Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 534
Aptamer sequence: ATCCGTCACACCTGCTCTCAGGGGATCACATTCTTGACGGTGTGATACAGTGCCTGGTGTTGGCTCCCGTAT
Target unique ID: 187
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_511 ACh 6R Molecule Acetylcholine N/A 0.5 M NaCl, 10 mM Tris HCl, and 1 mM MgCl2 18311508
Structure information of aptamer
Aptamer Sequence: ATCCGTCACACCTGCTCTCAGGGGATCACATTCTTGACGGTGTGATACAGTGCCTGGTGTTGGCTCCCGTAT
The optimal secondary structure in dot-bracket notation: ....((((((((.((.((......((((((((......))))))))..)).))..)))).))))........
The centroid secondary structure in dot-bracket notation: .....(((((((.....(((((..........))))).)))))))......(((.......)))........
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_511 Description ACh 6R
Aptamer chemistry DNA Length 72 nt
GC content 54.2% Molecular weight 22,123.13 Da
Molarity of 1 μg/μl solution 45.20 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence ATCCGTCACACCTGCTCTCAGGGGATCACATTCTTGACGGTGTGATACAGTGCCTGGTGTTGGCTCCCGTAT
Applications Detection of acetylcholine
Target information
Type Detail Type Detail
PubChem ID 187 Molecular name Acetylcholine
Molecular formula C7H16NO2+ Molecular weight 146.21
IUPAC name 2-acetyloxyethyl(trimethyl)azanium InChIKey OIPILFWXSMYKGL-UHFFFAOYSA-N
LogP 0.256 Topological polar surface area 26.3
Hydrogen bond acceptor 2 Hydrogen bond donor 0

Synonym(s):
acetylcholine; Choline acetate; O-Acetylcholine; 51-84-3; (2-Acetoxyethyl)trimethylammonium; Acetyl choline ion; Acetylcholinum; Acetyl choline cation; Ach; Choline acetate (ester); 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 2-acetyloxyethyl(trimethyl)azanium; Azetylcholin; ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; UNII-N9YNS0M02X; BRN 1764436; CHEBI:15355; CHEMBL667; N9YNS0M02X; [2-(acetyloxy)ethyl]trimethylazanium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl- (9CI); 2-acetyloxyethyl-trimethylazanium; [3H]acetylcholine; NCGC00018123-05; EINECS 200-128-9; COL Acetate; 2rin; 3rqw; Acetylcholine cation; (14C)Acetylcholine; (14C)-Acetylcholine; Spectrum_000022; 2ha4; 2xz5; Spectrum2_001258; Spectrum3_000286; Spectrum4_000136; Spectrum5_000762; Epitope ID:176773; cid_6060; SCHEMBL3216; BSPBio_001792; GTPL294; KBioGR_000552; KBioSS_000382; 4-04-00-01446 (Beilstein Handbook Reference); DivK1c_000686; SPBio_001196; Acetylcholinium: acetyl-Choline; GTPL8593; (2-Acetoxyethyl)trimetilammonium; DTXSID8075334; BDBM10759; KBio1_000686; KBio2_000382; KBio2_002950; KBio2_005518; KBio3_001292; NINDS_000686; HMS2089A14; ZINC3079336; NSC800293; DB03128; MCULE-7765616505; NSC-800293; 2-acetyloxy-N,N,N-trimethylethanaminium; IDI1_000686; 2-acetoxyethyl(trimethyl)ammonium;bromide; NCGC00018123-01; NCGC00018123-02; NCGC00018123-03; NCGC00018123-04; NCGC00021161-03; NCGC00021161-04; NCGC00163215-01; SBI-0051271.P003; 2-acetoxyethyl(trimethyl)ammonium;perchlorate; FT-0689161; ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl; 4774-EP2269989A1; 4774-EP2272537A2; 4774-EP2275420A1; 4774-EP2280006A1; 4774-EP2280010A2; 4774-EP2281813A1; 4774-EP2281824A1; 4774-EP2284171A1; 4774-EP2287163A1; 4774-EP2295437A1; 4774-EP2298734A2; 4774-EP2298758A1; 4774-EP2298759A1; 4774-EP2298772A1; 4774-EP2298775A1; 4774-EP2305644A1; 4774-EP2305664A1; 4774-EP2305675A1; 4774-EP2305678A1; 4774-EP2308839A1; 4774-EP2308873A1; 4774-EP2308875A1; 4774-EP2308876A1; 4774-EP2311823A1; 4774-EP2311828A1; 4774-EP2311831A1; 4774-EP2314571A2; 4774-EP2316836A1; C01996; 21686-EP2272972A1; 21686-EP2272973A1; 21686-EP2277872A1; 21686-EP2314571A2; 21686-EP2371803A1; 21686-EP2377843A1; AB00053790-25; AB00053790_26; AB00053790_27; L000783; Q180623; 2-(Acetyloxy)-N,N,N-trimethylethanaminium labeled with carbon-14; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, labeled with carbon-14 (9CI); 14047-05-3

Activity data

No relevant experimental diagram

 Interaction ID 534
Target type Molecule
Target unique ID 187
Activity N/A
Binding Conditions/Buffer

0.5 M NaCl, 10 mM Tris HCl, and 1 mM MgCl2
Assay

N/A
PubMed ID 18311508
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_535 DNA ATCCGTCACACCTGCTCTTGGGGTTATTACTCGTGAGATTGGGAATAGGTTACATGGTGTTGGCTCCCGTAT 75.00%
Apta_536 DNA ATCCGTCACACCTGCTCTCGAATAGAGTACTCGATACTGACTTTATTTACCGTCTGGTGTTGGCTCCCGTAT 75.00%
Apta_826 DNA ATCCGTCACACCTGCTCTGCACGGGCTCAGTTTGGCTTTGTATCCTAAGAGGGATGGTGTTGGCTCCCGTAT 75.00%
Apta_899 DNA ATCCGTCACACCTGCTCTCGAATAGAGTATTCGATACTGACTTTATTTACCGTCTGGTGTTGGCTCCCGTAT 73.61%
Apta_525 DNA ATCCGTCACACCTGCTCTCAATCTGAAATATTGCAAGCAGTGCTCACAATTTGTTGGTGTTGGCTCCCGTAT 72.22%
Apta_532 DNA ATCCGTCACACCTGCTCTAACTTACACATAATTCTAGGTTACATCTTGCTCATATGGTGTTGGCTCCCGTAT 70.83%
Apta_534 DNA ATCCGTCACACCTGCTCTTGTAGGGTTCCCACCCAATTCAGTTCCGTTAAACCATGGTGTTGGCTCCCGTAT 70.83%
Apta_534 DNA ATCCGTCACACCTGCTCTTGTAGGGTTCCCACCCAATTCAGTTCCGTTAAACCATGGTGTTGGCTCCCGTAT 70.83%
Apta_1050 DNA ATCCGTCACACCTGCTCTCACGTCCGTCAACCAGATTGATACTTTATCTTGTTGTGGTGTTGGCTCCCGTAT 70.83%
Apta_530 DNA ATCCGTCACACCTGCTCTGTGTACGCCCGTATTTACGTTCCTAGCAATTGCTATGTGGTGTTGGCTCCCGTAT 69.86%
Apta_523 DNA ATCCGTCACACCTGCTCTGACGCTGGGGTCGACCCGGAGAAATGCATTCCCCTGTGGTGTTGGCTCCCGTAT 69.44%
Apta_524 DNA ATCCGTCACACCTGCTCTGGCATTAGTATTCCATAGCCGGCCAAGTCTATGTAGTGGTGTTGGCTCCCGTAT 69.44%
Apta_529 DNA ATCCGTCACACCTGCTCTACACTCCGCACGATCTTTTTTAGAACGCGTACCCGTTGGTGTTGGCTCCCGTAT 69.44%
Apta_815 DNA CATCCGTCACACCTGCTCTGGCCACTAACATGGGGACCAGGTGGTGTTGGCTCCCGTATC 69.44%
Apta_906 DNA ATCCGTCACACCTGCTCTCCCCGGCGTCCGTTTATTAGCAGACTTTGGCGGAATTGGTGTTGGCTCCCGTAT 68.06%
Apta_1051 DNA ATCCGTCACACCTGCTCTATACACATTGTGTTTACTCCCAGTTTTTTAGACTTATGGTGTTGGCTCCCGTAT 68.06%
Apta_537 DNA ATCCGTCACACCTGCTCTCCTCGAACTAGTTAGACCCTCCTCCAAGTCAACTTGTGGTGTTGGCTCCCGTAT 66.67%
Apta_1052 DNA ATCCGTCACACCTGCTCTATTCCTCTGTTGAAGAACCACTTCCGGAAATAAGAGTGGTGTTGGCTCCCGTAT 65.28%
Apta_572 DNA CCGTAACCCTGCGGGGGGGGGAGAAGGCAATGGGGGACAACTCGCCGGTAGCCATCCATAT 55.56%
Apta_989 DNA ATGCGGGTACATCTCTCCAACCAGTCAAACTGCTATGATAAGACCTCATTCAACCCCGGTA 55.56%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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