ProForma 2.0
validated simple linear
DRVYIHPF
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PEPDIA-INT-038027
GoldPepDiana tier derived from the internal quality score plus activity and literature coverage; it is not an external database rating.Angiotensin II
70
Quality PepDiana 0–100 composite of sequence, source, activity, literature, and cross-database evidence completeness.
3
Source DBs
4
Activities
3
Source refs
1
Literature
1
Patents
Integrated record
Sequence and molecular profile
DRVYIHPF
Indexed sequence8 aa
1DRVYIHPF
Length
8
Molecular weight
1046.20 Da
Formula
C50H71N13O12
Structure type
Linear
Synthesis
-
Chirality
-
Family
-
Gene
-
Residue composition
D
1
R
1
V
1
Y
1
I
1
H
1
P
1
F
1
Physicochemical profile
Hydrophobic4
Membrane affinity proxy
Polar0
Solubility proxy
Charged3
Net charge proxy +1
Aromatic3
Binding interaction proxy
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.
Computed properties
physchem-20260620Molecular weight
1046.1785 Da
Molecular formula
C50H71N13O12
Theoretical pI
6.7436
Net charge at pH 7
-0.1526
GRAVY
-0.325
Instability index
25.8
Aromaticity
0.25
Topological polar surface area
406.34 Ų
cLogP
-1.105
Hydrogen-bond donors
14
Hydrogen-bond acceptors
13
Rotatable bonds
29
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{D.R.V.Y.I.H.P.F}$$$$V2.0
Canonical SMILES
validated
CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(N)CC(=O)O)C(C)C)C(=O)NC(Cc1c[nH]cn1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O
Isomeric SMILES
validated
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Follow-up research
External analysis tools
Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.
Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.
Research workflow
Citation and local history
BibTeX
@misc{PEPDIA-INT-038027,
title = {Angiotensin II},
author = {{PepDiana Consortium}},
year = {2026},
howpublished = {PepDiana Multifunctional Peptide Database},
url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-038027},
note = {Accessed from local PepDiana development build}
}APA-style note
Angiotensin II. (2026). PepDiana record PEPDIA-INT-038027. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-038027
This record is saved to local recent-view history so it can reappear on the peptide browser page.
Integrated source-database annotations
Biological activity (4 records)
| Stable record | Activity | Subtype | Value | Target | Assay method | Source |
|---|---|---|---|---|---|---|
| CTPDB_P038027_ACT_dramp_0000 | Antimicrobial | - | Not available in the current structured import | Unknown | Not reported by source | DRAMP08721dramp / linked |
| CTPDB_P038027_ACT_dramp_0001 | Antimicrobial | Antibacterial | Not available in the current structured import | Unknown | Not reported by source | DRAMP08721dramp / linked |
| CTPDB_P038027_ACT_peptherdia_0002 | Clinical / Approved Drug | General Therapeutic | Not available in the current structured import | Unknown | Not reported by source | 81peptherdia / linked |
| CTPDB_P038027_ACT_satpdb_0003 | Bioregulatory | Cell-Cell Communication | Not available in the current structured import | Unknown | Not reported by source | satpdb11736satpdb / linked |
Sequence-linked cross-layer evidence
Linked primary-literature evidence
8
Records
2
Papers
7
Positive
1
Negative
1
Primary identities
These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.
Provenance
Source database records (3)
Citation trail
Literature (1 records)
[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB11842", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB11842)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209360s000lbl.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209360s000lbl.pdf)"}, {"text": "fda.gov", "url": "https://www.fda.gov/news-events/press-announcements/fda-approves-drug-treat-dangerously-low-blood-pressure", "markdown"
[{"text": "drugbank.com", "url": "https://go.drugbank.com/drugs/DB11842", "markdown": "[drugbank.com](https://go.drugbank.com/drugs/DB11842)"}, {"text": "fda.gov", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209360s000lbl.pdf", "markdown": "[fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209360s000lbl.pdf)"}, {"text": "fda.gov", "url": "https://www.fda.gov/news-events/press-announcements/fda-approves-drug-treat-dangerously-low-blood-pressure", "markdown"
--
IP evidence
Patents (1)
US 20080286210
dramp
Audit surface
Raw annotations and release metadata
Integrated record last updated: 2026-04-15T00:59:20.083593+00:00
Modification summary
No structured modification annotations are available for this record.
Source metadata
[
{
"source_db": "dramp",
"organism_name": "Unknown"
},
{
"source_db": "peptherdia",
"organism_name": "Unknown"
},
{
"source_db": "satpdb",
"organism_name": "Unknown"
}
]Structure metadata
{
"source_db": "satpdb",
"dssp_states": "CTTSCCCC"
}Clinical trials
[
{
"status": "Therapeutic",
"drug_name": "Angiotensin II",
"source_db": "peptherdia",
"indication": "Angiotensin II is a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock",
"approval_year": 2017,
"approval_agency": "FDA",
"administration_route": "IV"
}
]Approved drug annotations
{
"status": "Therapeutic",
"drug_name": "Angiotensin II",
"source_db": "peptherdia",
"indication": "Angiotensin II is a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock",
"approval_year": 2017,
"approval_agency": "FDA",
"administration_route": "IV"
}