AptaDB: Result

Interaction ID: 1248

Aptamer sequence: AGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT

Target unique ID: Q06124

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1186	SH-HJ24-bio	Protein	PTN11_HUMAN	N/A	N/A	22924632

Aptamer Sequence:	AGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT
The optimal secondary structure in dot-bracket notation:	....(((((.....((((.(((...))).))))......)))))
The centroid secondary structure in dot-bracket notation:	....(((((..............................)))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1186	Description	SH-HJ24-bio
Aptamer chemistry	DNA	Length	44 nt
GC content	68.2%	Molecular weight	13,961.86 Da
Molarity of 1 μg/μl solution	71.62 μM	Number of G-quadruplexes	4
G-Score	76	Function	Targeted binding
Sequence	AGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT
Applications	Binding to shp2

Type	Detail	Type	Detail
Uniprot ID	Q06124	Protein name	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene name(s)	PTPN11 PTP2C SHPTP2	Organism	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Status	reviewed in uniprot database	Length	593
Mass	68,011	Activity regulation	N/A
Involvement in disease	LEOPARD syndrome 1 (LPRD1)	Catalytic activity	Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
PDB ID(s)	2SHP;3B7O;3MOW;3O5X;3TKZ;3TL0;3ZM0;3ZM1;3ZM2;3ZM3;4DGP;4DGX;4GWF;4H1O;4H34;4JE4;4JEG;4JMG;4NWF;4NWG;4OHD;4OHE;4OHH;4OHI;4OHL;4PVG;4QSY;4RDD;5BK8;5DF6;5EHP;5EHR;5I6V;5IBM;5IBS;5X7B;5X94;5XZR;6ATD;6BMR;6BMU;6BMV;6BMW;6BMX;6BMY;6BN5;6CMP;6CMQ;6CMR;6CMS;6CRF;6CRG;6MD7;6MD9;6MDA;6MDB;6MDC;6MDD;6R5G;6WU8;7EMN;7JVM;7JVN;7R75;7R7D;7R7I;7R7L;7RCT;7VXG;
Function	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

	Interaction ID	1248
	Target type	Protein
	Target unique ID	Q06124
	Activity	N/A
	Binding Conditions/Buffer	N/A
	Assay	Typical force curves of dual-labeled G-quadruplex in solution
	PubMed ID	22924632

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1185	DNA	CAGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT	97.78%
Apta_1014	DNA	TGGGGGTTGGGTGGATAGGCTGGCGTCGGGGCAGGTCAGT	61.36%
Apta_264	DNA	GGCGTTGTCGGGCGCAGGTGTAGGCCTCGTGGTGGTGGGT	59.09%
Apta_565	DNA	GCGGGGTTGGGCGGGTGGGTTCGCTGGGCAGGGGGCGAGTG	59.09%
Apta_263	DNA	AGAGGGGAGGGTCGGGTATCGGCGTGTTCGGGGGATCTGC	56.82%
Apta_482	DNA	AGCAAGGTTTGGTGTTGGTTGGTTGCTGGTTTTGGTTTC	56.82%
Apta_493	DNA	GGGGTGGTGGGTTCTTTTTGTGGTATTGGTGTGGGGGGCA	56.82%
Apta_869	DNA	ACTAGGACGCTTGGGAGGGGGGGTGGGGTGTCCGGTCGCG	56.82%
Apta_1085	DNA	TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC	56.82%
Apta_1189	DNA	GCGGGCGGGGGGAGGGCGGCCGTGGGCTGCGAGTGGGAGG	56.82%
Apta_1195	DNA	GGGGTTGGGGGGAGGCGGGGAATGGGGG	56.82%
Apta_1237	DNA	GGGGTTGTGTGGGGAGTTTGTCCTGTTGTG	56.82%
Apta_616	DNA	GGTGCGGGTAGGGATGAGGGCGGGTCGGGTTGAGTGTGAGCTTAGGGGtGGCGGATCTAC	56.67%
Apta_596	DNA	GGTGGCTGTTGGTCGAGGCTTATTAGTGTAGTCAATGGAGGCAGGCGACG	56.00%
Apta_756	DNA	GGGGGACACGGAGGTGGTGGAAAGGCTAAGATTTGATGATGAGTAGTGTGGT	55.77%
Apta_223	DNA	CATTGAGATAGCTAGTTGTAGCTGCGTCATAGGCTGGGTTGGGTCTAGTGGTTGGGTGTG	55.00%
Apta_10	DNA	GGGGGGGGTGGCTGGGCGGGGTGGG	54.55%
Apta_13	DNA	AGGGGGGGGGGAGGGGTCGGGGTGG	54.55%
Apta_14	DNA	AGCGGGGGGGGCTGGGCTGGGTGGG	54.55%
Apta_41	DNA	CGGTCGCTCCGTGTGGCTTGGGTTGGGTGTGGCAGTGAC	54.55%

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