Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 808
Aptamer sequence: TACCAGTGCGATGCTCAGGCCGATGTCAACTTTTTCTAACTCACTGGTTTTGCCTGACGCATTCGGTTGAC
Target unique ID: HTB-119
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_726 | HCH07 | Cell | small-cell lung cancer (SCLC) cell | 38 nM | 4.5 g/L Glucose, 5 mM MgCl2, and 1 mg/mL BSA in Dulbecco's PBS (pH 7.3) | 18338423 |
Structure information of aptamer
| Aptamer Sequence: | TACCAGTGCGATGCTCAGGCCGATGTCAACTTTTTCTAACTCACTGGTTTTGCCTGACGCATTCGGTTGAC |
| The optimal secondary structure in dot-bracket notation: | .(((((((((....((((((.((..(((................))).)).)))))))))))).))).... |
| The centroid secondary structure in dot-bracket notation: | .(((((((((....((((((......(..................).....)))))))))))).))).... |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_726 | Description | HCH07 |
| Aptamer chemistry | DNA | Length | 71 nt |
| GC content | 49.3% | Molecular weight | 21,767.92 Da |
| Molarity of 1 μg/μl solution | 45.94 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Aptasensor |
| Sequence | TACCAGTGCGATGCTCAGGCCGATGTCAACTTTTTCTAACTCACTGGTTTTGCCTGACGCATTCGGTTGAC | ||
| Applications | Early lung cancer detection | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| ATCC ID | HTB-119 | Cell name | small-cell lung cancer (SCLC) cell |
| Category | Human cells | Organism | Homo sapiens, human |
| Product type | N/A | Cell type | N/A |
| Morphology | floating aggregates | Tissue | Lung |
| Disease | Carcinoma | Product format | Frozen |
| Antigen expression | myc+; myb+; fes+; fms+; raf+; ras+ | Genes expressed | N/A |
| Cell description | N/A |
|
|
| Application(s) | 3D cell culture; Cancer research | ||
Activity data
 |
Interaction ID | 808 |
| Target type | Cell | |
| Target unique ID | HTB-119 | |
| Activity | 38 nM | |
| Binding Conditions/Buffer | 4.5 g/L Glucose, 5 mM MgCl2, and 1 mg/mL BSA in Dulbecco's PBS (pH 7.3) |
|
| Assay | Specific binding of molecular aptamers to formalin-fixed, paraffin-embedded SCLC cell line tissue arrays |
|
| PubMed ID | 18338423 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_788 | DNA | TACCAGTGCGATGCTCAGTAACTTTGAAGGAAAGGCTACAAACTCTTCCTGACGCATTCGGTTGAC | |
| Apta_734 | DNA | TCCTCGATGCACCAGTTCACCTTATTTGCTTCTTCTCTCTGTTCTGACTGGGTGCTGAGGA | |
| Apta_921 | DNA | ATCCAGAGTGACGCAGCACGAGCCAGACATCTCACACCTGTTGCATATACATTTTGCATGGACACGGTGGCTTAGT | |
| Apta_357 | DNA | ACAATGTCGCTCTCCGCCGCAGGAGCATTGTCTGTCTTTATGCTTCTCTTTTTTGTTGC | |
| Apta_910 | DNA | TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA | |
| Apta_657 | DNA | CCTGCACCTCGTCCAGCATGCACACCGATGGCGGTCCTGTTTTACGGTAGCTTATATGCAGGGGGTGTGCGTGGGGAGGTGCGGTTGC | |
| Apta_944 | DNA | ATACGACTCACTATTAGGGACAAAGCTGACAACCCTTTCATAATCTAACTACATTTATGTGCTAGACTACTGACTAC | |
| Apta_798 | DNA | GTTCGTGGTGTGCTGGATGTCGGAGATGGTCCGCTTCGTTCAACTACTACGCATTTTGACACATCCAGCAGCACGA | |
| Apta_920 | DNA | ATCCAGAGTGACGCAGCACGGCACTCACTCTTTGTTAAGTGGTCTGCTTCTTAACCTTCATCGACACGGTGGCTTA | |
| Apta_1293 | DNA | ATCCAGAGTGACGCAGCATGCCCTAGTTACTACTACTCTTTTTAGCAAACGCCCTCGCTTTGGACACGGTGGCTTAGT | |
| Apta_178 | DNA | AGCAGCACAGAGGTCAGATGCGGTATGCTGGGTCATCTAACTGGGGATATTCTGATATTGCCTATGCGTGCTACCGTGAA | |
| Apta_1182 | DNA | GAATTCAGTCGGACAGCGTCAGTCGTCCCTTTATGCTTGGTGCTCACCGTCTGAATTTCTTCAGATGGACGAATATCGTCTCCC | |
| Apta_585 | DNA | GATCGAGGGCAGCGATAGCTGGGCTAATAAGGTTAGCCCCATCGGTC | |
| Apta_737 | DNA | ATCGTCTGCTCCGTCCAATAGTGCATTGAAACTTCTGCATCCTCGTTTGGTGTGAGGTCGTGC | |
| Apta_738 | DNA | ATCGTCTGCTCCGTCCAATACCTGCATATACACTTTGCATGTGGTTTGGTGTGAGGTCGTGC | |
| Apta_1005 | DNA | ATAGGAGTCGACCGACCAGACCCGACCTCTCCTTTCATGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1007 | DNA | ATAGGAGTCGACCGACCAGACCCGACCTCTCTTTCATGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1276 | DNA | TCAATGGGATGTTAGTATGCAAAGATATTCTGTTCAGTGTGTGCCCAGGCCCCCAGGG | |
| Apta_219 | DNA | AACCGCCCAAATCCCTAAGAGTCTGCACTTGTCATTTTGTATATGTATTTGGTTTTTGGCTCTCACAGACACACTACACACGCACA | |
| Apta_553 | DNA | TGTACCGTCTGAGCGATTCGTACGAACGGCTTTGTACTGTTTGCACTGGCGGATTTAGCCAGTCAGTGTTAAGGAGTGC |
DEV TOOL
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