Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 529
Aptamer sequence: AAGCGCGCGAGACTACGTTTGTAGGGATACCGATGTCG
Target unique ID: 36187
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_506 Ⅱ Molecule 3,3',4,4'-Tetrachlorobiphenyl 8.32 μM 100 mM NaCl, 20 mM Tris-HCl [pH 7.6], 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, and 0.02% Tween 20 22369896
Structure information of aptamer
Aptamer Sequence: AAGCGCGCGAGACTACGTTTGTAGGGATACCGATGTCG
The optimal secondary structure in dot-bracket notation: ..(((.(((......))).))).((....)).......
The centroid secondary structure in dot-bracket notation: ......................................
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_506 Description Ⅱ
Aptamer chemistry DNA Length 38 nt
GC content 55.3% Molecular weight 11,783.57 Da
Molarity of 1 μg/μl solution 84.86 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence AAGCGCGCGAGACTACGTTTGTAGGGATACCGATGTCG
Applications Biorecognition elements for easy and fast environmental monitoring
Target information
Type Detail Type Detail
PubChem ID 36187 Molecular name 3,3,4,4-Tetrachlorobiphenyl
Molecular formula C12H6Cl4 Molecular weight 292
IUPAC name 1,2-dichloro-4-(3,4-dichlorophenyl)benzene InChIKey UQMGJOKDKOLIDP-UHFFFAOYSA-N
LogP 5.967 Topological polar surface area 0
Hydrogen bond acceptor 0 Hydrogen bond donor 0

Synonym(s):
3,3',4,4'-Tetrachlorobiphenyl; 32598-13-3; PCB 77; 3,4,3',4'-TETRACHLOROBIPHENYL; 3,3',4,4'-Tetrachloro-1,1'-biphenyl; 1,1'-Biphenyl, 3,3',4,4'-tetrachloro-; PCB No 77; 1,2-dichloro-4-(3,4-dichlorophenyl)benzene; Biphenyl, 3,3',4,4'-tetrachloro-; 4-CB; UNII-Y2I6546TMI; 3,4,3',4'-Tetra coplanar polychlorinated biphenyl; CHEBI:1367; CHEMBL344161; Y2I6546TMI; 3,4,3',4'-Tetrachloro-biphenyl; PCB 77 (3,3',4,4'-Tetrachlorobiphenyl); HSDB 3949; CCRIS 8592; PCB-77; 3,3',4,4'-TCB; PCB No. 77; BIDD:ER0452; SCHEMBL137915; DTXSID5022514; 3,3',4,4'-Tetrachlorbiphenyl; PCB No 77, analytical standard; 3,3',4,4'-tetrachlorobinphenyl; ZINC1532135; BDBM50408357; AKOS015903432; MCULE-8977863883; PCB No. 77 10 microg/mL in Isooctane; 3,3',4,4'-Tetrachloro(14C-U)biphenyl; PCB No. 77 100 microg/mL in Isooctane; E78766; 1,1'-Biphenyl, 3,3',4,4'-tetrachloro- (9CI); J-018797; Q26841257; UNII-Z34ZC2K7Q0 component UQMGJOKDKOLIDP-UHFFFAOYSA-N; 3,3',4,4'-Tetrachloro-1,1'-biphenyl labeled with carbon-14; 1,1'-Biphenyl, 3,3',4,4'-tetrachloro-, labeled with carbon-14; 80333-65-9

Activity data
Interaction ID 529
Target type Molecule
Target unique ID 36187
Activity 8.32 μM
Binding Conditions/Buffer

100 mM NaCl, 20 mM Tris-HCl [pH 7.6], 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, and 0.02% Tween 20
Assay

Binding curves and determination of dissociation constants (Kd values) of II, IV, VI, and VIII. Kd values were calculated by nonlinear regression analysis. Error bars represent standard deviations from three repeated experiments
PubMed ID 22369896
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_702 DNA TACCCGGCGTTCGGGGGGTACCGCTGC 57.89%
Apta_1269 DNA TAGCACACAACCCTTTGATTGGGATATCTCATCCCTCG 57.89%
Apta_733 DNA TAGGCAGTGGTTTGACGTCCGCATGTTGGGAATAGCCACGCCT 55.81%
Apta_585 DNA GATCGAGGGCAGCGATAGCTGGGCTAATAAGGTTAGCCCCATCGGTC 55.32%
Apta_146 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG 55.26%
Apta_679 DNA CAGGTGGCAGATCGGGTGTGGGTGGCCTGG 55.26%
Apta_700 DNA GCAGGGGCGTTCGGGGGGTACCGCTGC 55.26%
Apta_781 DNA GTACGCCGCAAGACGAGTTGTGTATAAGCCGGC 55.26%
Apta_1019 DNA ATCCCTGCAGTTTGGTAGGGTGCAGG 55.26%
Apta_1258 DNA GGCGAAGGAGTCATGTAGGTGTGGTCGAGACCGCTGTGCT 55.00%
Apta_755 DNA GGGGAGGGAGACACAGTCATGGAGCAGTTATTAGGGTGTACCGGGTGTAGT 54.90%
Apta_940 DNA TGTGCGGGGGAGGGGAGTGGCGCTGTTGGTGCGGGTATAGCGCGTGGTGT 54.00%
Apta_779 DNA TACGGGCTGGATCCACTGTTACGGCGTGTATCCGCTATCAA 53.66%
Apta_484 DNA CAGGGAGGGACAGGGCGGGAATTTGTATGATGGTTCGTTTGCTCG 53.33%
Apta_821 DNA CACAGTCACTCAGACGGCCGCTATTGTTGCCAGATTGCCTTTGGC 53.33%
Apta_1162 DNA AGAGGCTACAGCGATAAGTCGACATTGCTGACCGTACCTAGTAATACGT 53.06%
Apta_591 DNA CTCTCGGGACGACGGCTGGCACGTTTGGTTCAAGAATGTGGGTGTCGTCCC 52.94%
Apta_621 DNA AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC 52.73%
Apta_63 DNA GACCCGTGGTAGGGTAGGATGGGGTGGTC 52.63%
Apta_74 DNA GGACAGTAGGTTGGTGTGGTTGGGGCTGTCC 52.63%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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