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PEPDIA-INT-058965

Gold

RV-23

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

RIGVLLARLPKLFSLFKLMGKKV

Indexed sequence23 aa

1RIGVLLARLPKLFSLFKLMGKKV

Length

Molecular weight

2628.41 Da

Formula

C126H219N33O25S

Structure type

Linear

Synthesis

Ribosomal

Chirality

Mixed

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic13

Membrane affinity proxy

Polar1

Solubility proxy

Charged6

Net charge proxy +6

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2628.3577 Da

Molecular formula

C126H219N33O25S

Theoretical pI

Net charge at pH 7

5.7561

GRAVY

0.7478

Instability index

-3.3609

Aromaticity

0.087

Topological polar surface area

942.84 Å²

cLogP

-2.2392

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

RIGVLLARLPKLFSLFKLMGKKV

HELM 2.0

validated simple linear

PEPTIDE1{R.I.G.V.L.L.A.R.L.P.K.L.F.S.L.F.K.L.M.G.K.K.V}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(N)CCCNC(=N)N)C(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(=O)O)C(C)C)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-058965,
  title = {RV-23},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-058965},
  note = {Accessed from local PepDiana development build}
}

APA-style note

RV-23. (2026). PepDiana record PEPDIA-INT-058965. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-058965

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (41 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P058965_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP01264apd / linked
CTPDB_P058965_ACT_apd_0001	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	AP01264apd / linked
CTPDB_P058965_ACT_apd_0002	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP01264apd / linked
CTPDB_P058965_ACT_apd_0004	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP01264apd / linked
CTPDB_P058965_ACT_camp_0008	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10870camp / linked
CTPDB_P058965_ACT_camp_0009	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10870camp / linked
CTPDB_P058965_ACT_camp_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3139camp / linked
CTPDB_P058965_ACT_camp_0006	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3139camp / linked
CTPDB_P058965_ACT_camp_0007	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ3139camp / linked
CTPDB_P058965_ACT_dbaasp_0010	Antimicrobial	-	2.5 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0011	Antimicrobial	-	40 µM	Staphylococcus aureus NCTC 8325	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0012	Antimicrobial	-	80 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0013	Antimicrobial	-	12.5 µM	Klebsiella pneumoniae KK3 9904	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0014	Antimicrobial	-	6 µM	Enterobacter cloacae HNTCC 53001	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0015	Antimicrobial	-	6 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0016	Antimicrobial	-	25 µM	Salmonella enterica subsp. enterica serovar Typhimurium LT2	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0017	Antimicrobial	-	>100 µM	Proteus mirabilis ATCC 25933	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0018	Antimicrobial	-	6 µM	Staphylococcus epidermidis RP62A	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0019	Antimicrobial	-	12.5 µM	Enterococcus faecalis ATCC 29212	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0020	Antimicrobial	-	12.5 µM	Streptococcus group B HNTCC 80130	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0021	Antimicrobial	-	20 µM	Staphylococcus aureus T7/5	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0022	Antimicrobial	-	10 µM	Staphylococcus aureus T17/13	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0023	Antimicrobial	-	>50 µM	Bacteroides fragilis ATCC 25285	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0024	Antimicrobial	-	>50 µM	Bacteroides fragilis	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0025	Antimicrobial	-	6 µM	Prevotella melaninogenica	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0026	Antimicrobial	-	50 µM	Fusobacterium varium ATCC 27725	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0027	Antimicrobial	-	>50 µM	Fusobacterium nucleatum	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0028	Antimicrobial	-	12.5 µM	Clostridium tertium ATCC 19465	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0029	Antimicrobial	-	12.5 µM	Clostridium perfringens ATCC 10543	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0030	Antimicrobial	-	50 µM	Clostridium septicum	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0031	Antimicrobial	-	12.5 µM	Cutibacterium acnes ATCC 11828	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0032	Antimicrobial	-	6 µM	Cutibacterium acnes	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0033	Antimicrobial	-	50 µM	Peptoniphilus asaccharolyticus ATCC 29743	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dbaasp_0034	Antimicrobial	-	25 µM	Peptostreptococcus anaerobius	Not reported by source	DBAASPS_4189_chain0dbaasp / linked
CTPDB_P058965_ACT_dramp_0035	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP01826dramp / linked
CTPDB_P058965_ACT_dramp_0036	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP01826dramp / linked
CTPDB_P058965_ACT_dramp_0037	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP01826dramp / linked
CTPDB_P058965_ACT_dramp_0038	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP01826dramp / linked
CTPDB_P058965_ACT_satpdb_0039	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb27141satpdb / linked
CTPDB_P058965_ACT_satpdb_0040	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb27141satpdb / linked
CTPDB_P058965_ACT_satpdb_0041	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb27141satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003969 View all experimental records

Provenance

Source database records (6)

apd

AP01264

Raw sequence

RIGVLLARLPKLFSLFKLMGKKV

camp

CAMPSQ3139

Raw sequence

RIGVLLARLPKLFSLFKLMGKKV

camp

CAMPSQ10870

Raw sequence

RIGVLLARLPKLFSLFKLMGKKV

dbaasp

DBAASPS_4189_chain0

Raw sequence

RIGVLLARLPKLFSLFKLMGKKV

dramp

DRAMP01826

Raw sequence

RIGVLLARLPKLFSLFKLMGKKV

satpdb

satpdb27141

Raw sequence

RIGVLLARLPKLFSLFKLMGKKV

Citation trail

Literature (5 records)

{"reference": "Peptides. 2006 Jun;27(6):1305-12", "title": "Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species.", "author": "Conlon JM, Al-Ghafari N, Coquet L, Leprince J, Jouenne T, Vaudry H, Davidson C.2006"}

{"reference": "Peptides. 2006 Jun;27(6):1305-12", "title": "Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species.", "author": "Conlon JM, Al-Ghafari N, Coquet L, Leprince J, Jouenne T, Vaudry H, Davidson C.2006"}

-

--PMID 16307827

-

--PMID 26975766

Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species.

Conlon JM, Al-Ghafari N, Coquet L, Leprince J, Jouenne T, Vaudry H, Davidson C

Peptides2006PMID 17196372

Evidence from peptidomic analysis of skin secretions that the red-legged frogs, Rana aurora draytonii and Rana aurora aurora, are distinct species.##Design of an α-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity

Conlon JM, Al-Ghafari N, Coquet L, Leprince J, Jouenne T, Vaudry H, Davidson C.##Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji

Peptides2006PMID 27271216

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.491115+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "35",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.27271216] 60% hemolysis at 20 μM , 90% hemolysis at 40 μM , 100% hemolysis at 60 μM , 100% hemolysis at 100 μM against human red blood cells",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCCCCTTTSHHHHTTTTTTTTTC"
}