ProForma 2.0
Not calculated for this record
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Primary-literature peptidemedium evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003454
Ang I
Aliases: Ang I
Normalized sequence
DRVYIHPFHL
10 amino acids
Release PepDiana-V1-20260620
2
Activity records
1
Source papers
2
Positive
0
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 2 records
PMC12296148
2 observationsMetabolic/CardiovascularOtherPositive observation
Record detail In the in vitro assay, the murine rAPA (mrAPA) showed a substantial cleavage of aspartate from Ang I (17,735 ± 4316 RFU, N= 4).
- Measure
- percent_inhibition
- Value
- 17,735 ± 4316 RFU
- Target
- Mus musculus
- Assay
- Not reported by source
Metabolic/CardiovascularOtherPositive observation
Record detail Recombinant APA accelerated the return of the SBP to pre-infusion levels elicited by Ang I (Figure 4 in the left panel) (p = 0.0266).
- Measure
- survival_rate
- Value
- p = 0.0266
- Target
- Mus musculus
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003454, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00