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Paper-scoped peptide mentionSequence reported

PCR12

PMC12444544::PEP000001

Source publication

Rational Design of PCR12mod6, a Cathelicidin-HR-Derived Peptide with Enhanced Dual-Action Antimicrobial and Antioxidant Activity

ACS Omega · 2025

DOI 10.1021/acsomega.5c03658 PMC12444544 PMID 40978391

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 25

Sequence evidence

Reported molecular identity

PCRGIFCRTGSR

PCRGIFCRTGSR

Resolved peptide links

PEPDIA-PLP-002176

Experimental observations

Records linked to this mention

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Bacillus megaterium TISTR067.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Bacillus megaterium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Bacillus subtilis TISTR1248.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Bacillus subtilis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Bacillus cereus TISTR1449.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Bacillus cereus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Enterococcus faecalis TISTR927.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Staphylococcus aureus ATCC25923.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Aeromonas hydrophila ATCC7966.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Aeromonas hydrophila
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Edwardsiella tarda DMST38217.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Edwardsiella tarda
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Salmonella derby DMST16881.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Salmonella derby
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Salmonella typhimurium TISTR1472.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Salmonella typhimurium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12 growth inhibition against Bacillus megaterium 64.60%.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 64.60%
Target: Bacillus megaterium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12 growth inhibition against Aeromonas hydrophila 82.36%.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 82.36%
Target: Aeromonas hydrophila
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12 growth inhibition against Salmonella derby 94.35%.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 94.35%
Target: Salmonella derby
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12 ABTS scavenging 7.91% at 25 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 7.91%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12 ABTS scavenging 17.18% at 200 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 17.18%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12 ABTS scavenging 74.88% at 400 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 74.88%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5B: PCR12 DPPH scavenging 1.13% at 25 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 1.13%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5B: PCR12 DPPH scavenging 27.70% at 400 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 27.70%
Target: Not reported by source
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12 cell viability 106.86% at 15.625 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 106.86%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12 cell viability 90.77% at 500 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 90.77%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12 cell viability 22.39% at 1000 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 22.39%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6B: PCR12 cell viability 42.09% at 250 μg/mL under H2O2 stress.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 42.09%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6B: PCR12 cell viability 65.66% at 500 μg/mL under H2O2 stress.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 65.66%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

Figure 7A: PCR12 reduced NO production to 90.54% of control at 250 μg/mL in LPS-stimulated RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 90.54% of control
Target: RAW 264.7
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

Figure 7A: PCR12 reduced NO production to 74.25% of control at 500 μg/mL in LPS-stimulated RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 74.25% of control
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 7B: PCR12 cell viability 71.30% at 500 μg/mL in LPS-treated RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 71.30%
Target: RAW 264.7
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.