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Paper-scoped peptide mentionSequence reported

PCR12mod6

PMC12444544::PEP000002

Source publication

Rational Design of PCR12mod6, a Cathelicidin-HR-Derived Peptide with Enhanced Dual-Action Antimicrobial and Antioxidant Activity

ACS Omega · 2025

DOI 10.1021/acsomega.5c03658 PMC12444544 PMID 40978391

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 25

Sequence evidence

Reported molecular identity

PCRKIFCRWKKR

PCRKIFCRWKKR

Resolved peptide links

PEPDIA-PLP-002177

Experimental observations

Records linked to this mention

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 50 μg/mL against Bacillus megaterium TISTR067.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 50 µg/mL
Target: Bacillus megaterium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Bacillus subtilis TISTR1248.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Bacillus subtilis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Bacillus cereus TISTR1449.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Bacillus cereus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Enterococcus faecalis TISTR927.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12mod6 MIC >400 μg/mL against Staphylococcus aureus ATCC25923.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12mod6 MIC >400 μg/mL against Aeromonas hydrophila ATCC7966.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Aeromonas hydrophila
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Edwardsiella tarda DMST38217.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Edwardsiella tarda
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12mod6 MIC >400 μg/mL against Salmonella derby DMST16881.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Salmonella derby
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Salmonella typhimurium TISTR1472.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Salmonella typhimurium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12mod6 growth inhibition against Bacillus subtilis 14.05%.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 14.05%
Target: Bacillus subtilis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12mod6 growth inhibition against Bacillus cereus 29.08%.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 29.08%
Target: Bacillus cereus
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12mod6 ABTS scavenging 7.91% at 25 μg/mL.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 7.91%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12mod6 ABTS scavenging 98.95% at 400 μg/mL.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 98.95%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5B: PCR12mod6 DPPH scavenging 3.85% at 25 μg/mL.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 3.85%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5B: PCR12mod6 DPPH scavenging 52.96% at 400 μg/mL.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 52.96%
Target: Not reported by source
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12mod6 cell viability 107.86% at 15.625 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 107.86%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12mod6 cell viability 103.09% at 500 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 103.09%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12mod6 cell viability 95.14% at 1000 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 95.14%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6B: PCR12mod6 cell viability 42.61% at 250 μg/mL under H2O2 stress.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 42.61%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6B: PCR12mod6 cell viability 78.80% at 500 μg/mL under H2O2 stress.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 78.80%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

Figure 7A: PCR12mod6 reduced NO production to 69.11% of control at 250 μg/mL in LPS-stimulated RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 69.11% of control
Target: RAW 264.7
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

Figure 7A: PCR12mod6 reduced NO production to 41.66% of control at 500 μg/mL in LPS-stimulated RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 41.66% of control
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 7B: PCR12mod6 cell viability 81.67% at 500 μg/mL in LPS-treated RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 81.67%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Figure 9: PCR12mod6 hemolysis 19.39% at 25 μg/mL against sheep red blood cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: hemolysis
Value: 19.39%
Target: Ovis aries
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Figure 9: PCR12mod6 hemolysis 15.95% at 400 μg/mL against sheep red blood cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: hemolysis
Value: 15.95%
Target: Ovis aries
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.