International Journal of Molecular Sciences · 2025
Sequence evidence
DRVYIHPF
Ang II (1-8) is described as an octapeptide with N-terminal aspartate; sequence inferred from standard RAS nomenclature used in the paper.
Experimental observations
In the in vitro assay, the murine rAPA (mrAPA) showed a substantial cleavage of aspartate from Ang II (22,437 ± 3358 RFU, N = 12).
Recombinant APA accelerated the return of the SBP to pre-infusion levels elicited by ... Ang II (Figure 4 in the middle panel) (p = 0.0082).
Compared to WT mice, Ang II caused an exaggerated increase in SBP in APAKO mice (Figure 5). p = 0.0196.
The hypertensive effect of Ang II was quickly abolished by the administration of rACE2 (p = 0.02) (Figure 7). Over ten minutes p = 0.0248.
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.
