Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 466
Aptamer sequence: CGCTCGGCTTCACGAGATTCGTGTCGTTGTGTCCTGTACCCGCCTTGACCAGTCACTCTAGAGCATCCGGACTG
Target unique ID: Q4LDM3
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_461 T18_1_3 Protein Q4LDM3_CAPCA 94 nM PBS with 1 MgCl2 18294846
Structure information of aptamer
Aptamer Sequence: CGCTCGGCTTCACGAGATTCGTGTCGTTGTGTCCTGTACCCGCCTTGACCAGTCACTCTAGAGCATCCGGACTG
The optimal secondary structure in dot-bracket notation: ....((((..(((((...)))))..)))).((((.......((((.((........)).)).))....))))..
The centroid secondary structure in dot-bracket notation: ....((((..(((((...)))))..))))............(((................).))..........
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_461 Description T18_1_3
Aptamer chemistry DNA Length 74 nt
GC content 58.1% Molecular weight 22,662.45 Da
Molarity of 1 μg/μl solution 44.13 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence CGCTCGGCTTCACGAGATTCGTGTCGTTGTGTCCTGTACCCGCCTTGACCAGTCACTCTAGAGCATCCGGACTG
Applications Targeting TGF-b1 protein
Target information
Type Detail Type Detail
Uniprot ID Q4LDM3 Protein name Transforming growth factor b1 (Fragment)
Gene name(s) TGF-b1 Organism Transforming growth factor b1 (Fragment)
Status unreviewed in uniprot database Length 50
Mass 6,012 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
N/A
Function N/A
Activity data
Interaction ID 466
Target type Protein
Target unique ID Q4LDM3
Activity 94 nM
Binding Conditions/Buffer

PBS with 1 MgCl2
Assay

Multimerization of thioaptamer T18_1_3
PubMed ID 18294846
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_555 DNA TGTACCGTCTGAGCGATTCGTACGGATTGGGTTTGCACTTTACCTGCGGTGCATCGCAGCCAGTCAGTGTTAAGGAGTGC 56.25%
Apta_762 DNA AGCAGAGTTCACGACCCGATAAGGGCGATGCCGATCCCTGTGGCCGTAGGGACAGTCCCGCTAGAGTTACATACCAATCGTCGCAG 55.81%
Apta_760 DNA AGCAGAGTTCACGACCCGATAAGGGCGATGCCGATCCCTGTGGCCGTAGGGGCAGTCCCGCTAGAGTTACATACCAATCGTCGCAG 54.65%
Apta_801 DNA TGCGTGTGTAGTGTGTCTGCATGCCCCTGTAATCGCCCATGGGTAGCCTCTTAGGGATTTGGGCGG 54.05%
Apta_1234 DNA TGTACCGTCTGAGCGATTCGTACTGTGGGCACCAATCGTACCCAATACTTGCGAATCAGCCAGTCAGTGTTAAGGAGTGC 53.75%
Apta_554 DNA TGTACCGTCTGAGCGATTCGTACCATTAGTGGGTGCTCCTTACCTGATGGTCATCTAGCCAGTCAGTGTTAAGGAGTGC 53.16%
Apta_596 DNA GGTGGCTGTTGGTCGAGGCTTATTAGTGTAGTCAATGGAGGCAGGCGACG 52.70%
Apta_1045 DNA GGTGCTCAGGGAACTGTCTGAGGGATCAGGCTTAAGCCTGTCGAGCAGTT 52.70%
Apta_1116 DNA CGTACGGAATTCGCTAGCCGGGGTGGGAACCAGTCTTGCGCGGGTGACGGATCCGAGCTCCACGTG 52.70%
Apta_1117 DNA CGTACGGAATTCGCTAGCGGACTGGAGTCTAGACCGGGTAGCTGTGGTGGATCCGAGCTCCACGTG 52.70%
Apta_1111 DNA GTGCGTCGCATGATCGCGATTAGTGCGACCATGTACGATTCTCACGACAACGACACTGTACTTGAGGACTGTCTCC 52.63%
Apta_1178 DNA AGCGTCGAATACCACTACAGGGGATGCGAAGTTCCGCGGTCGAGTATATGATACATCCATCTAATGGAGCTCGTGGTCAG 52.50%
Apta_1235 DNA TGTACCGTCTGAGCGATTCGTACGATCGGGTCGGGGTCTATTTTAGGGCCATTTGGCAGCCAGTCAGTGTTAAGGAGTGC 52.50%
Apta_553 DNA TGTACCGTCTGAGCGATTCGTACGAACGGCTTTGTACTGTTTGCACTGGCGGATTTAGCCAGTCAGTGTTAAGGAGTGC 51.90%
Apta_143 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAGTTTCG 51.35%
Apta_144 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAG 51.35%
Apta_239 DNA CCCAGATTACTGTGGAGTGGTTGTCTGCGAATCCTTCGTCCACCCAATAG 51.35%
Apta_344 DNA CACTACAGAGGTTGCGTCTGTCCCACGTTGTCATGGGGGGTTGGCCTG 51.35%
Apta_653 DNA CCTGCACCTCGTCCAGCATCCGATGGCGGTCCTGTTTTACGGTAGCTTATATGCAGGGGGGTG 51.35%
Apta_734 DNA TCCTCGATGCACCAGTTCACCTTATTTGCTTCTTCTCTCTGTTCTGACTGGGTGCTGAGGA 51.35%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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