AptaDB: Result

Interaction ID: 430

Aptamer sequence: UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG

Target unique ID: Q01279

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_424	E03	Protein	EGFR_MOUSE	29 nM	1X DPBS, 5 mM MgCl2, pH 7.1-7.5	21687663

Aptamer Sequence:	UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG
The optimal secondary structure in dot-bracket notation:	.(((...((((.((((((.........))))......))))))...)))..
The centroid secondary structure in dot-bracket notation:	.(((...((((.((((((.........))))......))))))...)))..

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_424	Description	E03
Aptamer chemistry	RNA	Length	51 nt
GC content	45.1%	Molecular weight	16,378.78 Da
Molarity of 1 μg/μl solution	61.05 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG
Applications	Be used to escort other anti-tumor or contrast agents

Type	Detail	Type	Detail
Uniprot ID	Q01279	Protein name	Epidermal growth factor receptor (EC 2.7.10.1)
Gene name(s)	Egfr	Organism	Epidermal growth factor receptor (EC 2.7.10.1)
Status	reviewed in uniprot database	Length	1210
Mass	134,853	Activity regulation	Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms
Involvement in disease	N/A	Catalytic activity	Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
PDB ID(s)	N/A
Function	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.

	Interaction ID	430
	Target type	Protein
	Target unique ID	Q01279
	Activity	29 nM
	Binding Conditions/Buffer	1X DPBS, 5 mM MgCl2, pH 7.1-7.5
	Assay	Binding constants for Aptamers E03, E04, and E07
	PubMed ID	21687663
	Interaction ID	506
	Target type	Protein
	Target unique ID	Q9H6S3
	Activity	3 nM
	Binding Conditions/Buffer	1X DPBS, 5 mM MgCl2, pH 7.1-7.5
	Assay	Binding constants for Aptamers E03, E04, and E07
	PubMed ID	21687663

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_425	RNA	UGCCGCCAUAUCACACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG	90.20%
Apta_426	RNA	UGCCGCUAUAAUGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG	90.20%
Apta_92	RNA	ACAACUUAAUGCGACGUUGGUAAAGCAUAUCAAAC	52.94%
Apta_383	RNA	GGCGUGACCUGAUGAGUCACGCUAAGGAGGAUUUCCGAAAGCGGCUACGGUCCGCCAGUGUUACGAAACGUUCCC	52.00%
Apta_707	RNA	GGCCUAAAACAUACCAGAUUUCGAUCUGGAGAGGUGAAGAAUUCGACCACCUAGGCCGGU	51.67%
Apta_658	RNA	CUGCGAUCAGGGGUAAAUUUCCGCGCAGGCUCCACGCCGC	50.98%
Apta_709	RNA	AGUGAUACCAGCAUCGUCUUGAUGCCCUUGGCAGCACU	50.98%
Apta_758	RNA	GGCUUUCGGGCUUUCGGCAACAUCAGCCCCUCAGCC	50.98%
Apta_1140	RNA	UAGUGUGAGAGCCGUGAGUGAAAGGCCGCGACAAAGAUCGGA	50.98%
Apta_1248	RNA	GGGUGACUUUUCCCUCAGGCUCCUGUGAAGCAACCGAAUGGACUGAAAUGAAACCGCCC	50.85%
Apta_53	RNA	UCCCUGGCCCAAGAUCCUAAUAAAGUUUUUUCGGACCGGAGCGAAACCACUAUCCUCUUAAGCAAUCUGU	50.00%
Apta_130	RNA	GGGAGGACGAUGCGGUGGUAGCGCGAUAUAGCGCUGGUAGGGUUGCCGGUGAUCAGACGACUCGCCCGA	49.28%
Apta_718	RNA	GGGUUGUGAGCUCCCGGCUCGCAUUGUGAGGUGGAGGGGGACGUGCUGCAGGUCGACGCAUGCGCCG	49.25%
Apta_447	RNA	ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC	49.12%
Apta_51	RNA	GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC	49.02%
Apta_85	RNA	UGCGACUGUUAUAACCUAACAGCGACGUAAAGAUA	49.02%
Apta_88	RNA	AAUAACCUUAAUGCGACGUUGGUUUGUCAACAACG	49.02%
Apta_96	RNA	UCGCUAAUUAUAGGCGGAGUGCGACGUUAUAAAUA	49.02%
Apta_241	RNA	GCUUGACGGAGAUCAAGGGCGAGUCUCAUACCAAGUUGAUGGGG	49.02%
Apta_243	RNA	GCUUGAAGCUAGCAGUAAGACUAGCGCUACGGAUGGGUGUGCG	49.02%

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