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Primary-literature peptidehigh evidence

PEPDIA-PLP-002176

PCR12

Aliases: PCR12

Normalized sequence

PCRGIFCRTGSR

12 amino acids

Release PepDiana-V1-20260620

25

Activity records

1

Source papers

16

Positive

9

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

1352.5886 Da

Molecular formula

C55H93N21O15S2

Theoretical pI

10.4341

Net charge at pH 7

2.9387

GRAVY

-0.425

Instability index

-2.2917

Aromaticity

0.0833

Topological polar surface area

595.59 Å²

cLogP

-8.2701

Hydrogen-bond donors

26

Hydrogen-bond acceptors

20

Rotatable bonds

43

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

PCRGIFCRTGSR

HELM 2.0

validated simple linear

PEPTIDE1{P.C.R.G.I.F.C.R.T.G.S.R}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C(CS)NC(=O)C1CCCN1)C(=O)NC(Cc1ccccc1)C(=O)NC(CS)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NCC(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)O)C(C)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O

Paper-level observations

Experimental evidence grouped by activity

Antimicrobial 12 records

PMC12444544

12 observations

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Bacillus megaterium TISTR067.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Bacillus megaterium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Bacillus subtilis TISTR1248.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Bacillus subtilis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Bacillus cereus TISTR1449.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Bacillus cereus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Enterococcus faecalis TISTR927.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Staphylococcus aureus ATCC25923.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Aeromonas hydrophila ATCC7966.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Aeromonas hydrophila
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Edwardsiella tarda DMST38217.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Edwardsiella tarda
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Salmonella derby DMST16881.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Salmonella derby
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialNegative / threshold

Table 3: PCR12 MIC >400 μg/mL against Salmonella typhimurium TISTR1472.

Mention PMC12444544::PEP000001PMC12444544table

Measure: MIC
Value: >400 µg/mL
Target: Salmonella typhimurium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12 growth inhibition against Bacillus megaterium 64.60%.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 64.60%
Target: Bacillus megaterium
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12 growth inhibition against Aeromonas hydrophila 82.36%.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 82.36%
Target: Aeromonas hydrophila
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Figure 4: PCR12 growth inhibition against Salmonella derby 94.35%.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 94.35%
Target: Salmonella derby
Assay: Not reported by source

Source publication

Toxicity 6 records

PMC12444544

6 observations

ToxicityCytotoxicPositive observation

Figure 6A: PCR12 cell viability 106.86% at 15.625 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 106.86%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12 cell viability 90.77% at 500 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 90.77%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6A: PCR12 cell viability 22.39% at 1000 μg/mL in RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 22.39%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6B: PCR12 cell viability 42.09% at 250 μg/mL under H2O2 stress.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 42.09%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 6B: PCR12 cell viability 65.66% at 500 μg/mL under H2O2 stress.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 65.66%
Target: RAW 264.7
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Figure 7B: PCR12 cell viability 71.30% at 500 μg/mL in LPS-treated RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: cell_viability
Value: 71.30%
Target: RAW 264.7
Assay: Not reported by source

Source publication

Antioxidant 5 records

PMC12444544

5 observations

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12 ABTS scavenging 7.91% at 25 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 7.91%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12 ABTS scavenging 17.18% at 200 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 17.18%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5A: PCR12 ABTS scavenging 74.88% at 400 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 74.88%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5B: PCR12 DPPH scavenging 1.13% at 25 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 1.13%
Target: Not reported by source
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

Figure 5B: PCR12 DPPH scavenging 27.70% at 400 μg/mL.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 27.70%
Target: Not reported by source
Assay: Not reported by source

Source publication

Immunomodulatory 2 records

PMC12444544

2 observations

ImmunomodulatoryAnti-inflammatoryPositive observation

Figure 7A: PCR12 reduced NO production to 90.54% of control at 250 μg/mL in LPS-stimulated RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 90.54% of control
Target: RAW 264.7
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

Figure 7A: PCR12 reduced NO production to 74.25% of control at 500 μg/mL in LPS-stimulated RAW 264.7 cells.

Mention PMC12444544::PEP000001PMC12444544figure

Measure: percent_inhibition
Value: 74.25% of control
Target: RAW 264.7
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-002176, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00