ProForma 2.0
Not calculated for this record
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-003437
DCMAC-OT
Aliases: DCANBP-OT, DCMAC-OT, Me6I2-BODIPY-OT, oxytocin
Normalized sequence
CYIQNCPLG
9 amino acids
Release PepDiana-V1-20260620
20
Activity records
1
Source papers
12
Positive
8
Negative / threshold
Cross-layer links
Related Integrated records
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
Not calculated
Molecular formula
Not calculated
Theoretical pI
Not calculated
Net charge at pH 7
Not calculated
GRAVY
Not calculated
Instability index
Not calculated
Aromaticity
Not calculated
Topological polar surface area
Not calculated
cLogP
Not calculated
Hydrogen-bond donors
Not calculated
Hydrogen-bond acceptors
Not calculated
Rotatable bonds
Not calculated
Method: Not recorded
Tool: Not recorded
Calculated: Not recorded
Sequence representations
HELM 2.0
Not calculated for this record
Canonical SMILES
Not calculated for this record
Isomeric SMILES
Not calculated for this record
Paper-level observations
Experimental evidence grouped by activity
Other 13 records
PMC13206411
13 observationsOtherAnti-HIVPositive observation
Record detail Figure 5A; Table S2. OT positive control on hOTR.
- Measure
- EC50
- Value
- Not reported
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAnti-HIVNegative / threshold
Record detail Figure 5A; Table S2. DCMAC-OT 1 on hOTR. Text: '150 → >3900-fold higher EC50 values than parent peptides'.
- Measure
- EC50
- Value
- >3,900
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAnti-HIVNegative / threshold
Record detail Figure 5A; Table S2. DCANBP-OT 3 on hOTR. Text: '>2,100-3,900-fold higher EC50 values compared to parent peptides'.
- Measure
- EC50
- Value
- >2,100
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAnti-HIVPositive observation
Record detail Figure 5A; Table S2. Me6I2-BODIPY-OT 5 on hOTR. Text: '3- to 9-fold rightward shift in EC50 compared to OT'.
- Measure
- EC50
- Value
- =5
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAnti-HIVPositive observation
Record detail Figure 5D; Table S3. DCMAC-OT 1* on hOTR. Text: '75-fold increase in potency for hOTR'.
- Measure
- EC50
- Value
- =1
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAnti-HIVPositive observation
Record detail Figure 5D; Table S3. DCANBP-OT 3* on hOTR. Text: '400-fold increase in activity'.
- Measure
- EC50
- Value
- =3
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAnti-HIVPositive observation
Record detail Figure 5D; Table S3. Me6I2-BODIPY-OT 5* on hOTR. Text: 'only a minor increase in activity (~2-fold)'.
- Measure
- EC50
- Value
- ~2
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAntibacterialNegative / threshold
Record detail Figure 5F. DCMAC-OT 1 at 100 nM on hV1aR. Text: 'most caged photoprobes exhibited no activity at 100 nM'.
- Measure
- percent_inhibition
- Value
- na
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAntibacterialNegative / threshold
Record detail Figure 5F. DCMAC-OT 1 at 100 nM on hV1bR. Text: 'most caged photoprobes exhibited no activity at 100 nM'.
- Measure
- percent_inhibition
- Value
- na
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAntibacterialNegative / threshold
Record detail Figure 5F. DCANBP-OT 3 at 100 nM on hV1aR. Text: 'most caged photoprobes exhibited no activity at 100 nM'.
- Measure
- percent_inhibition
- Value
- na
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAntibacterialNegative / threshold
Record detail Figure 5F. DCANBP-OT 3 at 100 nM on hV1bR. Text: 'most caged photoprobes exhibited no activity at 100 nM'.
- Measure
- percent_inhibition
- Value
- na
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAntibacterialNegative / threshold
Record detail Figure 5F. Me6I2-BODIPY-OT 5 at 100 nM on hV1aR. Text: 'most caged photoprobes exhibited no activity at 100 nM'.
- Measure
- percent_inhibition
- Value
- na
- Target
- Homo sapiens
- Assay
- Not reported by source
OtherAntibacterialNegative / threshold
Record detail Figure 5F. Me6I2-BODIPY-OT 5 at 100 nM on hV1bR. Text: 'most caged photoprobes exhibited no activity at 100 nM'.
- Measure
- percent_inhibition
- Value
- na
- Target
- Homo sapiens
- Assay
- Not reported by source
Toxicity 7 records
PMC13206411
7 observationsToxicityCytotoxicPositive observation
Record detail Figure 4. OT positive control in MTT assay. Text: 'OT itself reduced cell viability over 48 h'.
- Measure
- cell_viability
- Value
- =4%
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityCytotoxicPositive observation
Record detail Figure 4. DCMAC-OT 1 in MTT assay. Text: 'Most photocaged OT probes ... exhibited higher cell viability than unmodified OT'.
- Measure
- cell_viability
- Value
- =4%
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityCytotoxicPositive observation
Record detail Figure 4. DCMAC-OT 1* in MTT assay. Text: 'The uncaged compound mixtures exhibited values comparable to those of OT'.
- Measure
- cell_viability
- Value
- =4%
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityCytotoxicPositive observation
Record detail Figure 4. DCANBP-OT 3 in MTT assay. Text: 'Most photocaged OT probes ... exhibited higher cell viability than unmodified OT'.
- Measure
- cell_viability
- Value
- =4%
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityCytotoxicPositive observation
Record detail Figure 4. DCANBP-OT 3* in MTT assay. Text: 'The uncaged compound mixtures exhibited values comparable to those of OT'.
- Measure
- cell_viability
- Value
- =4%
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityCytotoxicPositive observation
Record detail Figure 4. Me6I2-BODIPY-OT 5 in MTT assay. Text: 'except for 1 uM 5' exhibited higher cell viability than unmodified OT.
- Measure
- cell_viability
- Value
- =4%
- Target
- Homo sapiens
- Assay
- Not reported by source
ToxicityCytotoxicPositive observation
Record detail Figure 4. Me6I2-BODIPY-OT 5* in MTT assay. Text: 'The uncaged compound mixtures exhibited values comparable to those of OT'.
- Measure
- cell_viability
- Value
- =4%
- Target
- Homo sapiens
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-003437, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00