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PEPDIA-INT-005529

Gold

Temporin-SHa, Temporin-1Sa

Quality

Source DBs

Activities

Source refs

Literature

Patents

Integrated record

Sequence and molecular profile

FLSGIVGMLGKLF

Indexed sequence13 aa

1FLSGIVGMLGKLF

Length

Molecular weight

1381.75 Da

Formula

C67H108N14O15S

Structure type

Linear

Synthesis

Ribosomal

Chirality

Family

Gene

Residue composition

Physicochemical profile

Hydrophobic8

Membrane affinity proxy

Polar1

Solubility proxy

Charged1

Net charge proxy +1

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1381.7238 Da

Molecular formula

C67H108N14O15S

Theoretical pI

8.7501

Net charge at pH 7

0.7591

GRAVY

1.6692

Instability index

-23.4231

Aromaticity

0.1538

Topological polar surface area

458.77 Å²

cLogP

-0.6897

Hydrogen-bond donors

Hydrogen-bond acceptors

Rotatable bonds

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

FLSGIVGMLGKLF

HELM 2.0

validated simple linear

PEPTIDE1{F.L.S.G.I.V.G.M.L.G.K.L.F}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)CNC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(N)Cc1ccccc1)C(=O)NC(C(=O)NCC(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)C

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-005529,
  title = {Temporin-SHa, Temporin-1Sa},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-005529},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Temporin-SHa, Temporin-1Sa. (2026). PepDiana record PEPDIA-INT-005529. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-005529

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (66 records)

Stable record	Activity	Subtype	Value	Target	Assay method	Source
CTPDB_P005529_ACT_apd_0000	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	AP00898apd / linked
CTPDB_P005529_ACT_apd_0001	Antiviral	-	Not available in the current structured import	Unknown	Not reported by source	AP00898apd / linked
CTPDB_P005529_ACT_apd_0002	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	AP00898apd / linked
CTPDB_P005529_ACT_apd_0004	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	AP00898apd / linked
CTPDB_P005529_ACT_apd_0005	Toxicity	Hemolytic	Not available in the current structured import	Unknown	Not reported by source	AP00898apd / linked
CTPDB_P005529_ACT_apd_0006	Antimicrobial	Anti-Biofilm	Not available in the current structured import	Unknown	Not reported by source	AP00898apd / linked
CTPDB_P005529_ACT_camp_0007	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ1003camp / linked
CTPDB_P005529_ACT_camp_0008	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ1003camp / linked
CTPDB_P005529_ACT_camp_0009	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ1003camp / linked
CTPDB_P005529_ACT_camp_0010	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10085camp / linked
CTPDB_P005529_ACT_camp_0011	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	CAMPSQ10891camp / linked
CTPDB_P005529_ACT_dbaasp_0012	Antimicrobial	-	3 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0013	Antimicrobial	-	10-12 µM	Enterococcus faecalis ATCC 29212	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0014	Antimicrobial	-	2 µM	Bacillus megaterium	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0015	Antimicrobial	-	10 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0016	Antimicrobial	-	10 µM	Escherichia coli ATCC 35218	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0017	Antimicrobial	-	31 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0018	Antimicrobial	-	16 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0019	Antimicrobial	-	31 µM	Candida parapsilosis ATCC 22019	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0020	Antimicrobial	-	8 µM	Saccharomyces cerevisiae	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0021	Antimicrobial	-	18.1 µM	Leishmania infantum (promastigote)	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0022	Antimicrobial	-	22.8 µM	Leishmania infantum (amastigote)	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0023	Antimicrobial	-	10 µM	Escherichia coli ATCC 25922	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0024	Antimicrobial	-	12 µM	Escherichia coli ML-35p	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0025	Antimicrobial	-	50 µM	Pseudomonas aeruginosa ATCC 27853	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0026	Antimicrobial	-	25 µM	Salmonella enterica subsp. enterica serovar Enteritidis	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0027	Antimicrobial	-	6 µM	Acinetobacter baumannii ATCC 19606	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0028	Antimicrobial	-	12 µM	Klebsiella pneumoniae ATCC 13883	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0029	Antimicrobial	-	3 µM	Staphylococcus aureus ATCC 25923	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0030	Antimicrobial	-	6 µM	Staphylococcus aureus ST1065	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0031	Antimicrobial	-	6 µM	Staphylococcus aureus ATCC 43300	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0032	Antimicrobial	-	6 µM	Staphylococcus aureus ATCC BAA-44	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0033	Antimicrobial	-	6 µM	Streptococcus pyogenes ATCC 19615	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0034	Antimicrobial	-	6 µM	Listeria ivanovii	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0035	Antimicrobial	-	25 µM	Candida albicans ATCC 90028	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0036	Antimicrobial	-	100 µM	Candida parapsilosis ATCC 22019	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0037	Antimicrobial	-	12 µM	Saccharomyces cerevisiae	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0038	Antimicrobial	-	>60 µM	Human acute monocytic leukemia THP-1	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0039	Antimicrobial	-	560 µM	Human hepatocellular carcinoma HepG2	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0040	Antimicrobial	-	3.12 µM	Helicobacter pylori ATCC 43504	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0041	Antimicrobial	-	6.25 µM	Helicobacter pylori ATCC 43504	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0042	Antimicrobial	-	>50 µM	Helicobacter pylori ATCC 43504	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0043	Antimicrobial	-	12.5-25 µM	Helicobacter pylori	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0044	Antimicrobial	-	1558±324 µM	Human gastric carcinoma NCI-N87	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0045	Antimicrobial	-	<=1.56	Legionella feeleii ATCC 35072	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0046	Antimicrobial	-	<=1.56	Legionella longbeachae ATCC 33484	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0047	Antimicrobial	-	3.12 µM	Legionella pneumophila ATCC 33155	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0048	Antimicrobial	-	<=1.56	Legionella pneumophila Paris	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dbaasp_0049	Antimicrobial	-	10 µM	HSV-1	Not reported by source	DBAASPS_2204_chain0dbaasp / linked
CTPDB_P005529_ACT_dramp_0050	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	DRAMP01780dramp / linked
CTPDB_P005529_ACT_dramp_0051	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	DRAMP01780dramp / linked
CTPDB_P005529_ACT_dramp_0052	Antimicrobial	Anti-Gram+	Not available in the current structured import	Unknown	Not reported by source	DRAMP01780dramp / linked
CTPDB_P005529_ACT_dramp_0053	Antimicrobial	Anti-Gram-	Not available in the current structured import	Unknown	Not reported by source	DRAMP01780dramp / linked
CTPDB_P005529_ACT_dramp_0054	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	DRAMP01780dramp / linked
CTPDB_P005529_ACT_parapep_0055	Antiparasitic	Antiparasitic	20.0 µM	Unknown	MTT assay	1351parapep / linked
CTPDB_P005529_ACT_parapep_0056	Antiparasitic	Antiparasitic	20.0 µM	Unknown	MTT assay	1352parapep / linked
CTPDB_P005529_ACT_parapep_0057	Antiparasitic	Antiparasitic	Not available in the current structured import	Unknown	Alamar Blue assay	1748parapep / linked
CTPDB_P005529_ACT_parapep_0058	Antiparasitic	Antiparasitic	Not available in the current structured import	Unknown	Alamar Blue assay	1749parapep / linked
CTPDB_P005529_ACT_satpdb_0059	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb21516satpdb / linked
CTPDB_P005529_ACT_satpdb_0060	Antiparasitic	-	Not available in the current structured import	Unknown	Not reported by source	satpdb21516satpdb / linked
CTPDB_P005529_ACT_satpdb_0061	Toxicity	General Toxic	Not available in the current structured import	Unknown	Not reported by source	satpdb21516satpdb / linked
CTPDB_P005529_ACT_satpdb_0062	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb21516satpdb / linked
CTPDB_P005529_ACT_satpdb_0063	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb21516satpdb / linked
CTPDB_P005529_ACT_satpdb_0064	Antimicrobial	Antibacterial	Not available in the current structured import	Unknown	Not reported by source	satpdb26092satpdb / linked
CTPDB_P005529_ACT_satpdb_0065	Antimicrobial	-	Not available in the current structured import	Unknown	Not reported by source	satpdb26092satpdb / linked
CTPDB_P005529_ACT_satpdb_0066	Antimicrobial	Antifungal	Not available in the current structured import	Unknown	Not reported by source	satpdb26092satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

Records

Papers

Positive

Negative

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003524 View all experimental records

Provenance

Source database records (12)

apd

AP00898

Raw sequence

FLSGIVGMLGKLF

camp

CAMPSQ1003

Raw sequence

FLSGIVGMLGKLF

camp

CAMPSQ10085

Raw sequence

FLSGIVGMLGKLF

camp

CAMPSQ10891

Raw sequence

FLSGIVGMLGKLF

dbaasp

DBAASPS_2204_chain0

Raw sequence

FLSGIVGMLGKLF

dramp

DRAMP01780

Raw sequence

FLSGIVGMLGKLF

parapep

1351

Raw sequence

FLSGIVGMLGKLF

parapep

1352

Raw sequence

FLSGIVGMLGKLF

parapep

1748

Raw sequence

FLSGIVGMLGKLF

parapep

1749

Raw sequence

FLSGIVGMLGKLF

satpdb

satpdb21516

Raw sequence

FLSGIVGMLGKLF

satpdb

satpdb26092

Raw sequence

FLSGIVGMLGKLF

Citation trail

Literature (6 records)

Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica.

Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A2008

Peptides2008PMID 18584916

-

--PMID 31614561

-

--PMID 30813478

Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica.

Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A

Peptides2008PMID 32132569

Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica.

Abbassi F, Oury B, Blasco T, Sereno D, Bolbach G, Nicolas P, Hani K, Amiche M, Ladram A

Peptides2008PMID 30669255

-

--PMID 21805542

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:12.203743+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET

{
  "toxicity": [
    {
      "unit": "µM",
      "value": "25",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "value": "25",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Rat erythrocytes"
    },
    {
      "unit": "µM",
      "value": ">100",
      "source_db": "dbaasp",
      "assay_method": "50% Cell death",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human fibroblasts"
    },
    {
      "unit": "µM",
      "value": "20",
      "source_db": "dbaasp",
      "assay_method": "23% Cytotoxicity",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human Primary Epidermal Keratinocytes (HEK)"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.31614561]Display cytotoxic against human gastric cells(N87 cell:IC50=1558 ± 324μM)",
      "toxicity_type": "Cytotoxic"
    }
  ]
}

Source metadata

[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "parapep",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]

Structure metadata

{
  "source_db": "satpdb",
  "dssp_states": "CCTTTTTTTTTCC"
}