,1'-biphenyl; 1,1'-Biphenyl, 3,3',4,4'-tetrachloro-; PCB No 77; 1,2-dichloro-4-(3,4-dichlorophenyl)benzene; Biphenyl, 3,3',4,4'-tetrachloro-; 4-CB; UNII-Y2I6546TMI; 3,4,3',4'-Tetra coplanar polychlorinated biphenyl; CHEBI:1367; CHEMBL344161; Y2I6546TMI; 3,4,3',4'-Tetrachloro-biphenyl; PCB 77 (3,3',4,4'-Tetrachlorobiphenyl); HSDB 3949; CCRIS 8592; PCB-77; 3,3',4,4'-TCB; PCB No. 77; BIDD:ER0452; SCHEMBL137915; DTXSID5022514; 3,3',4,4'-Tetrachlorbiphenyl; PCB No 77, analytical standard; 3,3',4,4'-tetrachlorobinphenyl; ZINC1532135; BDBM50408357; AKOS015903432; MCULE-8977863883; PCB No. 77 10 microg/mL in Isooctane; 3,3',4,4'-Tetrachloro(14C-U)biphenyl; PCB No. 77 100 microg/mL in Isooctane; E78766; 1,1'-Biphenyl, 3,3',4,4'-tetrachloro- (9CI); J-018797; Q26841257; UNII-Z34ZC2K7Q0 component UQMGJOKDKOLIDP-UHFFFAOYSA-N; 3,3',4,4'-Tetrachloro-1,1'-biphenyl labeled with carbon-14; 1,1'-Biphenyl, 3,3',4,4'-tetrachloro-, labeled with carbon-14; 80333-65-9

Activity data
Interaction ID 530
Target type Molecule
Target unique ID 36187
Activity 4.02 μM
Binding Conditions/Buffer

100 mM NaCl, 20 mM Tris-HCl [pH 7.6], 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, and 0.02% Tween 20
Assay

Binding curves and determination of dissociation constants (Kd values) of II, IV, VI, and VIII. Kd values were calculated by nonlinear regression analysis. Error bars represent standard deviations from three repeated experiments
PubMed ID 22369896
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_595 DNA AGCGAGGGCGGTGTCCAACAGCGGTTTTTTCACGAGGAGGTTGGCGGTGG 58.00%
Apta_564 DNA GGGGACTGTTGTGGTATTATTTTTGGTTGTGCAGT 57.50%
Apta_846 DNA GTGCAGACAGCTAGTAGTGGTGACTTTCTGTCCAAATCAAGATAA 55.56%
Apta_158 DNA CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTG 55.00%
Apta_1026 DNA GGGGGGTGTATCGTTGACGAGTTGCGCGTGCGTCTCGTG 55.00%
Apta_1203 DNA CCCTGCGGGGCTACCCGATATGTGTCCGAGTGGTG 55.00%
Apta_1216 DNA AGCGTCCTCTGCATAGTGATTTACGCTATGTGTACAGTGC 55.00%
Apta_1237 DNA GGGGTTGTGTGGGGAGTTTGTCCTGTTGTG 55.00%
Apta_144 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAG 54.55%
Apta_910 DNA TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA 54.55%
Apta_556 DNA GGCTCTCGGGACGACATGGATTTTCCATCAACGAAGTGCGTCCGTCCC 54.17%
Apta_940 DNA TGTGCGGGGGAGGGGAGTGGCGCTGTTGGTGCGGGTATAGCGCGTGGTGT 54.00%
Apta_143 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAGTTTCG 53.06%
Apta_755 DNA GGGGAGGGAGACACAGTCATGGAGCAGTTATTAGGGTGTACCGGGTGTAGT 52.94%
Apta_71 DNA GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC 52.50%
Apta_75 DNA CACTGGTAGGTTGGTGTGGTTGGGGCCAGTG 52.50%
Apta_146 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG 52.50%
Apta_330 DNA GCTGGGTAAATAGATGATTCCCGGC 52.50%
Apta_338 DNA GGGCGCGTTCTTCGTGGTTACTTTTAGTCCCG 52.50%
Apta_339 DNA CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTGT 52.50%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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