ProForma 2.0
Not calculated for this record
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003524
pep1
Aliases: pep1
Normalized sequence
FLSGIVGMLGKLF
13 amino acids
Release PepDiana-V1-20260620
19
Activity records
1
Source papers
12
Positive
7
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Antimicrobial 10 records
PMC9221442
10 observationsAntimicrobialAnti-Gram-Positive observation
Record detail Table 4: Temporin-SHa MIC on A. baumannii (DSM 30007) = 6.25 µM.
- Measure
- MIC
- Value
- 6.25 µM
- Target
- Acinetobacter baumannii
- Assay
- Not reported by source
AntimicrobialAnti-Gram-Positive observation
Record detail Table 4: Temporin-SHa MIC on E. cloacae (DSM 30054) = 50 µM.
- Measure
- MIC
- Value
- 50 µM
- Target
- Enterobacter cloacae
- Assay
- Not reported by source
AntimicrobialAnti-Gram-Positive observation
Record detail Table 4: Temporin-SHa MIC on E. coli (ATCC 8739) = 50 µM.
- Measure
- MIC
- Value
- 50 µM
- Target
- Escherichia coli
- Assay
- Not reported by source
AntimicrobialAnti-Gram-Positive observation
Record detail Table 4: Temporin-SHa MIC on P. aeruginosa (ATCC 9027) = 50 µM.
- Measure
- MIC
- Value
- 50 µM
- Target
- Pseudomonas aeruginosa
- Assay
- Not reported by source
AntimicrobialAnti-Gram-Positive observation
Record detail Table 4: Temporin-SHa MIC on H. pylori (ATCC 43504) = 3.12 µM.
- Measure
- MIC
- Value
- 3.12 µM
- Target
- Helicobacter pylori
- Assay
- Not reported by source
AntimicrobialAnti-Gram-Positive observation
Record detail Table 4: Temporin-SHa MIC on K. pneumoniae (DSM 26371) = 50 µM.
- Measure
- MIC
- Value
- 50 µM
- Target
- Klebsiella pneumoniae
- Assay
- Not reported by source
AntimicrobialAnti-Gram+Positive observation
Record detail Table 4: Temporin-SHa MIC on B. subtilis (ATCC 6633) = 1.56 µM.
- Measure
- MIC
- Value
- 1.56 µM
- Target
- Bacillus subtilis
- Assay
- Not reported by source
AntimicrobialAnti-Gram+Positive observation
Record detail Table 4: Temporin-SHa MIC on E. faecalis (DSM 2570) = 12.5 µM.
- Measure
- MIC
- Value
- 12.5 µM
- Target
- Enterococcus faecalis
- Assay
- Not reported by source
AntimicrobialAnti-Gram+Positive observation
Record detail Table 4: Temporin-SHa MIC on E. faecium (DSM 20477) = 6.25 µM.
- Measure
- MIC
- Value
- 6.25 µM
- Target
- Enterococcus faecium
- Assay
- Not reported by source
AntimicrobialAnti-Gram+Positive observation
Record detail Table 4: Temporin-SHa MIC on S. aureus (ATCC 6538) = 3.12 µM.
- Measure
- MIC
- Value
- 3.12 µM
- Target
- Staphylococcus aureus
- Assay
- Not reported by source
Anticancer 7 records
PMC9221442
7 observationsAnticancerCytotoxicPositive observation
Record detail Table 5: SHa IC50 on MCF-7 = 20.36 ± 5.64 µM.
- Measure
- other
- Value
- 20.36 µM
- Target
- MCF-7
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Table 5: SHa IC50 on HepG2 >100 µM.
- Measure
- other
- Value
- >100 µM
- Target
- HepG2
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Table 5: SHa IC50 on A549 >100 µM.
- Measure
- other
- Value
- >100 µM
- Target
- A549
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Table 5: SHa IC50 on A2780 >100 µM.
- Measure
- other
- Value
- >100 µM
- Target
- A2780
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Table 5: SHa IC50 on MiaPaCa >100 µM.
- Measure
- other
- Value
- >100 µM
- Target
- MiaPaCa
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Table 5: SHa IC50 on PC-3 >100 µM.
- Measure
- other
- Value
- >100 µM
- Target
- PC-3
- Assay
- Not reported by source
AnticancerCytotoxicNegative / threshold
Record detail Table 5: SHa IC50 on MNT-1 >100 µM.
- Measure
- other
- Value
- >100 µM
- Target
- MNT-1
- Assay
- Not reported by source
Toxicity 2 records
PMC9221442
2 observationsToxicityCytotoxicNegative / threshold
Record detail Table 5: SHa IC50 on IMR-90 >100 µM.
- Measure
- other
- Value
- >100 µM
- Target
- IMR-90
- Assay
- Not reported by source
ToxicityHemolyticPositive observation
Record detail Section 3.9: Temporin SHa estimated HC50 = 266.20 ± 41.27 µM.
- Measure
- HD50
- Value
- 266.2 µM
- Target
- Homo sapiens
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003524, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00