Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 702
Aptamer sequence: CAGAGGGAGUACUGAUCAACCCGAGCCUUCCGUCCCUGAG
Target unique ID: 13283
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_659 M3 Molecule 4,4'-Methylenebis(2-methylaniline) 2 μM 250 mM NaCl, 50 mM Tris-HCl, 5 mM MgCl2 14706642
Structure information of aptamer
Aptamer Sequence: CAGAGGGAGUACUGAUCAACCCGAGCCUUCCGUCCCUGAG
The optimal secondary structure in dot-bracket notation: ...(((((.......((.....))........)))))...
The centroid secondary structure in dot-bracket notation: ...(((((.......((.....))........)))))...
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_659 Description M3
Aptamer chemistry RNA Length 40 nt
GC content 60.0% Molecular weight 12,808.67 Da
Molarity of 1 μg/μl solution 78.07 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence CAGAGGGAGUACUGAUCAACCCGAGCCUUCCGUCCCUGAG
Applications Detection of DNA damaging compounds and ultimately DNA adducts
Target information
Type Detail Type Detail
PubChem ID 13283 Molecular name 4,4-Methylenebis(2-methylaniline)
Molecular formula C15H18N2 Molecular weight 226.32
IUPAC name 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline InChIKey WECDUOXQLAIPQW-UHFFFAOYSA-N
LogP 3.059 Topological polar surface area 52.04
Hydrogen bond acceptor 2 Hydrogen bond donor 2

Synonym(s):
838-88-0; 4,4'-Methylenebis(2-methylaniline); 4,4'-Diamino-3,3'-dimethyldiphenylmethane; MBOT; ME-Mda; 3,3'-Dimethyl-4,4'-diaminodiphenylmethane; 4,4'-Methylenedi-o-toluidine; 4,4'-Methylene bis(2-methylaniline); Benzenamine, 4,4'-methylenebis[2-methyl-; Bis(3-methyl-4-aminophenyl)methane; Bis-4-amino-3-methylfenylmethan; 4,4'-Methylenebis(o-toluidine); o-Toluidine, 4,4'-methylenedi-; UNII-OM5XWD3S2I; 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline; Bis(4-amino-3-methylphenyl)methane; NSC 37146; 4,4'-Methylene-bis(2-methylaniline); Aniline, 4,4'-methylenebis(2-methyl-; Methane, bis(4-amino-3-methylphenyl)-; 2,2'-Dimethyl-4,4'-methylenedianiline; 4,4'-METHYLENEBIS(2-METHYLBENZENAMINE); OM5XWD3S2I; 4,4'-methanediylbis(2-methylaniline); Benzenamine, 4,4'-methylenebis(2-methyl-; 4,4'-Methylenebis-o-toluidine; CHEBI:82343; MFCD00126963; DSSTox_CID_867; 3,3'-Dimethyl-4,4'-diaminodiphenylmethane;4,4'-Methylene-bis(2-methylaniline); 4-(4-Amino-3-methylbenzyl)-2-methylphenylamine; DSSTox_RID_75835; DSSTox_GSID_20867; 4,4'-Methylenebis[2-methylaniline]; 4,4'-Methylenebis[2-methylbenzenamine]; Methane, bis[4-amino-3-methylphenyl]-; CAS-838-88-0; CCRIS 391; 4,4'-Methylene di-o-toluidine; EINECS 212-658-8; BRN 0398069; Bis-4-amino-3-methylfenylmethan [Czech]; 4,4'-methylene di-ortho-toluidine; 3,3'-dimethyl-4,4' diaminodiphenylmethane; EC 212-658-8; TimTec1_005368; Oprea1_517776; o-Toluidine,4'-methylenedi-; 3-13-00-00496 (Beilstein Handbook Reference); MLS000719870; SCHEMBL237201; CHEMBL313443; 4-[(4-amino-3-methyl-phenyl)methyl]-2-methyl-aniline; DTXSID5020867; WECDUOXQLAIPQW-UHFFFAOYSA-; ZINC78247; 4,4'-Methylene-di(o-toluidine); HMS1549D22; HMS2757J17; WLN: ZR B1 D1R DZ C1; Aniline,4'-methylenebis(2-methyl-; NSC37146; Tox21_202372; Tox21_300201; NSC-37146; STK760092; 4,4?-Methylene-bis(2-methylaniline); AKOS001483357; 4,4`-Methylen-bis(2-methyl aniline); Benzenamine,4'-methylenebis[2-methyl-; CCG-103180; MCULE-5798656388; NCGC00173286-01; NCGC00173286-02; NCGC00173286-03; NCGC00253955-01; NCGC00259921-01; AC-10919; L405; o-Toluidine, 4,4'-methylenedi- (8CI); SMR000304399; SY052545; 4,4'-diamino-3,3'-dimethyldiphenyl methane; D2046; EU-0000098; FT-0706613; 3,3/'-Dimethyl-4,4/'-diaminodiphenylmethane; 4,4\\'-Diamino-3,3\\'-Dimethyldiphenylmethane; C19260; D89983; Q229843; SR-01000389448; 4-(4-Amino-3-methylbenzyl)-2-methylphenylamine #; SR-01000389448-1; W-104130; Spiro[furo[3,4-b]pyridine-5(7H),4-piperidin]-7-one; 4,4'-Methylene-bis(2-methylaniline), analytical standard; 4,4 inverted exclamation mark -Methylenebis(2-methylaniline); 4,4'-Diamino-3,3'-dimethyldiphenyl methane 100 microg/mL in Acetonitrile

Activity data

No relevant experimental diagram

 Interaction ID 702
Target type Molecule
Target unique ID 13283
Activity 2 μM
Binding Conditions/Buffer

250 mM NaCl, 50 mM Tris-HCl, 5 mM MgCl2
Assay

N/A
PubMed ID 14706642
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_632 RNA GACGAGAAGGAGUGCUGGUUAUACUAGCGGUUAGGUCACUCGUC 56.82%
Apta_86 RNA GAAACGACUCGACAACCUCGAGCGACGUGAAUCAU 55.00%
Apta_315 RNA GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA 52.94%
Apta_660 RNA UGGGAGGAGUGCUGCUCUCCAGGCACUCUUGUUGCUCGGA 52.50%
Apta_129 RNA GGGAGGACGAUGCGGACACCGUUAAUCUGAGGCCCUGUCCUAUUCCUUCACGCCUCAGA 50.85%
Apta_370 RNA GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG 50.00%
Apta_645 RNA CUGGACGACGGGGACGCCACUGGACUAGGUAAGCCAGGACCGUACGUCGGGAGCCGUCAGAAUA 50.00%
Apta_1058 RNA GUAAGGCAGCUUACAAACAUUAAGGCACAG 50.00%
Apta_133 RNA GGGAGGACGAUGCGGUGAGUCGUUCCCUUCGUCCCCAGACGACUCGCCCGA 49.02%
Apta_135 RNA GGGAGGACGAUGCGGAUUCUGGUUACUGGCCGCCCCAGACGACUCGCCCGA 49.02%
Apta_1143 RNA ACGAGUUGUCGCAUGUGCGGUUCAGUCUGGUCCUUCAGCACCGUACAACAA 49.02%
Apta_292 RNA CUACGAACUCAUGACACAAGGAUGCAAUCUCAUCCCGCCAGCCCACCGU 48.98%
Apta_983 DNA ATGGGAACAGAGCGGCGCAGAGACCCAATGCCACGAGTACCTGACCCTATCAACCCGTGA 48.33%
Apta_155 RNA GACCCAGGGCCGGGACGCAAAGCAGCCAAAACAGACGGCCCCAGUCAGGGAGUU 48.15%
Apta_856 RNA UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA 47.92%
Apta_241 RNA GCUUGACGGAGAUCAAGGGCGAGUCUCAUACCAAGUUGAUGGGG 47.73%
Apta_242 RNA GCUUCCAGGAAGAGAAGUGUCAUGUGAUCAGUCCUGGUGGGUGG 47.73%
Apta_303 RNA CCUCCGGCUCAUACCUUUUCGAAGACAAGCUUCGACAGGAGG 47.62%
Apta_98 RNA CGAUGCGGUCUCAUGCGUCGAGUGUGAGUUUACCUUCG 47.50%
Apta_230 RNA GGGAGGACGAUGCGGGCGUGAAUGGUGUUGUGAGG 47.50%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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