AptaDB: Result

Interaction ID: 376

Aptamer sequence: GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG

Target unique ID: P24821

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_370	TTA1.2	Protein	TENA_HUMAN	2.0 nM	20 mM Tris, pH 7.4; 137 mM NaCl; 1 mM CaCl2; 1 mM MgCl2	15509871

Aptamer Sequence:	GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG
The optimal secondary structure in dot-bracket notation:	(((((...(((((.........)))))....)))))..
The centroid secondary structure in dot-bracket notation:	(((((...(((((.........)))))....)))))..

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_370	Description	TTA1.2
Aptamer chemistry	RNA	Length	38 nt
GC content	60.5%	Molecular weight	12,225.24 Da
Molarity of 1 μg/μl solution	81.80 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG
Applications	Binding to TN-C

Type	Detail	Type	Detail
Uniprot ID	P24821	Protein name	Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C)
Gene name(s)	TNC HXB	Organism	Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C)
Status	reviewed in uniprot database	Length	2201
Mass	240,853	Activity regulation	N/A
Involvement in disease	Deafness, autosomal dominant, 56 (DFNA56)	Catalytic activity	N/A
PDB ID(s)	1TEN;2RB8;2RBL;5R5T;5R5U;5R5V;5R5W;5R5X;5R5Y;5R5Z;5R60;5R61;5R62;5R63;6BRB;6QNV;
Function	Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration.

No relevant experimental diagram	Interaction ID	376
	Target type	Protein
	Target unique ID	P24821
	Activity	2.0 nM
	Binding Conditions/Buffer	20 mM Tris, pH 7.4; 137 mM NaCl; 1 mM CaCl2; 1 mM MgCl2
	Assay	N/A
	PubMed ID	15509871

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_230	RNA	GGGAGGACGAUGCGGGCGUGAAUGGUGUUGUGAGG	63.16%
Apta_712	RNA	GGCGGUGCUCGCCGAAAGGCUCCUGGAUACGUC	57.89%
Apta_129	RNA	GGGAGGACGAUGCGGACACCGUUAAUCUGAGGCCCUGUCCUAUUCCUUCACGCCUCAGA	57.63%
Apta_365	RNA	GGACCUAUGCAGUAGCCAGUGUGGACUGGGCUGCCCCCCC	57.50%
Apta_231	RNA	GGGAGGACGAUGCGGGUGUGGGGCG	55.26%
Apta_560	RNA	GGAAGAGAUGGCGACUAAAACGACUUGUCGC	55.26%
Apta_713	RNA	GGCGGUGCUGGCCGAAAGGCGCUUGGAAACGUC	55.26%
Apta_717	RNA	GGCGCAGCCCGCCGAAAGGCACGUGGAACCGUC	55.26%
Apta_366	RNA	GGUUAGAGGCGACGUCCCGGAAUCCGCGCCCAUUGCCCCC	55.00%
Apta_660	RNA	UGGGAGGAGUGCUGCUCUCCAGGCACUCUUGUUGCUCGGA	55.00%
Apta_312	RNA	GGGAAAAGAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGCCGAGAA	54.90%
Apta_315	RNA	GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA	54.90%
Apta_703	RNA	GGGCGGAUGAGACGCUUGGCGUGUGCUGUGGAGAGUCAUCCG	54.76%
Apta_304	RNA	CGGCCGAUAGAAAGACUACUUGAGCCCUUAAAUGAGGUUAUGUGCGGCCG	54.00%
Apta_131	RNA	GGGAGGACGAUGCGGUCCUGUCGUCUGUUCGUCCCCAGACGACUCGCCCGA	52.94%
Apta_132	RNA	GGGAGGACGAUGCGGCGUUUCCUCUGGUUCGUCCCCAGACGACUCGCCCGA	52.94%
Apta_98	RNA	CGAUGCGGUCUCAUGCGUCGAGUGUGAGUUUACCUUCG	52.63%
Apta_138	RNA	GGAGGUGCUCCGAAAGGAACUCC	52.63%
Apta_711	RNA	GGCGAUACCAGCCGAAAGGCCCUUGGCAGCGUC	52.63%
Apta_714	RNA	GGCGGUUCCUGCCGAAAGGCUCGUGGCAACGUC	52.63%

ABOUT