AptaDB: Result

Interaction ID: 272

Aptamer sequence: GAGTGCGTAATGGTACGATTTGGGAAGTGGCTTGGGGTGG

Target unique ID: P08637

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_267	CLN0004	Protein	FCG3A_HUMAN	11 nM	DPBS with 0.05% BSA	21531729

Aptamer Sequence:	GAGTGCGTAATGGTACGATTTGGGAAGTGGCTTGGGGTGG
The optimal secondary structure in dot-bracket notation:	..((((......))))........................
The centroid secondary structure in dot-bracket notation:	..((((......))))........................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_267	Description	CLN0004
Aptamer chemistry	DNA	Length	40 nt
GC content	55.0%	Molecular weight	12,839.01 Da
Molarity of 1 μg/μl solution	77.89 μM	Number of G-quadruplexes	2
G-Score	20	Function	Targeted binding
Sequence	GAGTGCGTAATGGTACGATTTGGGAAGTGGCTTGGGGTGG
Applications	Binding to target proteins

Type	Detail	Type	Detail
Uniprot ID	P08637	Protein name	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Gene name(s)	FCGR3A CD16A FCG3 FCGR3 IGFR3	Organism	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Status	reviewed in uniprot database	Length	254
Mass	29,089	Activity regulation	N/A
Involvement in disease	Immunodeficiency 20 (IMD20)	Catalytic activity	N/A
PDB ID(s)	3AY4;3SGJ;3SGK;3WN5;5BW7;5D6D;5ML9;5MN2;5VU0;5XJE;5XJF;5YC5;7SEG;
Function	Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).

No relevant experimental diagram	Interaction ID	272
	Target type	Protein
	Target unique ID	P08637
	Activity	11 nM
	Binding Conditions/Buffer	DPBS with 0.05% BSA
	Assay	N/A
	PubMed ID	21531729

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_350	DNA	GGTGGTGGTGGTTGTGGTGGTGGTGG	60.00%
Apta_746	DNA	AGAGTGGGGGGGTGGGTGGATTTGACAGGTGGCATGCTGGAGAGT	60.00%
Apta_1247	DNA	GGTGGTTGCTGTTGTTTGTGGTTGGTGTGC	60.00%
Apta_146	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG	57.50%
Apta_493	DNA	GGGGTGGTGGGTTCTTTTTGTGGTATTGGTGTGGGGGGCA	57.50%
Apta_673	DNA	GCAGTCCTAGATCGGGTGTGGCTGGCTTGG	57.50%
Apta_679	DNA	CAGGTGGCAGATCGGGTGTGGGTGGCCTGG	57.50%
Apta_682	DNA	CCTTGTAGATCGGGTGTGGTTTGGCGTAGG	57.50%
Apta_929	DNA	GAGTGGGATGGATAGAGAATAAGTGTGGAGTGGAAGGTGA	57.50%
Apta_144	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAG	56.82%
Apta_971	DNA	TAGTCTAGGAACGGTACGATCGTATTCCAAGGACTTTGCTGGTGGTATCC	56.00%
Apta_972	DNA	TGACAGTACGTACTGAACTAATTTATAAGTAATTTGCTATGGTGGTATCC	56.00%
Apta_744	DNA	GTGGCCAGTCACTCAATTGGGTGTAGGGGTGGGGATTGTGGGTTG	55.56%
Apta_751	DNA	GGTCGCAGATGGATTAAGTATGTGGGTGGGGGGGTGGAAGTTAAT	55.56%
Apta_13	DNA	AGGGGGGGGGGAGGGGTCGGGGTGG	55.00%
Apta_62	DNA	AGTCCGTGGTAGGGCAGGTTGGGGTGACT	55.00%
Apta_69	DNA	AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT	55.00%
Apta_71	DNA	GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC	55.00%
Apta_72	DNA	AGTCAGTAGGTTGGTGTGGTTGGGGCTGACT	55.00%
Apta_364	DNA	TATGGTATGCTGTGTGGTATGGGGTGGCGTGCTCT	55.00%

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