AptaDB: Result

Interaction ID: 268

Aptamer sequence: AGAGGGGAGGGTCGGGTATCGGCGTGTTCGGGGGATCTGC

Target unique ID: P08637

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_263	CLN0123	Protein	FCG3A_HUMAN	193 nM	DPBS with 0.05% BSA	21531729

Aptamer Sequence:	AGAGGGGAGGGTCGGGTATCGGCGTGTTCGGGGGATCTGC
The optimal secondary structure in dot-bracket notation:	....(((...((((.....))))...)))...........
The centroid secondary structure in dot-bracket notation:	..........((((.....)))).................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_263	Description	CLN0123
Aptamer chemistry	DNA	Length	40 nt
GC content	67.5%	Molecular weight	12,825.97 Da
Molarity of 1 μg/μl solution	77.97 μM	Number of G-quadruplexes	3
G-Score	56	Function	Targeted binding
Sequence	AGAGGGGAGGGTCGGGTATCGGCGTGTTCGGGGGATCTGC
Applications	Binding to target proteins

Type	Detail	Type	Detail
Uniprot ID	P08637	Protein name	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Gene name(s)	FCGR3A CD16A FCG3 FCGR3 IGFR3	Organism	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Status	reviewed in uniprot database	Length	254
Mass	29,089	Activity regulation	N/A
Involvement in disease	Immunodeficiency 20 (IMD20)	Catalytic activity	N/A
PDB ID(s)	3AY4;3SGJ;3SGK;3WN5;5BW7;5D6D;5ML9;5MN2;5VU0;5XJE;5XJF;5YC5;7SEG;
Function	Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).

No relevant experimental diagram	Interaction ID	268
	Target type	Protein
	Target unique ID	P08637
	Activity	193 nM
	Binding Conditions/Buffer	DPBS with 0.05% BSA
	Assay	N/A
	PubMed ID	21531729

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_11	DNA	AGAGGGGGGGGTCGGGGTGGGTCGC	62.50%
Apta_13	DNA	AGGGGGGGGGGAGGGGTCGGGGTGG	60.00%
Apta_15	DNA	TGAGGGGGGGGGAGGGCGGGGCTGC	60.00%
Apta_73	DNA	GGGGAGTAGGTTGGTGTGGTTGGGGCTCCCC	60.00%
Apta_393	DNA	AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	60.00%
Apta_942	DNA	AGTGGGTAAGGTCTGGTGGATTGTGGACGGGGGGCGGGGCAGTGGCTTGA	60.00%
Apta_1188	DNA	CGGGCGGGGCGTGGGGTGTTGGAGTGGAGGGCGGGGCGGC	60.00%
Apta_17	DNA	AGGGGGGGGGGTGGGGGTGGGTCCC	57.50%
Apta_18	DNA	TGGGGGGTTGGACGGGCGGGGCTGC	57.50%
Apta_19	DNA	TGAGGGGGGGGGAGGTCGGGCCTGC	57.50%
Apta_20	DNA	AGAGGGGGGGGTGGGGGTGGCCTGC	57.50%
Apta_25	DNA	TGTGGGGGTGGTTGGGCGGGGCTGC	57.50%
Apta_69	DNA	AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT	57.50%
Apta_71	DNA	GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC	57.50%
Apta_124	DNA	GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC	57.50%
Apta_679	DNA	CAGGTGGCAGATCGGGTGTGGGTGGCCTGG	57.50%
Apta_857	DNA	GCTATGGGTGGTCTGGTTGGGATTGGCCCCGGGAGCTGGC	57.50%
Apta_1014	DNA	TGGGGGTTGGGTGGATAGGCTGGCGTCGGGGCAGGTCAGT	57.50%
Apta_1085	DNA	TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC	57.50%
Apta_1205	DNA	GGCAGGTGGTGTTGGTTGGTTGTGCGTGGAGTTGG	57.50%

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