ProForma 2.0
Not calculated for this record
Back to Primary literature
Primary-literature peptidemedium evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-004051
D
Aliases: D
Normalized sequence
SLLSLIRKLIT
11 amino acids
Release PepDiana-V1-20260620
5
Activity records
1
Source papers
3
Positive
2
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 2 records
PMC10587126
2 observationsAntimicrobialAntibacterialPositive observation
Record detail The template peptides (VmCT1, anoplin, protonectin, decoralin, and temporin A) exhibited MICs against bacterial strains ranging from 0.8 to 25 μmol L−1 (Fig. 3a and Tables S1 and S2).
- Measure
- MIC
- Value
- 0.8–25 μmol L−1
- Target
- multiple bacteria
- Assay
- Not reported by source
AntimicrobialAntiparasiticNegative / threshold
Record detail the parent peptides decoralin and temporin A showed no activity.
- Measure
- percent_inhibition
- Value
- no activity
- Target
- Plasmodium gallinaceum
- Assay
- Not reported by source
Toxicity 2 records
PMC10587126
2 observationsToxicityHemolyticPositive observation
Record detail Hemolytic activity, here defined as the concentration of peptide needed to kill 10% of red blood cells, was observed with the parent peptides decoralin and temporin, which were hemolytic at 1.6 μmol L−1 and 0.2 μmol L−1, respectively.
- Measure
- hemolysis
- Value
- hemolytic at 1.6 μmol L−1
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityCytotoxicNegative / threshold
Record detail After 24 h of incubation, we did not observe peptide-meditated cytotoxicity towards MCF-10A cells (Fig. 3e).
- Measure
- cell_viability
- Value
- did not observe peptide-meditated cytotoxicity
- Target
- MCF-10A
- Assay
- Not reported by source
Anticancer 1 records
PMC10587126
1 observationsAnticancerCytotoxicPositive observation
Record detail VD showed decreased activity compared to its template peptides VmCT1 and decoralin (50 μmol L−1).
- Measure
- other
- Value
- 50 μmol L−1 (LD50)
- Target
- MCF-7
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-004051, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00