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PEPDIA-INT-080721

Gold

Angiotensin II

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

DRVYIHPFHL

Indexed sequence10 aa

1DRVYIHPFHL

Length

Molecular weight

1296.50 Da

Formula

C62H89N17O14

Structure type

Linear

Synthesis

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic5

Membrane affinity proxy

Polar0

Solubility proxy

Charged4

Net charge proxy +2

Aromatic4

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1296.4754 Da

Molecular formula

C62H89N17O14

Theoretical pI

6.9184

Net charge at pH 7

-0.0654

GRAVY

-0.2

Instability index

22.64

Aromaticity

0.2

Topological polar surface area

493.22 Å²

cLogP

-1.1235

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

DRVYIHPFHL

HELM 2.0

validated simple linear

PEPTIDE1{D.R.V.Y.I.H.P.F.H.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(N)CC(=O)O)C(C)C)C(=O)NC(Cc1c[nH]cn1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(C)C)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-080721,
  title = {Angiotensin II},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-080721},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Angiotensin II. (2026). PepDiana record PEPDIA-INT-080721. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-080721

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (5 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P080721_ACT_ahtpdb_0000	Metabolic/Cardiovascular	ACE Inhibitor	75.86 µM	Unknown	Not reported by source	2434ahtpdb / linked
CTPDB_P080721_ACT_ahtpdb_0001	Metabolic/Cardiovascular	ACE Inhibitor	Not available for this observation	Unknown	Not reported by source	2976ahtpdb / linked
CTPDB_P080721_ACT_satpdb_0002	Metabolic/Cardiovascular	Antihypertensive	Not available for this observation	Unknown	Not reported by source	satpdb22443satpdb / linked
CTPDB_P080721_ACT_satpdb_0003	Bioregulatory	Cell-Cell Communication	Not available in the current structured import	Unknown	Not reported by source	satpdb22443satpdb / linked
CTPDB_P080721_ACT_satpdb_0004	Cell-Penetrating	Drug Delivery	Not available in the current structured import	Unknown	Not reported by source	satpdb22443satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003454 View all experimental records

Provenance

Source database records (4)

ahtpdb

2434

Raw sequence

DRVYIHPFHL

ahtpdb

2976

Raw sequence

DRVYIHPFHL

b3pdb

b3pdb_0717

Raw sequence

DRVYIHPFHL

satpdb

satpdb22443

Raw sequence

DRVYIHPFHL

Citation trail

Literature (3 records)

A new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides.

Sagardia I1, Roa-Ureta RH, Bald C.

Food Chem. 2013 Feb 15;136(3-4):1370-6.2013PMID 23194537

VPPIPP and IPPVPP: two hexapeptides innovated to exert antihypertensive activity.

Ding F1, Qian B, Zhao X, Shen S, Deng Y, Wang D, Zhang F, Sui Z, Jing P.

PLoS One. 2013 Apr 30;8(4):e62384.2013PMID 23638059

{"pubmed_id": "[NA](https://www.ncbi.nlm.nih.gov/pubmed/?term=NA)"}

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.113046+00:00

Modification summary

No structured modification annotations are available for this record.

Source metadata

[
  {
    "source_db": "ahtpdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "b3pdb",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCSSCCSCCC"
}