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Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003969
RV-23
Aliases: pep_RV23, RV-23
Normalized sequence
RIGVLLARLPKLFSLFKLMGKKV
23 amino acids
Release PepDiana-V1-20260620
31
Activity records
2
Source papers
27
Positive
4
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 26 records
PMC12024264
26 observationsAntimicrobialAntibacterialPositive observation
Record detail Table 1: RV-23 MIC 6.25 μM against K. pneumoniae ATCC 10031.
- Measure
- MIC
- Value
- 6.25 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 1: RV-23 MBC 12.5 μM against K. pneumoniae ATCC 10031.
- Measure
- MBC
- Value
- 12.5 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 1: RV-23 MIC 12.5 μM against E. coli ATCC 25992.
- Measure
- MIC
- Value
- 12.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 1: RV-23 MBC 12.5 μM against E. coli ATCC 25992.
- Measure
- MBC
- Value
- 12.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 12.5 μM against K. pneumoniae 1711.
- Measure
- MIC
- Value
- 12.5 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MBC 12.5 μM against K. pneumoniae 1711.
- Measure
- MBC
- Value
- 12.5 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 50 μM against K. pneumoniae 311.
- Measure
- MIC
- Value
- 50 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MBC 50 μM against K. pneumoniae 311.
- Measure
- MBC
- Value
- 50 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 12.5 μM against K. pneumoniae 1745.
- Measure
- MIC
- Value
- 12.5 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MBC 25 μM against K. pneumoniae 1745.
- Measure
- MBC
- Value
- 25 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 12.5 μM against K. pneumoniae 1746.
- Measure
- MIC
- Value
- 12.5 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Table 2: RV-23 MBC N/D against K. pneumoniae 1746.
- Measure
- MBC
- Value
- N/D
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 12.5 μM against E. coli 2267.
- Measure
- MIC
- Value
- 12.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MBC 12.5 μM against E. coli 2267.
- Measure
- MBC
- Value
- 12.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 25 μM against E. coli 3140.
- Measure
- MIC
- Value
- 25 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialNegative / threshold
Record detail Table 2: RV-23 MBC N/D against E. coli 3140.
- Measure
- MBC
- Value
- N/D
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 25 μM against E. coli 716.
- Measure
- MIC
- Value
- 25 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MBC 25 μM against E. coli 716.
- Measure
- MBC
- Value
- 25 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 6.25 μM against E. coli 1376.
- Measure
- MIC
- Value
- 6.25 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MBC 6.25 μM against E. coli 1376.
- Measure
- MBC
- Value
- 6.25 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MIC 6.25 μM against E. coli 1441.
- Measure
- MIC
- Value
- 6.25 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: RV-23 MBC 12.5 μM against E. coli 1441.
- Measure
- MBC
- Value
- 12.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail RV-23 causes a total reduction in biofilm attachment at 50 and 12.5 μM for K. pneumoniae and E. coli, respectively.
- Measure
- biofilm_inhibition
- Value
- 50 μM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail RV-23 causes a total reduction in biofilm attachment at 50 and 12.5 μM for K. pneumoniae and E. coli, respectively.
- Measure
- biofilm_inhibition
- Value
- 12.5 μM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail According to the best antimicrobial activity evidenced for RV-23, its combination with meropenem provides the best results, with a MIC at 3.125 μM (peptide) and 0.625 μg/mL (antibiotic) against K. pneumoniae.
- Measure
- MIC
- Value
- 3.125 μM (peptide) and 0.625 μg/mL (antibiotic)
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail According to the best antimicrobial activity evidenced for RV-23, its combination with meropenem provides the best results, with a MIC at ... 6.25 μM (peptide) and 2.5 μg/mL (antibiotic) against E. coli.
- Measure
- MIC
- Value
- 6.25 μM (peptide) and 2.5 μg/mL (antibiotic)
- Target
- Escherichia coli
- Assay
- Not reported by source
Antiviral 3 records
PMC10609114
3 observationsAntiviralGeneral AntiviralPositive observation
Record detail RV-23 was found to be more active than AR-23, with an inhibitory concentration of 50% (IC50) at 10 μM ... in co-treatment.
- Measure
- other
- Value
- 10 μM
- Target
- Vero
- Assay
- Not reported by source
AntiviralGeneral AntiviralPositive observation
Record detail RV-23 ... IC50 at ... 6.25 μM ... in virus pre-treatment assays.
- Measure
- other
- Value
- 6.25 μM
- Target
- Vero
- Assay
- Not reported by source
AntiviralGeneral AntiviralNegative / threshold
Record detail On the contrary, no activity was observed after the viral adsorption step (post-treatment), indicating that the peptides did not interfere later in the infection.
- Measure
- percent_inhibition
- Value
- no activity
- Target
- Vero
- Assay
- Not reported by source
Toxicity 2 records
PMC10609114
1 observationsToxicityCytotoxicNegative / threshold
Record detail RV-23 was not cytotoxic up to the highest dose (50 μM). Figure 1 shows cell viability at 50–3.125 μM.
- Measure
- CC50
- Value
- >50 μM
- Target
- Vero
- Assay
- Not reported by source
PMC12024264
1 observationsToxicityCytotoxicPositive observation
Record detail Hylin-a1 and RV-23 have lower toxicity with a 50% cytotoxic concentration (CC50) of 100 μM.
- Measure
- CC50
- Value
- 100 μM
- Target
- HaCaT
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003969, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00