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Primary-literature peptidemedium evidence

PEPDIA-PLP-001033

CAP-18_31

Aliases: CAP-18_31, D-CAP-18_31

Normalized sequence

GLRKRLRKFRNKIKEKLKKIGQKIQGLLPKL

31 amino acids

Release PepDiana-V1-20260620

44

Activity records

1

Source papers

44

Positive

0

Negative / threshold

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

3729.6451 Da

Molecular formula

C171H311N55O37

Theoretical pI

12

Net charge at pH 7

11.7539

GRAVY

-0.9935

Instability index

31.2806

Aromaticity

0.0323

Topological polar surface area

1575.88 Å²

cLogP

-10.5144

Hydrogen-bond donors

56

Hydrogen-bond acceptors

49

Rotatable bonds

143

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620

ProForma 2.0

validated simple linear

GLRKRLRKFRNKIKEKLKKIGQKIQGLLPKL

HELM 2.0

validated simple linear

PEPTIDE1{G.L.R.K.R.L.R.K.F.R.N.K.I.K.E.K.L.K.K.I.G.Q.K.I.Q.G.L.L.P.K.L}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)CN)C(C)CC)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)O)C(C)CC

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC

Paper-level observations

Experimental evidence grouped by activity

Antimicrobial 38 records

PMC12382740

38 observations

AntimicrobialAntibacterialPositive observation

Table 2: CAP-18_31 MIC 8 mg/L against P. aeruginosa strain 121007

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 8 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: CAP-18_31 MIC 0.5 mg/L against P. aeruginosa ATCC 121110

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: D-CAP-18_31 MIC 2 mg/L against P. aeruginosa strain 121007

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 2 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: D-CAP-18_31 MIC 0.25 mg/L against P. aeruginosa ATCC 121110

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 0.25 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: CAP-18_31 MIC50 2 mg/L against P. aeruginosa strain panel

Mention PMC12382740::PEP000002PMC12382740table

Measure: other
Value: 2 (MIC_50)
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: CAP-18_31 MIC90 16 mg/L against P. aeruginosa strain panel

Mention PMC12382740::PEP000002PMC12382740table

Measure: other
Value: 16 (MIC_90)
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: D-CAP-18_31 MIC50 4 mg/L against P. aeruginosa strain panel

Mention PMC12382740::PEP000009PMC12382740table

Measure: other
Value: 4 (MIC_50)
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: D-CAP-18_31 MIC90 16 mg/L against P. aeruginosa strain panel

Mention PMC12382740::PEP000009PMC12382740table

Measure: other
Value: 16 (MIC_90)
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 12-1110 S1

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 0.25 mg/L against P. aeruginosa 12-1110 S1

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 0.25 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 21-0505 S2

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 21-0505 S2

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 8 mg/L against P. aeruginosa 21-0308 R2

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 8 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 4 mg/L against P. aeruginosa 21-0308 R2

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 2 mg/L against P. aeruginosa 15-0803 S3

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 2 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 4 mg/L against P. aeruginosa 15-0803 S3

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 15-0307 S4

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 15-0307 S4

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 1 mg/L against P. aeruginosa 21-0410 S5

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 1 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 21-0410 S5

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 8 mg/L against P. aeruginosa 16359347-2 R3

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 8 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 4 mg/L against P. aeruginosa 16359347-2 R3

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 1 mg/L against P. aeruginosa 36a

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 1 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 2 mg/L against P. aeruginosa 36a

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 2 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 4 mg/L against P. aeruginosa 38a

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 4 mg/L against P. aeruginosa 38a

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 4 mg/L against P. aeruginosa 27853

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 4 mg/L against P. aeruginosa 27853

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 16 mg/L against P. aeruginosa C1

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 16 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 16 mg/L against P. aeruginosa C1

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 16 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 16 mg/L against P. aeruginosa C2

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 16 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 16 mg/L against P. aeruginosa C2

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 16 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 2 mg/L against P. aeruginosa C3

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 2 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 8 mg/L against P. aeruginosa C3

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 8 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 4 mg/L against P. aeruginosa C4

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 8 mg/L against P. aeruginosa C4

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 8 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 2 mg/L against P. aeruginosa C5

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 2 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: D-CAP-18_31 MIC 4 mg/L against P. aeruginosa C5

Mention PMC12382740::PEP000009PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

Toxicity 6 records

PMC12382740

6 observations

ToxicityHemolyticPositive observation

Table 4: CAP-18_31 hemolysis IC50 185.26 uM against human erythrocytes

Mention PMC12382740::PEP000002PMC12382740table

Measure: other
Value: 185.26 µM
Target: Homo sapiens
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Table 4: D-CAP-18_31 hemolysis IC50 108.44 uM against human erythrocytes

Mention PMC12382740::PEP000009PMC12382740table

Measure: other
Value: 108.44 µM
Target: Homo sapiens
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Table 4: CAP-18_31 cytotoxicity IC50 1.31 uM against A549 cells

Mention PMC12382740::PEP000002PMC12382740table

Measure: other
Value: 1.31 µM
Target: A549
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Table 4: D-CAP-18_31 cytotoxicity IC50 12.32 uM against A549 cells

Mention PMC12382740::PEP000009PMC12382740table

Measure: other
Value: 12.32 µM
Target: A549
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Section 2.2: CAP-18_31 IC50 13.1 uM against HeLa cells

Mention PMC12382740::PEP000002PMC12382740text

Measure: other
Value: 13.1 µM
Target: HeLa
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Section 3: D-CAP-18_31 IC50 6.16 uM against HeLa cells (mentioned in discussion)

Mention PMC12382740::PEP000009PMC12382740text

Measure: other
Value: 6.16 µM
Target: HeLa
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-001033, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00