Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 774
Aptamer sequence: TACCCGGCGTTCGGGGGGTACCGCTGC
Target unique ID: 135461160
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_702 GR31 Molecule Hexasodium 4-amino-3,6-bis[[4-[[4-chloro-6-[(3-sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2-sulphonatophenyl]azo]-5-hydroxynaphthalene-2,7-disulphonate 33 μM 0.5 M LiCl, 20 mM Tris-Cl (pH 7.6), 1 mM MgCl2 1538766
Structure information of aptamer
Aptamer Sequence: TACCCGGCGTTCGGGGGGTACCGCTGC
The optimal secondary structure in dot-bracket notation: ..((((.....))))............
The centroid secondary structure in dot-bracket notation: ..((((.....))))............
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_702 Description GR31
Aptamer chemistry DNA Length 27 nt
GC content 74.1% Molecular weight 8,309.32 Da
Molarity of 1 μg/μl solution 120.35 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence TACCCGGCGTTCGGGGGGTACCGCTGC
Applications Binding to Reactive Green 19
Target information
Type Detail Type Detail
PubChem ID 135461160 Molecular name Hexasodium 4-amino-3,6-bis[[4-[[4-chloro-6-[(3-sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2-sulphonatophenyl]azo]-5-hydroxynaphthalene-2,7-disulphonate
Molecular formula C40H23Cl2N15Na6O19S6 Molecular weight 1418.9
IUPAC name hexasodium;4-amino-3,6-bis[[4-[[4-chloro-6-(3-sulfonatoanilino)-1,3,5-triazin-2-yl]amino]-2-sulfonatophenyl]diazenyl]-5-hydroxynaphthalene-2,7-disulfonate InChIKey WOSYRUIVNDCHHH-UHFFFAOYSA-H
LogP -12.942 Topological polar surface area 564.35
Hydrogen bond acceptor 34 Hydrogen bond donor 6

Synonym(s):
68110-31-6; 4-amino-3,6-bis4-4-chloro-6-(3-sulphonatophenyl)Amino-1,3,5-triazin-2-ylamino-2-sulphonatophenylazo-5-hydroxyna phthalene-2,7-disulphonate (sodium salt); hexasodium 4-amino-3,6-bis[[4-[[4-chloro-6-[(3-sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2-sulphonatophenyl]azo]-5-hydroxynaphthalene-2,7-disulphonate; Hexasodium 4-amino-3,6-bis((4-((4-chloro-6-((3-sulphonatophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-sulphonatophenyl)azo)-5-hydroxynaphthalene-2,7-disulphonate; Green HE4B; Procion green H-E4BD; Procion Green HE 4BD; C.I. Reactive Green 19; EINECS 268-520-2; C.I. 205075; W-111329; 2,7-Naphthalenedisulfonic acid, 4-amino-3,6-bis((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-sulfophenyl)azo)-5-hydroxy-, hexasodium salt; 2,7-Naphthalenedisulfonic acid, 4-amino-3,6-bis(2-(4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-sulfophenyl)diazenyl)-5-hydroxy-, sodium salt (1:6); 4-Amino-3,6-bis((4-((4-chloro-6-((3-sulfophenyl)-amino)-1,3,5-triazin-2-yl)amino)-2-sulfophenyl)azo)-5-hydroxy-2,7-naphthalenedisulfonic acid, hexasodium salt; Hexasodium 4-amino-3,6-bis[[4-[[4-chloro-6-[(3-sulphonatophenyl)Amino]-1,3,5-triazin-2-yl]amino]-2-sulphonatophenyl]azo]-5-hydroxyna phthalene-2,7-disulphonate

Activity data

No relevant experimental diagram

 Interaction ID 774
Target type Molecule
Target unique ID 135461160
Activity 33 μM
Binding Conditions/Buffer

0.5 M LiCl, 20 mM Tris-Cl (pH 7.6), 1 mM MgCl2
Assay

N/A
PubMed ID 1538766
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_701 DNA GTACTGGCGTTCGGGGGGTACCGCTGC
88.89%
Apta_700 DNA GCAGGGGCGTTCGGGGGGTACCGCTGC
81.48%
Apta_506 DNA AAGCGCGCGAGACTACGTTTGTAGGGATACCGATGTCG 57.89%
Apta_679 DNA CAGGTGGCAGATCGGGTGTGGGTGGCCTGG 56.67%
Apta_779 DNA TACGGGCTGGATCCACTGTTACGGCGTGTATCCGCTATCAA 56.10%
Apta_968 DNA TAACACGACAGACGTTCGGAGGTCGAACCCTGACAGCGTGGGC 55.81%
Apta_18 DNA TGGGGGGTTGGACGGGCGGGGCTGC 55.56%
Apta_20 DNA AGAGGGGGGGGTGGGGGTGGCCTGC 55.56%
Apta_546 DNA CACGGCATGGTGGGCGTCGTG 55.56%
Apta_552 DNA CACCTGGGGGAGTATTGCGGAGGAAGGTTCCAGGTG 55.56%
Apta_1019 DNA ATCCCTGCAGTTTGGTAGGGTGCAGG 55.56%
Apta_255 DNA TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT 53.33%
Apta_676 DNA TCAGTCCCGATCAGGTGTGGGTGGCATTGG 53.33%
Apta_146 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG 52.94%
Apta_862 DNA TGTGCCAAAGAGAGTGGTGGGGGGGTGGGCGGAACTCGCG 52.50%
Apta_915 DNA ACTTCGGCTAGTTAGGGGGTAGTTTAGATCGTCTCTACAT 52.50%
Apta_12 DNA TGAGGGGGTGGGTGGGACGGGTTGG 51.85%
Apta_15 DNA TGAGGGGGGGGGAGGGCGGGGCTGC 51.85%
Apta_19 DNA TGAGGGGGGGGGAGGTCGGGCCTGC 51.85%
Apta_24 DNA TGTGGGGATGGATGGGCCGGGCTGC 51.85%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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