PepDiana
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Primary experimental recordPositive observation

PMC12024264::ACT015978

AR-23

Evidence text

Paper-level observation

AR23, which works worse than RV-23 when used alone, when combined with the antibiotic, gives similar if not better results than RV-23, indeed, with calculated MIC values at 3.125 μM (peptide) and 0.625 μg/mL (antibiotic) against K. pneumoniae.
textConfidence: medium

Assay observation

Activity
Antimicrobial
Subtype
Antibacterial
Measure
MIC
Comparator
=
Raw observation
3.125 μM (peptide) and 0.625 μg/mL (antibiotic)
Normalized measurement
=3.125 µM
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Klebsiella pneumoniae
Assay method
Not reported by source
Sequence
AIGSILGALAKGLPTLISWIKNR
Standardization
ready simple

Source publication

Frog Skin Peptides Hylin-a1, AR-23, and RV-23: Promising Tools Against Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae Infections

Antibiotics · 2025

DOI 10.3390/antibiotics14040374 PMC12024264
Parent mention Integrated peptide

Related peptide identities

PEPDIA-PLP-003381PEPDIA-INT-014813

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.