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Paper-scoped peptide mentionSequence reported

BP145

PMC11904594::PEP000010

Source publication

Identification and characterization of amphipathic antimicrobial peptides with broad spectrum activity against multi-drug resistant bacteria.

Current Research in Microbial Sciences · 2025

DOI 10.1016/j.crmicr.2025.100363 PMC11904594 PMID 40084383

Sequence status: reported
Standardization: Sequence ready
Source location: table
Activity records: 32

Sequence evidence

Reported molecular identity

KKLFKKILKYLNH

Table 1: BP145, KkLFKKILKYL-NH2

Resolved peptide links

PEPDIA-PLP-001507

Experimental observations

Records linked to this mention

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 50 µg/ml against S. aureus ATCC 29213

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 50 µg/mL
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 50 µg/ml against S. aureus ATCC 29213

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 50 µg/mL
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 50 µg/ml against S. aureus MRSA USA 300

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 50 µg/mL
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 50 µg/ml against S. aureus MRSA USA 300

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 50 µg/mL
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 50 µg/ml against P. aeruginosa ATCC 27853

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 50 µg/mL
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 50 µg/ml against P. aeruginosa ATCC 27853

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 50 µg/mL
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 50 µg/ml against P. aeruginosa ST175-1

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 50 µg/mL
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 50 µg/ml against P. aeruginosa ST175-1

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 50 µg/mL
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 6.25 µg/ml against A. baumannii ATCC 19606

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 6.25 µg/mL
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 12.5 µg/ml against A. baumannii ATCC 19606

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 12.5 µg/mL
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 25 µg/ml against A. baumannii IB010

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 25 µg/mL
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 25 µg/ml against A. baumannii IB010

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 25 µg/mL
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 12.5 µg/ml against A. baumannii Ab-1

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 12.5 µg/mL
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 12.5 µg/ml against A. baumannii Ab-1

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 12.5 µg/mL
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 25 µg/ml against K. pneumoniae ATCC 43816

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 25 µg/mL
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 25 µg/ml against K. pneumoniae ATCC 43816

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 25 µg/mL
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 12.5 µg/ml against K. pneumoniae CG258

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 12.5 µg/mL
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 12.5 µg/ml against K. pneumoniae CG258

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 12.5 µg/mL
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 6.25 µg/ml against E. coli ATCC 25922

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 6.25 µg/mL
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 6.25 µg/ml against E. coli ATCC 25922

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 6.25 µg/mL
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MIC 12.5 µg/ml against E. coli ESBL 1057.1

Mention PMC11904594::PEP000010PMC11904594table

Measure: MIC
Value: 12.5 µg/mL
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: BP145 MBC 12.5 µg/ml against E. coli ESBL 1057.1

Mention PMC11904594::PEP000010PMC11904594table

Measure: MBC
Value: 12.5 µg/mL
Target: Escherichia coli
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Table 1: BP145 hemolysis 27±0.7% at 150 µM

Mention PMC11904594::PEP000010PMC11904594table

Measure: hemolysis
Value: 27±0.7%
Target: Not reported by source
Assay: Not reported by source

Source publication

ToxicityGeneral ToxicPositive observation

Section 3.6: BP145 presented less toxicity than colistin with 70% survival after 24h (Fig. 5B)

Mention PMC11904594::PEP000010PMC11904594text

Measure: survival_rate
Value: 70% survival after 24h
Target: Galleria mellonella
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Section 3.4: BP145 reduced SBF indices compared to BP607 for K. pneumoniae ATCC 43816 (Fig. 3)

Mention PMC11904594::PEP000010PMC11904594text

Measure: biofilm_inhibition
Value: weak to moderate biofilm producer; reduced SBF indices compared to BP607
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Section 3.4: BP145 inhibited biofilm formation of K. pneumoniae CG258 (Fig. 3)

Mention PMC11904594::PEP000010PMC11904594text

Measure: biofilm_inhibition
Value: weak to moderate biofilm producer; inhibited biofilm formation
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Section 3.3: BP145 was bactericidal at 2x MIC after 24h against K. pneumoniae CG258

Mention PMC11904594::PEP000010PMC11904594text

Measure: time_kill
Value: bactericidal at 2x MIC at 24h
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Section 3.3: all three peptides were bactericidal for E. coli ESBL 1057.1 at 6 and 24h at MIC

Mention PMC11904594::PEP000010PMC11904594text

Measure: time_kill
Value: bactericidal at MIC at 6h and 24h
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Section 3.3: BP145 displayed bactericidal activity at 6h but not at 24h against K. pneumoniae CG258 at MIC

Mention PMC11904594::PEP000010PMC11904594text

Measure: time_kill
Value: bactericidal at MIC at 6h, not at 24h
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Section 3.3: none of the peptides were bactericidal for A. baumannii ATCC 19606 at 6h or 24h at MIC

Mention PMC11904594::PEP000010PMC11904594text

Measure: time_kill
Value: not bactericidal at MIC at 6h or 24h
Target: Acinetobacter baumannii
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Section 3.1: BP145 inhibited growth of all strains by ≈90% at 50 µg/ml

Mention PMC11904594::PEP000010PMC11904594text

Measure: percent_inhibition
Value: ≈90%
Target: multiple
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Section 3.5: BP145 showed 35% peptide remaining after 60 min in human serum

Mention PMC11904594::PEP000010PMC11904594text

Measure: percent_inhibition
Value: 35% remaining after 60 min
Target: Not reported by source
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.