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PEPDIA-INT-025104

Gold

Decoralin

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

SLLSLIRKLIT

Indexed sequence11 aa

1SLLSLIRKLIT

Length

Molecular weight

1256.60 Da

Formula

C58H109N15O15

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic6

Membrane affinity proxy

Polar3

Solubility proxy

Charged2

Net charge proxy +2

Aromatic0

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1256.5774 Da

Molecular formula

C58H109N15O15

Theoretical pI

11.0002

Net charge at pH 7

1.4591

GRAVY

1.2273

Instability index

1.3727

Aromaticity

Topological polar surface area

502.93 Å²

cLogP

-2.7194

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

SLLSLIRKLIT

HELM 2.0

validated simple linear

PEPTIDE1{S.L.L.S.L.I.R.K.L.I.T}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(N)CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(C(=O)O)C(C)O)C(C)CC

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)CC

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-025104,
  title = {Decoralin},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-025104},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Decoralin. (2026). PepDiana record PEPDIA-INT-025104. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-025104

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (52 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P025104_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP00723apd / linked
CTPDB_P025104_ACT_apd_0001	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP00723apd / linked
CTPDB_P025104_ACT_apd_0003	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	AP00723apd / linked
CTPDB_P025104_ACT_apd_0004	Anticancer	-	Not available in the current structured import	Unknown	Not reported by source	AP00723apd / linked
CTPDB_P025104_ACT_camp_0005	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ736camp / linked
CTPDB_P025104_ACT_camp_0006	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ736camp / linked
CTPDB_P025104_ACT_camp_0007	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ736camp / linked
CTPDB_P025104_ACT_dbaasp_0008	Antimicrobial	-	40 µM	Staphylococcus aureus CCT 6538	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0009	Antimicrobial	-	40 µM	Staphylococcus saprophyticus	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0010	Antimicrobial	-	40 µM	Bacillus subtilis CCT 2471	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0011	Antimicrobial	-	40 µM	Bacillus thuringiensis	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0012	Antimicrobial	-	80 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0013	Antimicrobial	-	160 µM	Escherichia coli CCT 1371	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0014	Antimicrobial	-	80 µM	Klebsiella pneumoniae ATCC 13883	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0015	Antimicrobial	-	40 µM	Alcaligenes faecalis ATCC 8750	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0016	Antimicrobial	-	40 µM	Candida albicans	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0017	Antimicrobial	-	72 µM	Leishmania major MHOM/SU/73/5ASKH	Not reported by source	DBAASPS_3176_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0018	Antimicrobial	-	4 µM	Staphylococcus aureus CCT 6538	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0019	Antimicrobial	-	20 µM	Staphylococcus saprophyticus	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0020	Antimicrobial	-	8 µM	Bacillus subtilis CCT 2471	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0021	Antimicrobial	-	20 µM	Bacillus thuringiensis	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0022	Antimicrobial	-	40 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0023	Antimicrobial	-	20 µM	Escherichia coli CCT 1371	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0024	Antimicrobial	-	40 µM	Klebsiella pneumoniae ATCC 13883	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0025	Antimicrobial	-	40 µM	Alcaligenes faecalis ATCC 8750	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0026	Antimicrobial	-	20 µM	Candida albicans	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0027	Antimicrobial	-	11 µM	Leishmania major MHOM/SU/73/5ASKH	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0028	Antimicrobial	-	0.8 µM	Micrococcus luteus A270	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0029	Antimicrobial	-	1.6 µM	Escherichia coli SBS 363	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0030	Antimicrobial	-	25 µM	Salmonella enterica subsp. arizonae ATCC 13314	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0031	Antimicrobial	-	6.2 µM	Bacillus subtilis ATCC 6633	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0032	Antimicrobial	-	1.6 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0033	Antimicrobial	-	0.8 µM	Candida albicans MDM8	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dbaasp_0034	Antimicrobial	-	12.5 µM	Human breast adenocarcinoma MCF-7	Not reported by source	DBAASPS_3177_chain0dbaasp / linked
CTPDB_P025104_ACT_dramp_0035	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03056dramp / linked
CTPDB_P025104_ACT_dramp_0036	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP03056dramp / linked
CTPDB_P025104_ACT_dramp_0037	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP03056dramp / linked
CTPDB_P025104_ACT_dramp_0038	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP03056dramp / linked
CTPDB_P025104_ACT_dramp_0039	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP03056dramp / linked
CTPDB_P025104_ACT_hemolytik_0040	Toxicity	Hemolytic	Not available in the current structured import	Erythrocytes	Not reported by source	1857hemolytik / linked
CTPDB_P025104_ACT_hemolytik_0041	Toxicity	Hemolytic	Not available in the current structured import	Erythrocytes	Not reported by source	1858hemolytik / linked
CTPDB_P025104_ACT_hemolytik_0042	Toxicity	Hemolytic	80.0 µM	Erythrocytes	Not reported by source	1859hemolytik / linked
CTPDB_P025104_ACT_parapep_0043	Antiparasitic	Antiparasitic	72.0 µM	Unknown	MTT assay	1575parapep / linked
CTPDB_P025104_ACT_parapep_0044	Antiparasitic	Antiparasitic	11.0 µM	Unknown	MTT assay	1576parapep / linked
CTPDB_P025104_ACT_satpdb_0045	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb16709satpdb / linked
CTPDB_P025104_ACT_satpdb_0046	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb16709satpdb / linked
CTPDB_P025104_ACT_satpdb_0047	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb16709satpdb / linked
CTPDB_P025104_ACT_satpdb_0048	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb24100satpdb / linked
CTPDB_P025104_ACT_satpdb_0049	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb24100satpdb / linked
CTPDB_P025104_ACT_satpdb_0050	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb24100satpdb / linked
CTPDB_P025104_ACT_satpdb_0051	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb24100satpdb / linked
CTPDB_P025104_ACT_satpdb_0052	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb24100satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-004051 View all experimental records

Provenance

Source database records (12)

apd

AP00723

Raw sequence

SLLSLIRKLIT

camp

CAMPSQ736

Raw sequence

SLLSLIRKLIT

dbaasp

DBAASPS_3176_chain0

Raw sequence

SLLSLIRKLIT

dbaasp

DBAASPS_3177_chain0

Raw sequence

SLLSLIRKLIT

dramp

DRAMP03056

Raw sequence

SLLSLIRKLIT

hemolytik

1857

Raw sequence

SLLSLIRKLIT

hemolytik

1858

Raw sequence

SLLSLIRKLIT

hemolytik

1859

Raw sequence

SLLSLIRKLIT

parapep

1575

Raw sequence

SLLSLIRKLIT

parapep

1576

Raw sequence

SLLSLIRKLIT

satpdb

satpdb16709

Raw sequence

SLLSLIRKLIT

satpdb

satpdb24100

Raw sequence

SLLSLIRKLIT

Citation trail

Literature (4 records)

Decoralin, a novel linear cationic alpha-helical peptide from the venom of solitary eumenine wasp Oreumenes decoratus

Konno K, Rangel M, Oliveira JS, Dos Santos Cabrera MP, Fontana R, Hirata IY, Hide I, Nakata Y, Mori K, Kawano M, Fuchino H, Sekita S, Neto JR.2007

Peptides2007PMID 17981364

-

--PMID 28105725

-

--PMID 28795464

Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus.

Konno K, Rangel M, Oliveira JS, dos Santos Cabrera MP, Fontana R, Hirata IY, Hide I, Nakata Y, Mori K, Kawano M, Fuchino H, Sekita S, Neto JR

Peptides2007PMID 30013694

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.203743+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "1000",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "source_db": "dbaasp",
      "assay_method": "-",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "300",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Mouse erythrocytes"
    },
    {
      "unit": "µM",
      "value": "80",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "1.6",
      "source_db": "dbaasp",
      "assay_method": "0% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "100",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Normal breast cells MCF-10a"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.17981364]EC50=1 mM against mouse erythrocytes",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Erythrocytes"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CHHHHTTTSCC"
}