Experimental evidence search

RV-23 was not cytotoxic up to the highest dose (50 μM). Figure 1 shows cell viability at 50–3.125 μM.

RV-23 was found to be more active than AR-23, with an inhibitory concentration of 50% (IC50) at 10 μM ... in co-treatment.

RV-23 ... IC50 at ... 6.25 μM ... in virus pre-treatment assays.

On the contrary, no activity was observed after the viral adsorption step (post-treatment), indicating that the peptides did not interfere later in the infection.

Hylin-a1 and RV-23 have lower toxicity with a 50% cytotoxic concentration (CC50) of 100 μM.

Table 1: RV-23 MIC 6.25 μM against K. pneumoniae ATCC 10031.

Table 1: RV-23 MBC 12.5 μM against K. pneumoniae ATCC 10031.

Table 1: RV-23 MIC 12.5 μM against E. coli ATCC 25992.

Table 1: RV-23 MBC 12.5 μM against E. coli ATCC 25992.

Table 2: RV-23 MIC 12.5 μM against K. pneumoniae 1711.

Table 2: RV-23 MBC 12.5 μM against K. pneumoniae 1711.

Table 2: RV-23 MIC 50 μM against K. pneumoniae 311.

Table 2: RV-23 MBC 50 μM against K. pneumoniae 311.

Table 2: RV-23 MIC 12.5 μM against K. pneumoniae 1745.

Table 2: RV-23 MBC 25 μM against K. pneumoniae 1745.

Table 2: RV-23 MIC 12.5 μM against K. pneumoniae 1746.

Table 2: RV-23 MBC N/D against K. pneumoniae 1746.

Table 2: RV-23 MIC 12.5 μM against E. coli 2267.

Table 2: RV-23 MBC 12.5 μM against E. coli 2267.

Table 2: RV-23 MIC 25 μM against E. coli 3140.