AntimicrobialAntibacterialPositive observation
Record detail Table 2: S. aureus ATCC-29215 MIC 15 µM.
- Measure
- MIC
- Value
- 15 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
Source publication
HAZ, a novel peptide with broad-spectrum antibacterial activity
Saudi Pharmaceutical Journal · 2022
- Sequence status
- reported
- Standardization
- Sequence ready
- Source location
- unknown
- Activity records
- 36
Sequence evidence
Reported molecular identity
GVKFAKRFWRFAKKAFKRFEK
HAZ peptide (NH2-GVKFAKRFWRFAKKAFKR-FEK-COOH) was supplied by GL Biochem (Shanghai, China).
Resolved peptide links
Experimental observations
Records linked to this mention
AntimicrobialAntibacterialPositive observation
Record detail Table 2: S. aureus ATCC-29215 MBC 15 µM.
- Measure
- MBC
- Value
- 15 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: E. coli ATCC-25922 MIC 20 µM.
- Measure
- MIC
- Value
- 20 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: E. coli ATCC-25922 MBC 20 µM.
- Measure
- MBC
- Value
- 20 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: S. aureus ATCC-BAA-41 MIC 20 µM.
- Measure
- MIC
- Value
- 20 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: S. aureus ATCC-BAA-41 MBC 20 µM.
- Measure
- MBC
- Value
- 20 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: E. coli ATCC-BAA-2452 MIC 20 µM.
- Measure
- MIC
- Value
- 20 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 2: E. coli ATCC-BAA-2452 MBC 20 µM.
- Measure
- MBC
- Value
- 20 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Table 3: S. aureus (ATCC BAA41) MBEC 30 µM.
- Measure
- other
- Value
- 30 (MBEC)
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Table 3: S. aureus (ATCC 29215) MBEC 30 µM.
- Measure
- other
- Value
- 30 (MBEC)
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Table 3: E. coli (ATCC BAA-2452) MBEC 40 µM.
- Measure
- other
- Value
- 40 (MBEC)
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAnti-BiofilmPositive observation
Record detail Table 3: E. coli (ATCC 25922) MBEC 40 µM.
- Measure
- other
- Value
- 40 (MBEC)
- Target
- Escherichia coli
- Assay
- Not reported by source
ToxicityHemolyticPositive observation
Record detail Section 3.4: HAZ peptide displayed minimal hemolytic toxicity on RBCs even at concentrations higher than therapeutic ones. Hemolytic reaction was only detected at peptide concentrations beyond 20 µM, and a hemolysis percentage around 20 % and beyond was detected at concentrations higher than 120 µM.
- Measure
- hemolysis
- Value
- minimal hemolytic toxicity ... Hemolytic reaction was only detected at peptide concentrations beyond 20 µM, and a hemolysis percentage around 20 % and beyond was detected at concentrations higher than 120 µM
- Target
- Homo sapiens
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail Section 3.5: HAZ displayed potent antiproliferative effects on A549 cells, with an IC50 around 5.44 µM.
- Measure
- other
- Value
- 5.44 µM
- Target
- Homo sapiens
- Assay
- Not reported by source
AnticancerCytotoxicPositive observation
Record detail Section 3.5: Even 1 µM was sufficient to inhibit cell proliferation by around 20 %.
- Measure
- cell_viability
- Value
- Even 1 µM was sufficient to inhibit cell proliferation by around 20 %
- Target
- Homo sapiens
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Section 3.5: more than 95 % viability inhibition achieved by treatment with 10 µM.
- Measure
- cell_viability
- Value
- more than 95 % viability inhibition achieved by treatment with 10 µM
- Target
- Homo sapiens
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli 25922, HAZ MIC in combination with LVX = 2.5 µM.
- Measure
- MIC
- Value
- 2.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli 25922, HAZ MIC in combination with CHL = 0.3125 µM.
- Measure
- MIC
- Value
- 0.3125 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli 25922, HAZ MIC in combination with RIF = 2.5 µM.
- Measure
- MIC
- Value
- 2.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli 25922, HAZ MIC in combination with AMP = 5 µM.
- Measure
- MIC
- Value
- 5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli 25922, HAZ MIC in combination with DOX = 2.5 µM.
- Measure
- MIC
- Value
- 2.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli BAA-2452, HAZ MIC in combination with LVX = 0.625 µM.
- Measure
- MIC
- Value
- 0.625 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli BAA-2452, HAZ MIC in combination with CHL = 0.375 µM.
- Measure
- MIC
- Value
- 0.375 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli BAA-2452, HAZ MIC in combination with RIF = 17.5 µM.
- Measure
- MIC
- Value
- 17.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli BAA-2452, HAZ MIC in combination with AMP = 0.625 µM.
- Measure
- MIC
- Value
- 0.625 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: E. coli BAA-2452, HAZ MIC in combination with DOX = 2.5 µM.
- Measure
- MIC
- Value
- 2.5 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus 29215, HAZ MIC in combination with LVX = 0.625 µM.
- Measure
- MIC
- Value
- 0.625 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus 29215, HAZ MIC in combination with CHL = 0.3125 µM.
- Measure
- MIC
- Value
- 0.3125 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus 29215, HAZ MIC in combination with RIF = 5.0 µM.
- Measure
- MIC
- Value
- 5.0 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus 29215, HAZ MIC in combination with AMP = 2.5 µM.
- Measure
- MIC
- Value
- 2.5 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus 29215, HAZ MIC in combination with DOX = 2.5 µM.
- Measure
- MIC
- Value
- 2.5 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus BAA-41, HAZ MIC in combination with LVX = 5 µM.
- Measure
- MIC
- Value
- 5 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus BAA-41, HAZ MIC in combination with CHL = 0.375 µM.
- Measure
- MIC
- Value
- 0.375 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus BAA-41, HAZ MIC in combination with RIF = 2.5 µM.
- Measure
- MIC
- Value
- 2.5 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus BAA-41, HAZ MIC in combination with AMP = 0.3125 µM.
- Measure
- MIC
- Value
- 0.3125 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
AntimicrobialAntibacterialPositive observation
Record detail Table 4: S. aureus BAA-41, HAZ MIC in combination with DOX = 1.25 µM.
- Measure
- MIC
- Value
- 1.25 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.