Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 583
Aptamer sequence: GGTAATACGACTCACTATAGGGAGATACCAGCTTATTCAATTTTACAGAACAACCAACGTCGCTCCGGGTACTTCTTCATCGAGATAGTAAGTGCAATCT
Target unique ID: 261004
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_550 | Ars-3 | Molecule | Arsenic(III)oxide,arsenic trioxide,arsenous acid anhydride,arsenous acid,arsenic sesquioxide,white arsenic | 4.95 nM | 150 mM NaCl, 50mM HEPES, 0.5 mM MgCl2, 0.5 mM CaCl2 | 20000526 |
Structure information of aptamer
| Aptamer Sequence: | GGTAATACGACTCACTATAGGGAGATACCAGCTTATTCAATTTTACAGAACAACCAACGTCGCTCCGGGTACTTCTTCATCGAGATAGTAAGTGCAATCT |
| The optimal secondary structure in dot-bracket notation: | .........(((.(((((((((((.(((((((.............................)))...)))))))))).......))))).)))....... |
| The centroid secondary structure in dot-bracket notation: | ...................(((((.(((((((.............................)))...)))))))))........................ |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_550 | Description | Ars-3 |
| Aptamer chemistry | DNA | Length | 100 nt |
| GC content | 42.0% | Molecular weight | 30,766.76 Da |
| Molarity of 1 μg/μl solution | 32.50 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Aptasensor |
| Sequence | GGTAATACGACTCACTATAGGGAGATACCAGCTTATTCAATTTTACAGAACAACCAACGTCGCTCCGGGTACTTCTTCATCGAGATAGTAAGTGCAATCT | ||
| Applications | Removal of arsenic | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 261004 | Molecular name | Arsenic(III)oxide,arsenic trioxide,arsenous acid anhydride,arsenous acid,arsenic sesquioxide,white arsenic |
| Molecular formula | As2O3 | Molecular weight | 197.84 |
| IUPAC name | N/A | InChIKey | IKWTVSLWAPBBKU-UHFFFAOYSA-N |
| LogP | -1.068 | Topological polar surface area | 43.37 |
| Hydrogen bond acceptor | 3 | Hydrogen bond donor | 0 |
Synonym(s): MFCD00003433; arsenic(iii)oxide,arsenic trioxide,arsenous acid anhydride,arsenous acid,arsenic sesquioxide,white arsenic; arsenic-trioxide; CHEMBL1200978; Arsenic(III) oxide, elec. gr.; NSC92859; Arsenic(III) oxide, Puratronic(R); Arsenic(III) oxide, primary standard; AKOS015903780; DB01169; Arsenic(III) oxide, p.a., 99.0%; NCGC00164639-02; Arsenic(III) oxide, 99.995% trace metals basis; Arsenic(III) oxide, ReagentPlus(R), >=99.0%; Arsenic(III) oxide, SAJ first grade, >=99.0%; Arsenic(III) oxide, ACS reagent (primary standard); J-006219; Arsenic(III) oxide, puriss. p.a., ACS reagent, 99.95-100.05% (RT); Arsenic(III) oxide, certified reference material for titrimetry, certified by BAM, according to ISO 17025, >99.5%
Activity data
 |
Interaction ID | 583 |
| Target type | Molecule | |
| Target unique ID | 261004 | |
| Activity | 4.95 nM | |
| Binding Conditions/Buffer | 150 mM NaCl, 50mM HEPES, 0.5 mM MgCl2, 0.5 mM CaCl2 |
|
| Assay | Kd values of Ars-3 to arsenate, arsenite, and nine different metals determined individually |
|
| PubMed ID | 20000526 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_792 | DNA | ATACCAGCTTATTCAATTCCCAAATTGCCACCACTTACAGCATGATAACATACTACATCTTTTCATCAAGATAGTAAGTGCAATCT | |
| Apta_625 | DNA | ATACCAGCTTATTCAATTCAGGGCGGTATGAGGCTCGATCAAGGTCGGAGCGAGAATTTTTTCGCGGAGTCGGCTGGATCAGATAGTAAGTGCAATCT | |
| Apta_625 | DNA | ATACCAGCTTATTCAATTCAGGGCGGTATGAGGCTCGATCAAGGTCGGAGCGAGAATTTTTTCGCGGAGTCGGCTGGATCAGATAGTAAGTGCAATCT | |
| Apta_349 | DNA | ATACCAGCTTATTCAATTAGACGAGTTTTATTCATTTTCCATGTCGTAGCTTACCGTGAGATAGTAAGTGCAATCT | |
| Apta_354 | DNA | ATACCAGCTTATTCAATTCTATACTCCACTTTGCTATTTCTCGGTTCCTTCACGCGCCGATCGCAGGCTGATGAATTGAGATAGTAAGTGCAATCT | |
| Apta_823 | DNA | GGGATACCAGCTTATTCAATTTGATTCCATCTTCCTGGACTGTCGAAAATTCAGTATCGGGAGGTTACGTATTTGGTTTATAGATAGTAAGTGCAATCT | |
| Apta_1114 | DNA | TAATACGACTCACTATAGGGAGACCCAAGCCGATTTATTTTGTGCAGCTTTTGTTCCCTTTAGTGAGGGTTAATT | |
| Apta_627 | DNA | ATACCAGCTTATTCAATTATGCGGGGATGAGGCTTGATCTGTGGCTCTGATCCATGATCAGTCGTCTTACGTGCGGTCCAGATAGTAAGTGCAATCT | |
| Apta_727 | DNA | ATACCAGCTTATTCAATTAGTCACACTTAGAGTTCTAACTGCTGCGCCGCCGGGAAAATACTGTACGGTTAGATAGTAAGTGCAATCT | |
| Apta_932 | DNA | ATACGACTCACTATTAGGGATGTCCACCATATAGATCGATTTAAGTCCCTCGTTATTAATGCTAGACTACTGACTACAA | |
| Apta_1103 | DNA | TACGACTCACTATAGGGATCCACCTATGGCAGATTGAGCCCAAGGGCTGTGCAGCGAATTCCCTTTAGTGAGGGTT | |
| Apta_627 | DNA | ATACCAGCTTATTCAATTATGCGGGGATGAGGCTTGATCTGTGGCTCTGATCCATGATCAGTCGTCTTACGTGCGGTCCAGATAGTAAGTGCAATCT | |
| Apta_281 | DNA | CCGTAATACGACTCACTATAGGGGAGCTCGGTACCGAATTCATGTTGGTAGTTGGCTTGTGTTCGTGTGTTAAGCTTTCAGAGAGGATCCTT | |
| Apta_451 | DNA | ATACCAGCTTATTCAATTGAGTAAGAGTGCACTATGTTTTACGAGCCGTTTCCTCGGCAGATAGTAAGTGCAATCT | |
| Apta_628 | DNA | ATACCAGCTTATTCAATTAGCCCGGTATTGAGGTCGATCTCTTATCCTATGGCTTGTCCCCCATGGCTCGGTTATATCCAGATAGTAAGTGCAATCT | |
| Apta_884 | DNA | ATACCAGCTTATTCAATTTGCACCACTTATTGTTACTAATCTGAGATAGTAAGTGCAATCT | |
| Apta_931 | DNA | ATACGACTCACTATTAGGGACCACATAAACATGCATCGCTCAATAACGGGATATTGTTGTGCTAGACTACTGACTACAA | |
| Apta_1015 | DNA | ATACCAGCTTATTCAATTGACCCGTTTCGTTCCCTCTGGGAAGTTTAGCCCAGTTGCCTGGGCGATACCAAGATAGTAAGTGCAATCT | |
| Apta_1101 | DNA | CCGTAATACGACTCACTATAGGTATGTGACGCGCGTCAATCGCTGTCCTACCAAGCTTTGCAGAGAGGATCCTT | |
| Apta_628 | DNA | ATACCAGCTTATTCAATTAGCCCGGTATTGAGGTCGATCTCTTATCCTATGGCTTGTCCCCCATGGCTCGGTTATATCCAGATAGTAAGTGCAATCT |
DEV TOOL
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