Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 572
Aptamer sequence: ACGTGTTGTCTCTCTGTGTCTCGT
Target unique ID: 186907
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_540 Apt-3bp Molecule Aflatoxin B1 10 nM (1× PBS, pH 7.5) contained 137 mM NaCl, 2.7 mM KCl, 10 mM Na2HPO4, and 1.75 mM KH2PO4 33052655
Structure information of aptamer
Aptamer Sequence: ACGTGTTGTCTCTCTGTGTCTCGT
The optimal secondary structure in dot-bracket notation: ........................
The centroid secondary structure in dot-bracket notation: ........................
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_540 Description Apt-3bp
Aptamer chemistry DNA Length 24 nt
GC content 50.0% Molecular weight 7,307.69 Da
Molarity of 1 μg/μl solution 136.84 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence ACGTGTTGTCTCTCTGTGTCTCGT
Applications Sensor for Aflflatoxin B1
Target information
Type Detail Type Detail
PubChem ID 186907 Molecular name Aflatoxin B1
Molecular formula C17H12O6 Molecular weight 312.27
IUPAC name (3S,7R)-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione InChIKey OQIQSTLJSLGHID-WNWIJWBNSA-N
LogP 2.277 Topological polar surface area 74.97
Hydrogen bond acceptor 6 Hydrogen bond donor 0

Synonym(s):
AFLATOXIN B1; 1162-65-8; AFB1; UNII-9N2N2Y55MH; NSC-529592; 1H,11H-Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-4-methoxy-, (6aR,9aS)-; AFBI; 9N2N2Y55MH; CHEBI:2504; 2,3,6aalpha,9aalpha-Tetrahydro-4-methoxycyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione; MFCD00869647; (6aR,9aS)-4-methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione; Aflatoxin B; (3S,7R)-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione; NSC 529592; HSDB 3453; NSC529592; CCRIS 12; Aflatoxin B1 2 microg/mL in Acetonitrile; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR,9aS)-; EINECS 214-603-3; BRN 1269174; Aflatoxin B1 from Aspergillus flavus, from Aspergillus flavus; (+/-)-Aflatoxin B1; BIDD:ER0313; SCHEMBL126480; Aflatoxin B1 Standard Solution; CHEMBL1697694; DTXSID9020035; Aflatoxin B1, reference material; DTXSID00873175; BDBM120261; ZINC402671; AMY22311; EX-A5480; HY-N6615; AKOS030241596; VA10187; NCGC00247669-01; 2,3,6aalpha,9aalpha-Tetrahydro-4-methoxycyclopenta(c)furo(2',3':4,5)furo(2,3-h)chromene-1,11-dione; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6aalpha,9aalpha-tetrahydro-4-methoxy-; CS-0034371; 162A658; Q4689278; WLN: T F5 C6 B655 DOV GV OO QO RUT&&TTJ LO1; Aflatoxin B1 solution, 20 mug/mL in methanol, analytical standard; Aflatoxin B1 solution, 2 mug/mL in acetonitrile, analytical standard; Aflatoxin B1 solution, 3 mug/mL in benzene:acetonitrile (98:2), analytical standard; Aflatoxin B1 solution, 3.79 mug/g in acetonitrile, ERM(R) certified Reference Material; Aflatoxin B1 solution, certified reference material, 20 mug/mL in methanol, ampule of 1 mL; 10279-73-9; Aflatoxin B1 solution, certified reference material, 3 mug/mL in benzene:acetonitrile (98:2), ampule of 1 mL; Cyclopenta[c]furo[3',5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-; Cyclopenta[c]furo[3',5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-; Cyclopenta[c]furo[3',5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a.alpha.,9a.alpha.-tetrahydro-4-methoxy-

Activity data
Interaction ID 572
Target type Molecule
Target unique ID 186907
Activity 10 nM
Binding Conditions/Buffer

(1× PBS, pH 7.5) contained 137 mM NaCl, 2.7 mM KCl, 10 mM Na2HPO4, and 1.75 mM KH2PO4
Assay

Comparison of electrochemical Aptasensors using aptamers with different stem lengths ranging from 1 to 6 bp in responses to AFB1
PubMed ID 33052655
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_541 DNA CACGTGTTGTCTCTCTGTGTCTCGTG
92.31%
Apta_539 DNA CGTGTTGTCTCTCTGTGTCTCG
91.67%
Apta_542 DNA GCACGTGTTGTCTCTCTGTGTCTCGTGC
85.71%
Apta_538 DNA GTGTTGTCTCTCTGTGTCTC
83.33%
Apta_543 DNA GGCACGTGTTGTCTCTCTGTGTCTCGTGCC 80.00%
Apta_1083 DNA TGCTGTTGTCACCTGCCTCGTCTCCCTCGT 63.33%
Apta_147 DNA TGCGGTTGTAGTACTCGTGGCCG 58.33%
Apta_69 DNA AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT 58.06%
Apta_1210 DNA GGGGAGGCAGTGTGTTGTGTCGTGTGTGTGCTTGG 57.14%
Apta_191 DNA AGGAAGGCTTTACCTCTGAGATCTCGGAAT 56.67%
Apta_192 DNA AGGAAGGCTTTAGCTCTGAGATCTCGGAAT 56.67%
Apta_202 DNA AAGGCTTTAGGTCTGAGATCTCGGAAT 55.56%
Apta_1204 DNA GGCACGATGTGGCTACATCGATCGCGGTACTGGTG 54.29%
Apta_1204 DNA GGCACGATGTGGCTACATCGATCGCGGTACTGGTG 54.29%
Apta_203 DNA GGAAGGCTTTAGGTCTGAGATCTCGG 53.85%
Apta_205 DNA TTAAGGCTTTAGGTCTGAGATCTCTT 53.85%
Apta_184 DNA AGGAAGGCTTTAGGTCTGAGATCTCGGAAT 53.33%
Apta_186 DNA AGGAACGCTTTAGGTCTGAGATCTCGGAAT 53.33%
Apta_189 DNA AGGAACCCTTTACCTCTGAGATCTCGGAAT 53.33%
Apta_675 DNA ACTGTCCGTCGGGTTTAGGGTGGCGTTCGG 53.33%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

HELP CENTER

>Contact us
>LMMD Group
>School of Pharmacy

DEV TOOL
Page last updated at 2022-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 43982
Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.