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Paper-scoped peptide mentionSequence reported

Ang I

PMC12296148::PEP000001

Source publication

Aminopeptidase A Effect on Angiotensin Peptides and Their Blood Pressure Action

International Journal of Molecular Sciences · 2025

DOI 10.3390/ijms26146990PMC12296148PMID 40725237
Sequence status
reported
Standardization
Sequence ready
Source location
text
Activity records
2

Sequence evidence

Reported molecular identity

DRVYIHPFHL

Ang I (1-10) is described as a decapeptide with N-terminal aspartate; sequence inferred from standard RAS nomenclature used in the paper.

Resolved peptide links

PEPDIA-PLP-003454CTPDB_P080721

Experimental observations

Records linked to this mention

Metabolic/CardiovascularOtherPositive observation
Record detail

In the in vitro assay, the murine rAPA (mrAPA) showed a substantial cleavage of aspartate from Ang I (17,735 ± 4316 RFU, N= 4).

Mention PMC12296148::PEP000001PMC12296148text
Measure
percent_inhibition
Value
17,735 ± 4316 RFU
Target
Mus musculus
Assay
Not reported by source
Source publication
Metabolic/CardiovascularOtherPositive observation
Record detail

Recombinant APA accelerated the return of the SBP to pre-infusion levels elicited by Ang I (Figure 4 in the left panel) (p = 0.0266).

Mention PMC12296148::PEP000001PMC12296148text
Measure
survival_rate
Value
p = 0.0266
Target
Mus musculus
Assay
Not reported by source
Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.