AptaDB: Result

Interaction ID: 1273

Aptamer sequence: ACUAGCCUCAUCAGCUCAUGUGCCCCUCCGCCUGGAUCAC

Target unique ID: O15123

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1211	Seq1	Protein	ANGP2_HUMAN	2.2 nM	N/A	25866800

Aptamer Sequence:	ACUAGCCUCAUCAGCUCAUGUGCCCCUCCGCCUGGAUCAC
The optimal secondary structure in dot-bracket notation:	.((((........((......))........)))).....
The centroid secondary structure in dot-bracket notation:	........................................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1211	Description	Seq1
Aptamer chemistry	RNA	Length	40 nt
GC content	60.0%	Molecular weight	12,602.49 Da
Molarity of 1 μg/μl solution	79.35 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	ACUAGCCUCAUCAGCUCAUGUGCCCCUCCGCCUGGAUCAC
Applications	Binding to angiopoietin-2

Type	Detail	Type	Detail
Uniprot ID	O15123	Protein name	Angiopoietin-2 (ANG-2)
Gene name(s)	ANGPT2	Organism	Angiopoietin-2 (ANG-2)
Status	reviewed in uniprot database	Length	496
Mass	56,919	Activity regulation	N/A
Involvement in disease	Lymphatic malformation 10 (LMPHM10)	Catalytic activity	N/A
PDB ID(s)	1Z3S;1Z3U;2GY7;4JZC;4ZFG;
Function	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling.

No relevant experimental diagram	Interaction ID	1273
	Target type	Protein
	Target unique ID	O15123
	Activity	2.2 nM
	Binding Conditions/Buffer	N/A
	Assay	N/A
	PubMed ID	25866800

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1122	RNA	ACAACCCGGAACAACGUCUAACAGUGUACCAUAACCCGGCAUUCA	53.33%
Apta_292	RNA	CUACGAACUCAUGACACAAGGAUGCAAUCUCAUCCCGCCAGCCCACCGU	53.06%
Apta_1143	RNA	ACGAGUUGUCGCAUGUGCGGUUCAGUCUGGUCCUUCAGCACCGUACAACAA	52.94%
Apta_1	RNA	ACGAAGCUUGAUCCCGUUUGCCGGUCGAUCGCUUCGA	52.50%
Apta_384	RNA	AUGAUCAAUCGCCUCAAUUCGACAGGAGGCUCAC	52.50%
Apta_709	RNA	AGUGAUACCAGCAUCGUCUUGAUGCCCUUGGCAGCACU	52.50%
Apta_91	RNA	GAUAACCUCGAUGCGACGUUCGGCCUCAAAAUCAA	50.00%
Apta_152	RNA	UUACCACGCGCUCUUAACUGCUAGCGCCAUGGC	50.00%
Apta_172	RNA	GGAGACAUCCCUCUUGUUGGUGGUGCCGUGUGGAUGUCUC	50.00%
Apta_314	RNA	GGUUACCAGCCUUCACUGCUCCCGGACGCGUCUGUAUCCGCUACCCGCCGCACCACGGUCGGUCACAC	50.00%
Apta_603	RNA	CUUGUCUGAACAAUUUCGUCUGCCUUUGCGUUCCGACGGC	50.00%
Apta_766	RNA	GGUUACCAGCCUUCACUGCGGACGGACAGAGAGUGCAACCUGCCGUGCCGCACCACGGUCGGUCACAC	50.00%
Apta_575	RNA	AGAGCUUGACGGUCCCGAGAGUCGAGCCCAAGCUGACACUGGACCUUUGCGGACCACGUGUUGAUCGUCG	48.57%
Apta_431	RNA	CAGGCAUGCCUAGCUAAGCAGCCCAUGGCUUAUGCGCGGAAUAUUGGCUUCCGUUC	48.21%
Apta_269	RNA	AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC	48.08%
Apta_301	RNA	AUACCAGCUUAUUCAAUUGCCUGAAAAGUUGAACUCCAAAUACGCGCUGAGAUAGUAAGUGCAAUCU	47.76%
Apta_242	RNA	GCUUCCAGGAAGAGAAGUGUCAUGUGAUCAGUCCUGGUGGGUGG	47.73%
Apta_303	RNA	CCUCCGGCUCAUACCUUUUCGAAGACAAGCUUCGACAGGAGG	47.62%
Apta_51	RNA	GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC	47.50%
Apta_86	RNA	GAAACGACUCGACAACCUCGAGCGACGUGAAUCAU	47.50%

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