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Paper-scoped peptide mentionSequence reported

pep_RV23

PMC10609114::PEP000001

Source publication

Melittin-Related Peptides Interfere with Sandfly Fever Naples Virus Infection by Interacting with Heparan Sulphate

Microorganisms · 2023

DOI 10.3390/microorganisms11102446 PMC10609114 PMID 37894104

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 4

Sequence evidence

Reported molecular identity

RIGVLLARLPKLFSLFKLMGKKV

RIGVLLARLPKLFSLFKLMGKKV

Resolved peptide links

PEPDIA-PLP-003969 CTPDB_P058965

Experimental observations

Records linked to this mention

ToxicityCytotoxicNegative / threshold

RV-23 was not cytotoxic up to the highest dose (50 μM). Figure 1 shows cell viability at 50–3.125 μM.

Mention PMC10609114::PEP000001PMC10609114text

Measure: CC50
Value: >50 μM
Target: Vero
Assay: Not reported by source

Source publication

AntiviralGeneral AntiviralPositive observation

RV-23 was found to be more active than AR-23, with an inhibitory concentration of 50% (IC50) at 10 μM ... in co-treatment.

Mention PMC10609114::PEP000001PMC10609114text

Measure: other
Value: 10 μM
Target: Vero
Assay: Not reported by source

Source publication

AntiviralGeneral AntiviralPositive observation

RV-23 ... IC50 at ... 6.25 μM ... in virus pre-treatment assays.

Mention PMC10609114::PEP000001PMC10609114text

Measure: other
Value: 6.25 μM
Target: Vero
Assay: Not reported by source

Source publication

AntiviralGeneral AntiviralNegative / threshold

On the contrary, no activity was observed after the viral adsorption step (post-treatment), indicating that the peptides did not interfere later in the infection.

Mention PMC10609114::PEP000001PMC10609114text

Measure: percent_inhibition
Value: no activity
Target: Vero
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.