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Paper-scoped peptide mentionSequence reported

CAP-18_31

PMC12382740::PEP000002

Source publication

In Vitro and In Vivo Characterization of Novel Cathelicidin-Based Peptides with Antimicrobial Activity Against Pseudomonas aeruginosa

Antibiotics · 2025

DOI 10.3390/antibiotics14080838 PMC12382740 PMID 40868032

Sequence status: reported
Standardization: Sequence ready
Source location: table
Activity records: 22

Sequence evidence

Reported molecular identity

GLRKRLRKFRNKIKEKLKKIGQKIQGLLPKL

Table 2: CAP-18_31 sequence GLRKRLRKFRNKIKEKLKKIGQKIQGLLPKL

Resolved peptide links

PEPDIA-PLP-001033

Experimental observations

Records linked to this mention

AntimicrobialAntibacterialPositive observation

Table 2: CAP-18_31 MIC 8 mg/L against P. aeruginosa strain 121007

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 8 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: CAP-18_31 MIC 0.5 mg/L against P. aeruginosa ATCC 121110

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: CAP-18_31 MIC50 2 mg/L against P. aeruginosa strain panel

Mention PMC12382740::PEP000002PMC12382740table

Measure: other
Value: 2 (MIC_50)
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 3: CAP-18_31 MIC90 16 mg/L against P. aeruginosa strain panel

Mention PMC12382740::PEP000002PMC12382740table

Measure: other
Value: 16 (MIC_90)
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Table 4: CAP-18_31 hemolysis IC50 185.26 uM against human erythrocytes

Mention PMC12382740::PEP000002PMC12382740table

Measure: other
Value: 185.26 µM
Target: Homo sapiens
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Table 4: CAP-18_31 cytotoxicity IC50 1.31 uM against A549 cells

Mention PMC12382740::PEP000002PMC12382740table

Measure: other
Value: 1.31 µM
Target: A549
Assay: Not reported by source

Source publication

ToxicityCytotoxicPositive observation

Section 2.2: CAP-18_31 IC50 13.1 uM against HeLa cells

Mention PMC12382740::PEP000002PMC12382740text

Measure: other
Value: 13.1 µM
Target: HeLa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 12-1110 S1

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 21-0505 S2

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 8 mg/L against P. aeruginosa 21-0308 R2

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 8 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 2 mg/L against P. aeruginosa 15-0803 S3

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 2 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 0.5 mg/L against P. aeruginosa 15-0307 S4

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 0.5 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 1 mg/L against P. aeruginosa 21-0410 S5

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 1 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 8 mg/L against P. aeruginosa 16359347-2 R3

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 8 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 1 mg/L against P. aeruginosa 36a

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 1 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 4 mg/L against P. aeruginosa 38a

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 4 mg/L against P. aeruginosa 27853

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 16 mg/L against P. aeruginosa C1

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 16 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 16 mg/L against P. aeruginosa C2

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 16 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 2 mg/L against P. aeruginosa C3

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 2 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 4 mg/L against P. aeruginosa C4

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 4 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table A1: CAP-18_31 MIC 2 mg/L against P. aeruginosa C5

Mention PMC12382740::PEP000002PMC12382740table

Measure: MIC
Value: 2 other
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.