Back to Primary literature

Primary-literature peptidemedium evidence

PEPDIA-PLP-002269

L-glutamine

Aliases: L-glutamine

Normalized sequence

Q

1 amino acids

Release PepDiana-V1-20260620

16

Activity records

1

Source papers

16

Positive

0

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

146.1445 Da

Molecular formula

C5H10N2O3

Theoretical pI

5.525

Net charge at pH 7

-0.2399

GRAVY

-3.5

Instability index

0

Aromaticity

0

Topological polar surface area

106.41 Å²

cLogP

-1.3362

Hydrogen-bond donors

3

Hydrogen-bond acceptors

3

Rotatable bonds

4

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

Q

HELM 2.0

validated simple linear

PEPTIDE1{Q}$$$$V2.0

Canonical SMILES

validated

NC(=O)CCC(N)C(=O)O

Isomeric SMILES

validated

NC(=O)CC[C@H](N)C(=O)O

Paper-level observations

Experimental evidence grouped by activity

Toxicity 4 records

PMC13077270

4 observations

ToxicityCytotoxicPositive observation

CCK-8 assays demonstrated that GLU (1.25-20 mM) ... had no adverse effects on FCA-L2 cell viability.

Mention PMC13077270::PEP000001PMC13077270text

Measure: cell_viability
Value: no adverse effects
Target: FCA-L2
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

higher concentrations (40-80 mM GLU ...) demonstrated slight promotive effects on cell growth, confirming their safety.

Mention PMC13077270::PEP000001PMC13077270text

Measure: cell_viability
Value: slight promotive effects
Target: FCA-L2
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

treatment with 40 mM GLU ... restored cell morphology and increased the relative density to 85.89 ...%

Mention PMC13077270::PEP000001PMC13077270text

Measure: cell_viability
Value: 85.89% % of NC
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

GLU ... treatment effectively mitigated this effect, reducing the intensity to 314.27 ...%

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 314.27% % of NC
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

Other 4 records

PMC13077270

4 observations

OtherAntibacterialPositive observation

Claudin increased from 59.76 pg/mg (SP) to 74.22 (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: fold_change
Value: 74.22 pg/mg
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

OtherAntibacterialPositive observation

ZO-1 increased from 395.17 to 484.65 ... (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: fold_change
Value: 484.65 ng/mg
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

OtherAntibacterialPositive observation

occludin increased from 84.39 to 99.20 ... (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: fold_change
Value: 99.20 ng/mg
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

OtherAntibacterialPositive observation

E-cadherin, its expression was significantly restored by GLU treatment, increasing from 424.23 ng/mg in the SP group to 465.27 ng/mg.

Mention PMC13077270::PEP000001PMC13077270text

Measure: fold_change
Value: 465.27 ng/mg
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

Immunomodulatory 3 records

PMC13077270

3 observations

ImmunomodulatoryAnti-inflammatoryPositive observation

IL-1β decreased from 96.96±4.66 pg/ml (SP) to 75.61±7.01 pg/ml (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 75.61±7.01 pg/ml
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

TNF-α decreased from 19.88±1.85 pg/ml to 16.72±1.07 ... (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 16.72±1.07 pg/ml
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

ImmunomodulatoryAnti-inflammatoryPositive observation

IL-8 decreased from 60.02±4.47 pg/ml to 55.67±2.80 ... (GLU + SP)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 55.67±2.80 pg/ml
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

Antioxidant 3 records

PMC13077270

3 observations

AntioxidantAntibacterialPositive observation

SP infection significantly elevated MDA levels ... These alterations were significantly reversed by both GLU ... treatment.

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: significantly reversed
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

SP infection significantly ... reduced SOD ... activities ... These alterations were significantly reversed by both GLU ... treatment.

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: significantly reversed
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

AntioxidantAntibacterialPositive observation

SP infection significantly ... reduced ... GPX activities ... These alterations were significantly reversed by both GLU ... treatment.

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: significantly reversed
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

Antimicrobial 2 records

PMC13077270

2 observations

AntimicrobialAntibacterialPositive observation

treatment with GLU reduced LDH release to 225.86±17.42% (40 mM)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 225.86±17.42% % of NC
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

treatment with GLU reduced LDH release to ... 228.05±15.29% (80 mM)

Mention PMC13077270::PEP000001PMC13077270text

Measure: percent_inhibition
Value: 228.05±15.29% % of NC
Target: Streptococcus pneumoniae
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-002269, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00