Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 125
Aptamer sequence: GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC
Target unique ID: P01308
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_124 IBA Protein INS_HUMAN N/A 50 mM Tris-HCl, 10 mM KCl, 100 mM NaCl 21874167
Structure information of aptamer
Aptamer Sequence: GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC
The optimal secondary structure in dot-bracket notation: .......(((((.(((.....))).)))))
The centroid secondary structure in dot-bracket notation: ........((((.............)))).
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_124 Description IBA
Aptamer chemistry DNA Length 30 nt
GC content 66.7% Molecular weight 9,732.99 Da
Molarity of 1 μg/μl solution 102.74 μM Number of G-quadruplexes 2
G-Score 21 Function Target detection
Sequence GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC
Applications Detection of insulin
Target information
Type Detail Type Detail
Uniprot ID P01308 Protein name Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Gene name(s) INS Organism Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Status reviewed in uniprot database Length 110
Mass 11,981 Activity regulation N/A
Involvement in disease Hyperproinsulinemia (HPRI) Catalytic activity N/A
PDB ID(s)
1A7F;1AI0;1AIY;1B9E;1BEN;1EFE;1EV3;1EV6;1EVR;1FU2;1FUB;1G7A;1G7B;1GUJ;1HIQ;1HIS;1HIT;1HLS;1HTV;1HUI;1IOG;1IOH;1J73;1JCA;1JCO;1JK8;1K3M;1KMF;1LKQ;1LPH;1MHI;1MHJ;1MSO;1OS3;1OS4;1Q4V;1QIY;1QIZ;1QJ0;1RWE;1SF1;1SJT;1SJU;1T0C;1T1K;1T1P;1T1Q;1TRZ;1TYL;1TYM;1UZ9;1VKT;1W8P;1XDA;1XGL;1XW7;1ZEG;1ZEH;1ZNJ;2AIY;2C8Q;2C8R;2CEU;2G54;2G56;2H67;2HH4;2HHO;2HIU;2JMN;2JUM;2JUU;2JUV;2JV1;2JZQ;2K91;2K9R;2KJJ;2KJU;2KQP;2KQQ;2KXK;2L1Y;2L1Z;2LGB;2LWZ;2M1D;2M1E;2M2M;2M2N;2M2O;2M2P;2MLI;2MPG;2MPI;2MVC;2MVD;2N2V;2N2W;2N2X;2OLY;2OLZ;2OM0;2OM1;2OMG;2OMH;2OMI;2OMQ;2QIU;2R34;2R35;2R36;2RN5;2VJZ;2VK0;2W44;2WBY;2WC0;2WRU;2WRV;2WRW;2WRX;2WS0;2WS1;2WS4;2WS6;2WS7;3AIY;3BXQ;3E7Y;3E7Z;3EXX;3FQ9;3HYD;3I3Z;3I40;3ILG;3INC;3IR0;3JSD;3KQ6;3P2X;3P33;3Q6E;3ROV;3TT8;3U4N;3UTQ;3UTS;3UTT;3V19;3V1G;3W11;3W12;3W13;3W7Y;3W7Z;3W80;3ZI3;3ZQR;3ZS2;3ZU1;4AIY;4AJX;4AJZ;4AK0;4AKJ;4CXL;4CXN;4CY7;4EFX;4EWW;4EWX;4EWZ;4EX0;4EX1;4EXX;4EY1;4EY9;4EYD;4EYN;4EYP;4F0N;4F0O;4F1A;4F1B;4F1C;4F1D;4F1F;4F1G;4F4T;4F4V;4F51;4F8F;4FG3;4FKA;4GBC;4GBI;4GBK;4GBL;4GBN;4IUZ;4IYD;4IYF;4NIB;4OGA;4P65;4RXW;4UNE;4UNG;4UNH;4WDI;4XC4;4Y19;4Y1A;4Z76;4Z77;4Z78;5AIY;5BOQ;5BPO;5BQQ;5BTS;5C0D;5CJO;5CNY;5CO2;5CO6;5CO9;5E7W;5EMS;5EN9;5ENA;5HPR;5HPU;5HQI;5HRQ;5HYJ;5MAM;5MHD;5MT3;5MT9;5MWQ;5T7R;5UDP;5UOZ;5UQA;5URT;5URU;5USP;5USS;5USV;5UU2;5UU3;5UU4;5VIZ;5WBT;5WDM;5WOB;6B3Q;6B70;6BFC;6CE7;6CE9;6CEB;6CK2;6GNQ;6GV0;6H3M;6HN5;6JK8;6JR3;6K59;6NWV;6O17;6P4Z;6S34;6S4I;6S4J;6SOF;6TC2;6TYH;6U46;6VEP;6VER;6VES;6VET;6X4X;6Z7W;6Z7Y;7BW7;7BW8;7BWA;7JP3;7MD4;7MD5;7MQO;7MQR;7MQS;7NHU;7PG0;7PG2;7PG3;7PG4;7QID;7S4Y;7SL1;7SL2;7SL3;7SL4;7SL6;7SL7;7STH;7STI;7STJ;7STK;
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids.
Activity data

No relevant experimental diagram

 Interaction ID 125
Target type Protein
Target unique ID P01308
Activity N/A
Binding Conditions/Buffer

50 mM Tris-HCl, 10 mM KCl, 100 mM NaCl
Assay

N/A
PubMed ID 21874167
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_25 DNA TGTGGGGGTGGTTGGGCGGGGCTGC 70.00%
Apta_350 DNA GGTGGTGGTGGTTGTGGTGGTGGTGG 66.67%
Apta_1085 DNA TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC 66.67%
Apta_15 DNA TGAGGGGGGGGGAGGGCGGGGCTGC 63.33%
Apta_17 DNA AGGGGGGGGGGTGGGGGTGGGTCCC 63.33%
Apta_19 DNA TGAGGGGGGGGGAGGTCGGGCCTGC 63.33%
Apta_20 DNA AGAGGGGGGGGTGGGGGTGGCCTGC 63.33%
Apta_22 DNA TGTGGGGGTGGACTGGGTGGGTACC 63.33%
Apta_757 DNA GGTGGTGGTGGTTGTGGTGGTGG 63.33%
Apta_1239 DNA GGTGGATGGGGATGCTTTGTTAGTTTGTGC 63.33%
Apta_1241 DNA GGTGTGGAGTGGTGTGTGTTGTTGTTTGTC 63.33%
Apta_1247 DNA GGTGGTTGCTGTTGTTTGTGGTTGGTGTGC 63.33%
Apta_1205 DNA GGCAGGTGGTGTTGGTTGGTTGTGCGTGGAGTTGG 62.86%
Apta_1210 DNA GGGGAGGCAGTGTGTTGTGTCGTGTGTGTGCTTGG 62.86%
Apta_71 DNA GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC 61.29%
Apta_73 DNA GGGGAGTAGGTTGGTGTGGTTGGGGCTCCCC 61.29%
Apta_392 DNA GGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT 60.61%
Apta_10 DNA GGGGGGGGTGGCTGGGCGGGGTGGG 60.00%
Apta_11 DNA AGAGGGGGGGGTCGGGGTGGGTCGC 60.00%
Apta_12 DNA TGAGGGGGTGGGTGGGACGGGTTGG 60.00%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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