PEPDIA-PLP-001507

Table 3: BP145 MIC 50 µg/ml against S. aureus ATCC 29213

Table 3: BP145 MBC 50 µg/ml against S. aureus ATCC 29213

Table 3: BP145 MIC 50 µg/ml against S. aureus MRSA USA 300

Table 3: BP145 MBC 50 µg/ml against S. aureus MRSA USA 300

Table 3: BP145 MIC 50 µg/ml against P. aeruginosa ATCC 27853

Table 3: BP145 MBC 50 µg/ml against P. aeruginosa ATCC 27853

Table 3: BP145 MIC 50 µg/ml against P. aeruginosa ST175-1

Table 3: BP145 MBC 50 µg/ml against P. aeruginosa ST175-1

Table 3: BP145 MIC 6.25 µg/ml against A. baumannii ATCC 19606

Table 3: BP145 MBC 12.5 µg/ml against A. baumannii ATCC 19606

Table 3: BP145 MIC 25 µg/ml against A. baumannii IB010

Table 3: BP145 MBC 25 µg/ml against A. baumannii IB010

Table 3: BP145 MIC 12.5 µg/ml against A. baumannii Ab-1

Table 3: BP145 MBC 12.5 µg/ml against A. baumannii Ab-1

Table 3: BP145 MIC 25 µg/ml against K. pneumoniae ATCC 43816

Table 3: BP145 MBC 25 µg/ml against K. pneumoniae ATCC 43816

Table 3: BP145 MIC 12.5 µg/ml against K. pneumoniae CG258

Table 3: BP145 MBC 12.5 µg/ml against K. pneumoniae CG258

Table 3: BP145 MIC 6.25 µg/ml against E. coli ATCC 25922

Table 3: BP145 MBC 6.25 µg/ml against E. coli ATCC 25922

Table 3: BP145 MIC 12.5 µg/ml against E. coli ESBL 1057.1

Table 3: BP145 MBC 12.5 µg/ml against E. coli ESBL 1057.1

Section 3.4: BP145 reduced SBF indices compared to BP607 for K. pneumoniae ATCC 43816 (Fig. 3)

Section 3.4: BP145 inhibited biofilm formation of K. pneumoniae CG258 (Fig. 3)

Section 3.3: BP145 was bactericidal at 2x MIC after 24h against K. pneumoniae CG258

Section 3.3: all three peptides were bactericidal for E. coli ESBL 1057.1 at 6 and 24h at MIC

Section 3.3: BP145 displayed bactericidal activity at 6h but not at 24h against K. pneumoniae CG258 at MIC

Section 3.3: none of the peptides were bactericidal for A. baumannii ATCC 19606 at 6h or 24h at MIC

Section 3.1: BP145 inhibited growth of all strains by ≈90% at 50 µg/ml

Section 3.1: BP146 reduced at least 89% growth in all strains except for P. aeruginosa ST175-1

Section 3.1: BP143 had ≥83% growth inhibition for all Gram-negative strains tested

Section 3.5: BP145 showed 35% peptide remaining after 60 min in human serum

Table 2: S. aureus (KCTC 1621) MIC = 4 μM for BP100.

Table 2: S. epidermidis (KCTC 1917) MIC = 4 μM for BP100.

Table 2: B. subtilis (KCTC 3068) MIC = 8 μM for BP100.

Table 2: MRSA (CCARM 3089) MIC = 32 μM for BP100.

Table 2: MRSA (CCARM 3090) MIC = 64 μM for BP100.

Table 2: E. coli (KCTC 1682) MIC = 4 μM for BP100.

Table 2: P. aeruginosa (KCTC 1637) MIC = 16 μM for BP100.

Table 2: S. typhimurium (KCTC 1926) MIC = 4 μM for BP100.

Table 2: MDRPA (CCARM 2095) MIC = 32 μM for BP100.

Table 2: MDRPA (CCARM 2109) MIC = 16 μM for BP100.

Table 3: BP100 MBIC50 = 4–8 μM against MDRPA.

Table 3: BP100 MBIC90 = 8 μM against MDRPA.

Table 3: BP100 MBEC50 = 16–32 μM against MDRPA.

Table 3: BP100 MBEC90 = 32 μM against MDRPA.

Table 4: E. coli control MIC = 4 μM for BP100.

Table 4: E. coli MIC = 16 μM for BP100 in 150 mM NaCl.

Table 4: E. coli MIC = 16 μM for BP100 in 4.5 mM KCl.

Table 4: E. coli MIC = 16 μM for BP100 in 6 μM NH4Cl.

Table 4: E. coli MIC = 16 μM for BP100 in 1 mM MgCl2.

Table 4: E. coli MIC = 16 μM for BP100 in 2.5 mM CaCl2.

Table 4: E. coli MIC = 16 μM for BP100 in 4 μM FeCl3.

Table 4: E. coli MIC = 16 μM for BP100 in 10% human serum.

Table 4: S. aureus control MIC = 4 μM for BP100.

Table 4: S. aureus MIC = 16 μM for BP100 in 150 mM NaCl.

Table 4: S. aureus MIC = 16 μM for BP100 in 4.5 mM KCl.

Table 4: S. aureus MIC = 16 μM for BP100 in 6 μM NH4Cl.

Table 4: S. aureus MIC = 16 μM for BP100 in 1 mM MgCl2.

Table 4: S. aureus MIC = 16 μM for BP100 in 2.5 mM CaCl2.

Table 4: S. aureus MIC = 16 μM for BP100 in 4 μM FeCl3.

Table 4: S. aureus MIC = 32 μM for BP100 in 10% human serum.

Table 1: BP100 MIC against Ea 2.5 - 5.0 μM

Table 1: BP100 MIC against Pss 2.5 - 5.0 μM

Table 1: BP100 MIC against Xav 5.0 - 10 μM

Table 1: BP100 MIC against Dc 5-10 μM

Table 1: BP100 MIC against Fv <2.5 μM

Table 1: BP145 hemolysis 27±0.7% at 150 µM

Table 1: BP142 hemolysis 0±0.5% at 150 µM

Table 1: BP143 hemolysis 2±2.0% at 150 µM

Table 1: BP144 hemolysis 2±2.0% at 150 µM

Table 1: BP146 hemolysis 23±2.0% at 150 µM

Table 1: BP157 hemolysis 0±0.7% at 150 µM

Table 1: BP164 hemolysis 0±0.5% at 150 µM

Table 1: BP165 hemolysis 1±0.5% at 150 µM

Table 1: BP166 hemolysis 0±0% at 150 µM

Table 1: BP168 hemolysis 1±1.2% at 150 µM

Section 3.6: BP145 presented less toxicity than colistin with 70% survival after 24h (Fig. 5B)

Table 1: BP100 phytotoxicity (germination) 64 μM

Table 1: BP100 phytotoxicity (inoculation) 0.90 ± 0.05 cm

Table 1: BP100 hemolytic activity 22.0 ± 2.8%

Table 2: HC10 >256 μM for BP100 (no detectable hemolysis at 256 μM).