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Primary-literature peptidehigh evidence

PEPDIA-PLP-002177

PCR12mod6

Aliases: PCR12mod6

Normalized sequence

PCRKIFCRWKKR

12 amino acids

Release PepDiana-V1-20260620

25

Activity records

1

Source papers

22

Positive

3

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

1621.0316 Da

Molecular formula

C73H121N25O13S2

Theoretical pI

11.0186

Net charge at pH 7

5.9357

GRAVY

-1.2833

Instability index

70.7083

Aromaticity

0.1667

Topological polar surface area

648.98 Å²

cLogP

-3.795

Hydrogen-bond donors

28

Hydrogen-bond acceptors

21

Rotatable bonds

55

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

PCRKIFCRWKKR

HELM 2.0

validated simple linear

PEPTIDE1{P.C.R.K.I.F.C.R.W.K.K.R}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CS)NC(=O)C1CCCN1)C(=O)NC(Cc1ccccc1)C(=O)NC(CS)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

Paper-level observations

Experimental evidence grouped by activity

Antimicrobial 11 records

PMC12444544

11 observations

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 50 μg/mL against Bacillus megaterium TISTR067.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 50 µg/mL
Target: Bacillus megaterium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Bacillus subtilis TISTR1248.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Bacillus subtilis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Bacillus cereus TISTR1449.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Bacillus cereus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Enterococcus faecalis TISTR927.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12mod6 MIC >400 μg/mL against Staphylococcus aureus ATCC25923.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12mod6 MIC >400 μg/mL against Aeromonas hydrophila ATCC7966.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Aeromonas hydrophila
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Edwardsiella tarda DMST38217.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Edwardsiella tarda
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12mod6 MIC >400 μg/mL against Salmonella derby DMST16881.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Salmonella derby
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: PCR12mod6 MIC 25 μg/mL against Salmonella typhimurium TISTR1472.

Mention PMC12444544::PEP000002PMC12444544table

Measure: MIC
Value: 25 µg/mL
Target: Salmonella typhimurium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12mod6 growth inhibition against Bacillus subtilis 14.05%.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 14.05%
Target: Bacillus subtilis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12mod6 growth inhibition against Bacillus cereus 29.08%.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 29.08%
Target: Bacillus cereus
Assay: Not reported by source

Source publication

Toxicity 8 records

PMC12444544

8 observations

ToxicityCytotoxicPositive observation

Figure 6A: PCR12mod6 cell viability 107.86% at 15.625 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 107.86%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12mod6 cell viability 103.09% at 500 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 103.09%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12mod6 cell viability 95.14% at 1000 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 95.14%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6B: PCR12mod6 cell viability 42.61% at 250 μg/mL under H2O2 stress.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 42.61%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6B: PCR12mod6 cell viability 78.80% at 500 μg/mL under H2O2 stress.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 78.80%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 7B: PCR12mod6 cell viability 81.67% at 500 μg/mL in LPS-treated RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: cell_viability
Value: 81.67%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Figure 9: PCR12mod6 hemolysis 19.39% at 25 μg/mL against sheep red blood cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: hemolysis
Value: 19.39%
Target: Ovis aries
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Figure 9: PCR12mod6 hemolysis 15.95% at 400 μg/mL against sheep red blood cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: hemolysis
Value: 15.95%
Target: Ovis aries
Assay: Not reported by source

Source publication

Antioxidant 4 records

PMC12444544

4 observations

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12mod6 ABTS scavenging 7.91% at 25 μg/mL.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 7.91%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12mod6 ABTS scavenging 98.95% at 400 μg/mL.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 98.95%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5B: PCR12mod6 DPPH scavenging 3.85% at 25 μg/mL.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 3.85%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5B: PCR12mod6 DPPH scavenging 52.96% at 400 μg/mL.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 52.96%
Target: Not reported by source
Assay: Not reported by source

Source publication

Immunomodulatory 2 records

PMC12444544

2 observations

ImmunomodulatoryAnti-inflammatoryPositive observation

Figure 7A: PCR12mod6 reduced NO production to 69.11% of control at 250 μg/mL in LPS-stimulated RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 69.11% of control
Target: RAW 264.7
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

Figure 7A: PCR12mod6 reduced NO production to 41.66% of control at 500 μg/mL in LPS-stimulated RAW 264.7 cells.

Mention PMC12444544::PEP000002PMC12444544figure

Measure: percent_inhibition
Value: 41.66% of control
Target: RAW 264.7
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-002177, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00