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PEPDIA-INT-014813

Gold

Prepromelittin-related peptide, MRP, AR-23

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

AIGSILGALAKGLPTLISWIKNR

Indexed sequence23 aa

1AIGSILGALAKGLPTLISWIKNR

Length

Molecular weight

2392.92 Da

Formula

C111H190N30O28

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic12

Membrane affinity proxy

Polar4

Solubility proxy

Charged3

Net charge proxy +3

Aromatic1

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

2392.8802 Da

Molecular formula

C111H190N30O28

Theoretical pI

11.1664

Net charge at pH 7

2.7939

GRAVY

0.7304

Instability index

15.2391

Aromaticity

0.0435

Topological polar surface area

928.24 Å²

cLogP

-6.6211

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

AIGSILGALAKGLPTLISWIKNR

HELM 2.0

validated simple linear

PEPTIDE1{A.I.G.S.I.L.G.A.L.A.K.G.L.P.T.L.I.S.W.I.K.N.R}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(C)N)C(=O)NCC(=O)NC(CO)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CO)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)O)C(C)CC)C(C)CC)C(C)O)C(C)CC

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](C)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-014813,
  title = {Prepromelittin-related peptide, MRP, AR-23},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-014813},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Prepromelittin-related peptide, MRP, AR-23. (2026). PepDiana record PEPDIA-INT-014813. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-014813

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (69 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P014813_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP00694apd / linked
CTPDB_P014813_ACT_apd_0001	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	AP00694apd / linked
CTPDB_P014813_ACT_apd_0002	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP00694apd / linked
CTPDB_P014813_ACT_apd_0004	Enzyme Inhibitor	General Enzyme Inhibitor	Not available in the current structured import	Unknown	Not reported by source	AP00694apd / linked
CTPDB_P014813_ACT_apd_0005	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP00694apd / linked
CTPDB_P014813_ACT_camp_0006	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ156camp / linked
CTPDB_P014813_ACT_camp_0007	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ156camp / linked
CTPDB_P014813_ACT_camp_0008	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ156camp / linked
CTPDB_P014813_ACT_camp_0009	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ156camp / linked
CTPDB_P014813_ACT_camp_0010	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ156camp / linked
CTPDB_P014813_ACT_cancerppd_0011	Anticancer	Anticancer	Not available in the current structured import	Unknown	Not Available	4433cancerppd / linked
CTPDB_P014813_ACT_dbaasp_0012	Antimicrobial	-	3.5 µM	Staphylococcus aureus NCTC 8325	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0013	Antimicrobial	-	20 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0014	Antimicrobial	-	19 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0015	Antimicrobial	-	NA	Human rhinovirus 2 (HRV2)	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0016	Antimicrobial	-	14 µM	Mouse T-lymphoma cells EL4	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0017	Antimicrobial	-	12.5 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0018	Antimicrobial	-	50 µM	Klebsiella pneumoniae KK3 9904	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0019	Antimicrobial	-	12.5 µM	Enterobacter cloacae HNTCC 53001	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0020	Antimicrobial	-	25 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0021	Antimicrobial	-	50 µM	Salmonella enterica subsp. enterica serovar Typhimurium LT2	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0022	Antimicrobial	-	>100 µM	Proteus mirabilis ATCC 25933	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0023	Antimicrobial	-	6 µM	Staphylococcus aureus NCTC 8325	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0024	Antimicrobial	-	3 µM	Staphylococcus epidermidis RP62A	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0025	Antimicrobial	-	6 µM	Enterococcus faecalis ATCC 29212	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0026	Antimicrobial	-	12.5 µM	Streptococcus group B HNTCC 80130	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0027	Antimicrobial	-	12.5 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0028	Antimicrobial	-	2.5 µM	Staphylococcus aureus T7/5	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0029	Antimicrobial	-	5 µM	Staphylococcus aureus T27/9	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0030	Antimicrobial	-	20 µM	Staphylococcus aureus T58/7	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0031	Antimicrobial	-	>50 µM	Bacteroides fragilis ATCC 25285	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0032	Antimicrobial	-	>50 µM	Bacteroides fragilis	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0033	Antimicrobial	-	3 µM	Prevotella melaninogenica	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0034	Antimicrobial	-	50 µM	Fusobacterium varium ATCC 27725	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0035	Antimicrobial	-	>50 µM	Fusobacterium nucleatum	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0036	Antimicrobial	-	12.5 µM	Clostridium tertium ATCC 19465	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0037	Antimicrobial	-	>50 µM	Clostridium perfringens ATCC 10543	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0038	Antimicrobial	-	12.5 µM	Clostridium septicum	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0039	Antimicrobial	-	12.5 µM	Cutibacterium acnes ATCC 11828	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0040	Antimicrobial	-	25 µM	Cutibacterium acnes	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0041	Antimicrobial	-	50 µM	Peptoniphilus asaccharolyticus ATCC 29743	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0042	Antimicrobial	-	25 µM	Peptostreptococcus anaerobius	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0043	Antimicrobial	-	25 µM	Escherichia coli CGMCC 1.8732	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0044	Antimicrobial	-	12.5 µM	Pseudomonas aeruginosa CGMCC 1.2421	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0045	Antimicrobial	-	12.5 µM	Klebsiella pneumoniae CGMCC 1.1736	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0046	Antimicrobial	-	6.25 µM	Staphylococcus aureus CGMCC 1.8721	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0047	Antimicrobial	-	3.13 µM	Staphylococcus epidermidis CGMCC 1.4260	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0048	Antimicrobial	-	3.13 µM	Bacillus subtilis CGMCC 1.3376	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0049	Antimicrobial	-	25 µM	Batrachochytrium dendrobatidis	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0050	Antimicrobial	-	12.5 µM	Acinetobacter baumannii	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0051	Antimicrobial	-	0.39 µM	HSV-1	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0052	Antimicrobial	-	3.125 µM	Mink enteritis virus (MeV)	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0053	Antimicrobial	-	3.125 µM	Human parainfluenza Virus 2 ( HPIV2)	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0054	Antimicrobial	-	3.125 µM	HCoV-229E	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0055	Antimicrobial	-	12.5 µM	SARS-CoV-2	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dbaasp_0056	Antimicrobial	-	3.12 µM	HSV-1	Not reported by source	DBAASPS_2156_chain0dbaasp / linked
CTPDB_P014813_ACT_dramp_0057	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP01347dramp / linked
CTPDB_P014813_ACT_dramp_0058	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP01347dramp / linked
CTPDB_P014813_ACT_dramp_0059	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP01347dramp / linked
CTPDB_P014813_ACT_dramp_0060	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP01347dramp / linked
CTPDB_P014813_ACT_dramp_0061	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP01347dramp / linked
CTPDB_P014813_ACT_satpdb_0062	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	satpdb11811satpdb / linked
CTPDB_P014813_ACT_satpdb_0063	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb11811satpdb / linked
CTPDB_P014813_ACT_satpdb_0064	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb11811satpdb / linked
CTPDB_P014813_ACT_satpdb_0065	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb11811satpdb / linked
CTPDB_P014813_ACT_satpdb_0066	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb14614satpdb / linked
CTPDB_P014813_ACT_satpdb_0067	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb14614satpdb / linked
CTPDB_P014813_ACT_satpdb_0068	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb14614satpdb / linked
CTPDB_P014813_ACT_satpdb_0069	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb14614satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003381 View all experimental records

Provenance

Source database records (7)

apd

AP00694

Raw sequence

AIGSILGALAKGLPTLISWIKNR

camp

CAMPSQ156

Raw sequence

AIGSILGALAKGLPTLISWIKNR

cancerppd

4433

Raw sequence

AIGSILGALAKGLPTLISWIKNR

dbaasp

DBAASPS_2156_chain0

Raw sequence

AIGSILGALAKGLPTLISWIKNR

dramp

DRAMP01347

Raw sequence

AIGSILGALAKGLPTLISWIKNR

satpdb

satpdb11811

Raw sequence

AIGSILGALAKGLPTLISWIKNR

satpdb

satpdb14614

Raw sequence

AIGSILGALAKGLPTLISWIKNR

Citation trail

Literature (6 records)

A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties

Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pál T.2003

Biochem Biophys Res Commun2003PMID 12804591

-

--PMID 35055066

A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties

Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pál T

Biochem Biophys Res Commun2003PMID 17196372

A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties

Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pál T

Biochem Biophys Res Commun2003PMID 27271216

A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties

Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pál T

Biochem Biophys Res Commun2003PMID 15784290

A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties##Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii##Design of an α-helical antimicrobial peptide with improved cell selective and potent anti-biofilm activity

Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pál T##Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.##Shi-KunZhang, Jin-wen Song, FengGong, Su-Bo Li, Hong-Yu Chang, Hui-MinXie, Hong-WeiGao, Ying-XiaTan & Shou-Ping Ji

Biochem Biophys Res Commun2003PMID 17174009

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.203743+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "8",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "20",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Mouse fibroblasts L929"
    },
    {
      "unit": "µM",
      "value": "3.13",
      "source_db": "dbaasp",
      "assay_method": "10% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.27271216] 100% hemolysis at 20 μM against human red blood cells",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.12804591]Display cytotoxic against L929 fibroblasts(LC50=20 μM);EL4 T-lymphoma cells(LC50=14 μM).##[Ref.27271216]L929 cells:Cell viability is approximately 10% at the concentration of 6.25 μM.",
      "toxicity_type": "Cytotoxic"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "pdb_id": "6dst resolved by NMR (related PDB_ID)",
  "source_db": "dramp"
}