ProForma 2.0
Not calculated for this record
Back to Primary literature
Primary-literature peptidemedium evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003453
Ang II
Aliases: Ang II, Angiotensin II
Normalized sequence
DRVYIHPF
8 amino acids
Release PepDiana-V1-20260620
8
Activity records
2
Source papers
7
Positive
1
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Metabolic/Cardiovascular 4 records
PMC12296148
4 observationsMetabolic/CardiovascularOtherPositive observation
Record detail In the in vitro assay, the murine rAPA (mrAPA) showed a substantial cleavage of aspartate from Ang II (22,437 ± 3358 RFU, N = 12).
- Measure
- percent_inhibition
- Value
- 22,437 ± 3358 RFU
- Target
- Mus musculus
- Assay
- Not reported by source
Metabolic/CardiovascularOtherPositive observation
Record detail Recombinant APA accelerated the return of the SBP to pre-infusion levels elicited by ... Ang II (Figure 4 in the middle panel) (p = 0.0082).
- Measure
- survival_rate
- Value
- p = 0.0082
- Target
- Mus musculus
- Assay
- Not reported by source
Metabolic/CardiovascularOtherPositive observation
Record detail Compared to WT mice, Ang II caused an exaggerated increase in SBP in APAKO mice (Figure 5). p = 0.0196.
- Measure
- survival_rate
- Value
- p = 0.0196
- Target
- Mus musculus
- Assay
- Not reported by source
Metabolic/CardiovascularOtherPositive observation
Record detail The hypertensive effect of Ang II was quickly abolished by the administration of rACE2 (p = 0.02) (Figure 7). Over ten minutes p = 0.0248.
- Measure
- survival_rate
- Value
- p = 0.0248
- Target
- Mus musculus
- Assay
- Not reported by source
Other 4 records
PMC13118935
4 observationsOtherOtherPositive observation
Record detail The apparent permeability coefficient (Papp) of the loaded NLCs was 1.93 ± 0.11 (×10⁻⁵) cm/s
- Measure
- other
- Value
- 1.93 ± 0.11 (×10⁻⁵) cm/s (Papp)
- Target
- Sus scrofa
- Assay
- Not reported by source
OtherOtherPositive observation
Record detail steady-state flux (Jss) of 1.65 ± 0.09 (×10⁻²) µg/cm²·s
- Measure
- other
- Value
- 1.65 ± 0.09 (×10⁻²) µg/cm²·s (Jss)
- Target
- Sus scrofa
- Assay
- Not reported by source
OtherOtherPositive observation
Record detail Ang II-loaded NLCs (9.35 ± 1.36%) after 2 h
- Measure
- other
- Value
- 9.35 ± 1.36% (percent_permeation)
- Target
- Sus scrofa
- Assay
- Not reported by source
OtherOtherNegative / threshold
Record detail free Ang II solution remained below the quantification limit in the receptor compartment under the tested conditions
- Measure
- other
- Value
- below the quantification limit (percent_permeation)
- Target
- Sus scrofa
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003453, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00