AptaDB: Result

Interaction ID: 451

Aptamer sequence: AGCCATGACGATGTCGTTACGTAGATGCATAGACTCCTAA

Target unique ID: Q13651

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_446	#411-J-G30T	Protein	I10R1_HUMAN	18 nM	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)	26007661

Aptamer Sequence:	AGCCATGACGATGTCGTTACGTAGATGCATAGACTCCTAA
The optimal secondary structure in dot-bracket notation:	.....(((((....))))).....................
The centroid secondary structure in dot-bracket notation:	......((((....))))......................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_446	Description	#411-J-G30T
Aptamer chemistry	DNA	Length	40 nt
GC content	45.0%	Molecular weight	12,303.94 Da
Molarity of 1 μg/μl solution	81.27 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	AGCCATGACGATGTCGTTACGTAGATGCATAGACTCCTAA
Applications	Bind human receptors and cross-react with their murine orthologs

Type	Detail	Type	Detail
Uniprot ID	Q13651	Protein name	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Gene name(s)	IL10RA IL10R	Organism	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Status	reviewed in uniprot database	Length	578
Mass	63,003	Activity regulation	N/A
Involvement in disease	Inflammatory bowel disease 28, autosomal recessive (IBD28)	Catalytic activity	N/A
PDB ID(s)	1J7V;1LQS;1Y6K;1Y6M;1Y6N;5IXI;6X93;
Function	Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.

No relevant experimental diagram	Interaction ID	451
	Target type	Protein
	Target unique ID	Q13651
	Activity	18 nM
	Binding Conditions/Buffer	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)
	Assay	N/A
	PubMed ID	26007661

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_438	DNA	AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA	97.50%
Apta_438	DNA	AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA	97.50%
Apta_443	DNA	GGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA	95.00%
Apta_444	DNA	AGCCATTACGATGTCGTTACGTAGATGCAGAGACTCCTAA	95.00%
Apta_445	DNA	AGCCATGACGATGTCGTTACGTAGATGTAGAGACTCCTAA	95.00%
Apta_883	DNA	CGTACCGGCCAGTGATTACGACGAGACGAGCTTATGCGTATTGATGCCTAACTATCTACA	56.67%
Apta_820	DNA	TCCCACGATCTCATTAGTCTGTGGATAAGCGTGGGACGTCTATGA	55.56%
Apta_162	DNA	CCGTACATACTACGTACGTACGTGAACAGAGGCAGAG	55.00%
Apta_185	DNA	ACCAAGGCTTTAGGTCTGAGATCTCCCAAT	55.00%
Apta_222	DNA	AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT	55.00%
Apta_911	DNA	GGCCATTGTGGACTTCTTTGGGTAATTCAGGGGCTCGATT	55.00%
Apta_964	DNA	CACGAGAGGGGTGAGGTGTCGTATTAGAGGGAAGCTCCAA	55.00%
Apta_1204	DNA	GGCACGATGTGGCTACATCGATCGCGGTACTGGTG	55.00%
Apta_1204	DNA	GGCACGATGTGGCTACATCGATCGCGGTACTGGTG	55.00%
Apta_238	DNA	CACACATTCCCGTCCTCGATACGTCTAGGCTTAGTGCCACTTGCTTAATC	54.00%
Apta_395	DNA	AATCCACGTATCGACTAGCTCAAACCAGCCTGATAGAGCCATTCGCTTTA	54.00%
Apta_969	DNA	TAACCACCCCACCTCGCTCCCGTGACACTAATGCTAATTCCAA	53.49%
Apta_309	DNA	TAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTAC	53.06%
Apta_421	DNA	ATCTACGAATTCATCAGGGCTAAAGAGTGCAGAGTTACTTAGCCCGTGA	53.06%
Apta_309	DNA	TAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTAC	53.06%

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